Human metapneumovirus in Southern Brazil

Gregianini, Tatiana Schäffer; Seadi, Claudete Farina; Menegolla, Ivone Andreatta; Martins, Letícia Garay; Ikuta, Nilo; Wolf, Jonas Michel; Lunge, Vagner Ricardo

doi:10.1590/0037-8682-0435-2017

Cited by 13 publications

(21 citation statements)

References 39 publications

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“…Viral dynamics in the human population is related to host, viral and environmental determinants, whose complexity is not well understood, especially when different viruses are involved in a pathological condition. Accordingly, respiratory infections in RS can be caused by a plethora of pathogens, including IAV, IBV, hPIV, hRSV, hAdV, and metapneumovirus; in this sense, our findings show that hPIV activity is high during fall and spring, just before and after influenza and hRSV season, which occur in winter (from May to August) . Similarly, a study analyzed the circulation of hPIV, hRSV, and IAV in Fortaleza (Northeast Brazil) and found an inverse association between hPIV, hRSV, and IAV circulation .…”

Section: Discussionsupporting

confidence: 50%

A 28‐year study of human parainfluenza in Rio Grande do Sul, Southern Brazil

Gregianini

Seadi

Neto

et al. 2019

Journal of Medical Virology

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Problem: Human parainfluenza virus (hPIV) is an important pathogen in respiratory infections, however the health burden of hPIV is underestimated. This study describes the infections by hPIV1-3 in Rio Grande do Sul, Brazil, from 1990 to 2017, providing data of the frequency and seasonality of cases and associated clinical symptoms. Method of study: Nasopharyngeal samples of patients with respiratory infectionwere collected, clinical data were analyzed, and immunofluorescence was used to detect hPIV.Results: Respiratory viruses were detected in 33.63% of respiratory infections. In a total of 11 606 cases of viral respiratory infection, 781 were positive for hPIV; hPIV prevalence ranged from 2.14% to 27% of viral respiratory infections. hPIV1 circulates mainly during fall; hPIV3 circulation, in turn, starts in fall and peaks during spring; and cases of hPIV2 are reported along the year, with peaks in fall and early spring. The most affected age group was children, with hPIV prevalence of 74.23% in patients for less than 1 year. A higher proportion of girls were infected than boys, however, no difference by sex was observed considering all age groups. The most frequent type was hPIV3, especially in hospitalized patients. Both hPIV1 and 3 were associated with dyspnea, while hPIV2 caused mild symptoms mainly in nonhospitalized patients.Nineteen fatalities occurred, 89.5% of them associated with risk factors (prematurity; chronic diseases; age, <1 or >60 years). Conclusion: hPIV causes a high number of respiratory infections, leading to hospitalization especially in children; epidemiological and surveillance studies are important for the control and management of respiratory infections. K E Y W O R D S acute respiratory infection, hPIV infection, respiratory virus, severe acute respiratory infection

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Section: Discussionsupporting

confidence: 50%

A 28‐year study of human parainfluenza in Rio Grande do Sul, Southern Brazil

Gregianini

Seadi

Neto

et al. 2019

Journal of Medical Virology

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“…There are studies that describe the main symptoms in positive cases: cough, fever, dyspnea, sore throat, hoarseness of voice, rhinorrhea, myalgia, anorexia, vomiting, irritability, pharyngitis, otitis media, conjunctivitis, diarrhea and lethargy. These results align with the findings of this study [16,17,26].…”

Section: Discussionsupporting

confidence: 93%

“…Females were the most affected, according to one study; the female gender is a risk factor for developing a severe disease due to HMPV [16]. Studies show that the highest prevalence of HMPV occurs in females [17].…”

Section: Discussionmentioning

confidence: 99%

Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza

et al. 2020

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Human metapneumovirus (HMPV) is one of the four major viral pathogens associated with acute respiratory tract infections (ARI) and creates a substantial burden of disease, particularly in young children (<5 years) and older individuals (≥65 years). The objective of this study was to determine the epidemiological behavior of HMPV in Mexico. This retrospective study was conducted over a nine-year period and used 7283 influenza-negative respiratory samples from hospitalized and deceased patients who presented Severe Acute Respiratory Infection (SARI). The samples were processed with the help of qualitative multiplex RT-PCR for simultaneous detection of 14 respiratory viruses (xTAG ® RVP FAST v2). 40.8% of the samples were positive for respiratory viruses, mainly rhinovirus/enterovirus (47.6%), respiratory syncytial virus (15.9%), HMPV (11.1%) and parainfluenza virus (8.9%). Other respiratory viruses and co-infections accounted for 16.5%. HMPV infects all age groups, but the most affected group was infants between 29 days and 9 years of age (65.6%) and adults who are 40 years and older (25.7%). HMPV circulates every year from November to April, and the highest circulation was observed in late winter. The results of this study aim to raise awareness among clinicians about the high epidemiological impact of HMPV in young children and older individuals in order to reduce the economic burden in terms of health care costs.

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“…The first may be explained by widely documented local variation in annual hMPV circulation, 29 exacerbated here by limited sampling during the expected hMPV season, usually late winter/early spring as reported previously in São Paulo. 30 The absence of FLU seasonality, usually related to rainy seasons in tropical and subtropical regions, 31 may have been facilitated by the population characteristics of the Brazilian slum allowing continued FLU transmission and maintenance over relatively dryer seasons.…”

Section: Resultsmentioning

confidence: 80%

Typical epidemiology of respiratory virus infections in a Brazilian slum

Góes

Zerbinati

Tateno

et al. 2019

Journal of Medical Virology

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Host population size, density, immune status, age structure, and contact rates are critical elements of virus epidemiology. Slum populations stand out from other settings and may present differences in the epidemiology of acute viral infections. We collected nasopharyngeal specimens from 282 children aged ≤5 years with acute respiratory tract infection (ARI) during 2005 to 2006 in one of the largest Brazilian slums. We conducted real-time reverse transcription-polymerase chain reaction (RT-PCR) for 16 respiratory viruses, nested RT-PCR-based typing of rhinoviruses (HRVs), and collected clinical symptoms. Viruses were common causes of respiratory disease;with ≥1 virus being detected in 65.2% of patients. We detected 15 different viruses during 1 year with a predominance of HRV (33.0%) and human respiratory syncytial virus (hRSV, 12.1%) infections, and a high rate of viral coinfections (28.3%). We observed seasonality of hRSV, HRV and human coronavirus infections, more severe symptoms in hRSV and influenza virus (FLU) infections and prolonged circulation of seven HRV clusters likely representing distinct serotypes according to genomic sequence distances. Potentially unusual findings included the absence of human metapneumovirus detections and lack of typical FLU seasonal patterns, which may be linked to the population size and density of the slum. Nonetheless, most epidemiological patterns were similar to other studies globally, suggesting surprising similarities of virus-associated ARI across highly diverse settings and a complex impact of population characteristics on respiratory virus epidemiology. K E Y W O R D S acute respiratory infection, Brazil, epidemiology, real-time polymerase chain reaction, respiratory tract infections, slum, viruses ---

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Human metapneumovirus in Southern Brazil

Abstract: These findings indicate that hMPV is in circulation in southern Brazil and highlight the importance of diagnosing hMPV for influenza-like illness in the population.

Cited by 13 publications

References 39 publications

A 28‐year study of human parainfluenza in Rio Grande do Sul, Southern Brazil

A 28‐year study of human parainfluenza in Rio Grande do Sul, Southern Brazil

Human Metapneumovirus: Etiological Agent of Severe Acute Respiratory Infections in Hospitalized and Deceased Patients with a Negative Diagnosis of Influenza

Typical epidemiology of respiratory virus infections in a Brazilian slum

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