25(OH) vitamin D deficiency in lymphoid malignancies, its prevalence and significance. Are we fully aware of it?

Djurasinovic, Vladislava; Mihaljević, Biljana; Grujičić, Sandra B Šipetić; Ignjatović, Svetlana; Trajković, Goran; Todorović-Balint, Milena; Bila, Jelena; Andjelic, Bosko; Jelicic, Jelena; Vuković, V.; Nikolić, Aleksandra; Kłęk, Stanisław

doi:10.1007/s00520-018-4101-9

Cited by 10 publications

(15 citation statements)

References 30 publications

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“…Vitamin D de ciency is also common in lymphoma patients. Previous studies have shown that when the threshold was set at 50 nmol/L, the vitamin D de ciency rate ranged from 67%-88% [11,23], which mainly among B-cell lymphoma. And the prognostic ability of 25-(OH)D in these B-cell tumors such as mantle cell lymphoma, chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL) has also been demonstrated [11][12][13][14][15]24].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown that when the threshold was set at 50 nmol/L, the vitamin D de ciency rate ranged from 67%-88% [11,23], which mainly among B-cell lymphoma. And the prognostic ability of 25-(OH)D in these B-cell tumors such as mantle cell lymphoma, chronic lymphocytic leukemia (CLL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL) has also been demonstrated [11][12][13][14][15]24]. Until now, few studies have reported the relationship between vitamin D de ciency and the prognosis of T-cell lymphoma [14,16], and only one study included ENKTL patients, in which 38.6% of the ENKTL patients had below 10 ng/mL (25 nmol/L) of 25-(OH)D at diagnosis [16].…”

Section: Discussionmentioning

confidence: 99%

“…In terms of lymphoma, although studies have suggested that ultraviolet radiation has a protective effect on the development of lymphoma [6,7], but 25-(OH)D has no signi cant effect on the risk of lymphoma [6][7][8][9][10]. Nonetheless, several studies have shown that 25-(OH)D is signi cant in the prognostic evaluation of lymphoma [11][12][13][14][15]. Therefore, 25-(OH)D may be a good prognostic factor in lymphoma.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Value of 25‑Hydroxy Vitamin D in Extranodal NK/T Cell Lymphoma

Mao

Yin

Wang

et al. 2020

Preprint

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Abstract Background 25-hydroxy vitamin D [25-(OH)D] is widely used to determine vitamin D status in clinic. The aim of our study was to evaluate the prognostic value of 25-(OH)D in extranodal NK/T cell lymphoma (ENKTL). Materials and Methods Ninety-three ENKTL patients with available serum 25-(OH)D values were enrolled in our study. Vitamin D deficiency is defined as a 25-(OH)D below 50 nmol/L. Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). Subgroup analyses were performed to determine the applicable subgroups. Receiver operator characteristic (ROC) curves were plotted to estimate the accuracy of PINK-E (prognostic index of natural killer lymphoma added with Epstein-Barr virus-DNA status) and 25-(OH)D deficiency in ENKTL risk-stratification. Results Our results suggested that vitamin D deficiency was an independent inferior prognostic factor for both PFS [hazard ratio (HR), 2.869; 95% confidence interval (CI), 1.540 to 5.346; P = 0.003] and OS (HR, 3.204; 95%CI, 1.559 to 6.583; P = 0.006) in ENKTL patients with age ≤ 60, ECOG PS ≤ 1, stage III‒IV and PINK-E score ≥ 3. Additionally, we demonstrated that adding 25-(OH)D deficiency to PINK-E score system indeed has a superior prognostic significance than PINK-E alone for PFS [AUC: 0.796 (95% CI: 0.699 to 0.872) vs. 0.759 (95% CI: 0.659 to 0.841), P = 0.020] and OS [AUC: 0.755 (95% CI: 0.655 to 0.838) vs. 0.721 (95% CI: 0.618 to 0.809), P = 0.040]. Conclusion In conclusion, our study proved that 25-(OH)D deficiency was associated with inferior survival outcomes of ENKTL patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prognostic Value of 25‑Hydroxy Vitamin D in Extranodal NK/T Cell Lymphoma

Mao

Yin

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Prognostic value of 25-hydroxy vitamin D in extranodal NK/T cell lymphoma

et al. 2020

View full text Add to dashboard Cite

Background 25-hydroxy vitamin D [25-(OH)D] is widely used to determine vitamin D status in clinic. The aim of our study was to evaluate the prognostic value of 25-(OH)D in extranodal NK/T cell lymphoma (ENKTL). Materials and MethodsNinety-three ENKTL patients with available serum 25-(OH)D values were enrolled in our study. Vitamin D de ciency is de ned as a 25-(OH)D below 50 nmol/L. Univariate and multivariate regression analyses were performed to determine independent risk factors for progression-free survival (PFS) and overall survival (OS). Subgroup analyses were performed to determine the applicable subgroups. Receiver operator characteristic (ROC) curves were plotted to estimate the accuracy of PINK-E (prognostic index of natural killer lymphoma added with Epstein-Barr virus-DNA status) and 25-(OH)D de ciency in ENKTL risk-strati cation. ResultsOur results suggested that vitamin D de ciency was an independent inferior prognostic factor for both PFS [hazard ratio (HR), 2.869; 95% con dence interval (CI), 1.540 to 5.

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“…In human medicine, although the cause and effect relationship is not proven, the relationship between vitamin D status and diseases unrelated to bone metabolism has been extensively studied in recent years, and lower vitamin D concentrations has been associated with increased cancer incidence (Djurasinović et al, 2018;Yin et al, 2013); cardiovascular diseases, such as myocardial infarction (Giovannucci, Liu, Hollis, & Rimm, 2008), stroke and heart failure (Chowdhury et al, 2012;Muscogiuri et al, 2017), as well as autoimmune diseases (e.g., diabetes mellitus type I) (Pludowski et al, 2013), multiple sclerosis (Martinelli et al, 2014), rheumatoid arthritis (Kerr et al, 2011) and infectious diseases (White, 2008).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

Zafalon

Risolia

Pedrinelli

et al. 2019

Animal Physiology Nutrition

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Due to the presence of receptors in the cells of numerous body tissues, vitamin D is associated with several physiological functions that go beyond calcium and phosphorus homoeostasis and control of bone metabolism in the body. In humans, several studies have associated lower vitamin D concentrations with numerous diseases, such as cancer, heart disease, autoimmune diseases and infectious diseases, and also with an increase in the total mortality rate of the population. Recently, this nutrient started to gain importance in veterinary medicine, and several articles have shown a correlation between low vitamin D status and diseases unrelated to bone metabolism. The present review aims to highlight the recent publications that investigated this relationship, bringing the evidence that exists so far in dogs and cats. K E Y W O R D S1,25(OH)2D, 25(OH)D, calcidiol, calcitriol, cholecalciferol, hypovitaminosis D

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25(OH) vitamin D deficiency in lymphoid malignancies, its prevalence and significance. Are we fully aware of it?

Abstract: The prevalence of 25(OH)D deficiency in the analyzed group of patients with lymphoid malignancies is high and greater in malnourished individuals. Patients with pretreatment serum 25(OH)D < 19.6 nmol/l had a significantly shorter PFS.

Cited by 10 publications

References 30 publications

Prognostic Value of 25‑Hydroxy Vitamin D in Extranodal NK/T Cell Lymphoma

Prognostic Value of 25‑Hydroxy Vitamin D in Extranodal NK/T Cell Lymphoma

Prognostic value of 25-hydroxy vitamin D in extranodal NK/T cell lymphoma

Vitamin D metabolism in dogs and cats and its relation to diseases not associated with bone metabolism

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