Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors

Yang, Yang; Ji, Wei-gang; Zhu, Zhi-ru; Wu, Yan-Ling; Zhang, Zhiyang; Qu, Shao-chen

doi:10.1016/j.neuropharm.2018.03.007

Cited by 49 publications

(28 citation statements)

References 67 publications

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“…Taken together, all these findings suggest that Uncaria rhynchophylla display neuroprotective action in protecting neuronal damage through multiple pathways which could be due to the beneficial effect of active compounds as well as the combination effect of those compounds present in Uncaria rhynchophylla. Several studies have reported on the neuroprotective effect of alkaloid in Uncaria rhynchophylla such as hirsutine [187], rhynchophylline [188][189][190][191], and isorhynchophylline [192][193][194][195].…”

Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

129

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In recent years, natural products, which originate from plants, animals, and fungi, together with their bioactive compounds have been intensively explored and studied for their therapeutic potentials for various diseases such as cardiovascular, diabetes, hypertension, reproductive, cancer, and neurodegenerative diseases. Neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the progressive dysfunction and loss of neuronal structure and function that resulted in the neuronal cell death. Since the multifactorial pathological mechanisms are associated with neurodegeneration, targeting multiple mechanisms of actions and neuroprotection approach, which involves preventing cell death and restoring the function to damaged neurons, could be promising strategies for the prevention and therapeutic of neurodegenerative diseases. Natural products have emerged as potential neuroprotective agents for the treatment of neurodegenerative diseases. This review focused on the therapeutic potential of natural products and their bioactive compounds to exert a neuroprotective effect on the pathologies of neurodegenerative diseases.

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Section: Ginseng Ginseng Is a Perennial Herb Belonging To Thementioning

confidence: 99%

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Sairazi

Sirajudeen

2020

Evidence-Based Complementary and Alternative Medicine

129

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“…Rhynchophylline is a significant active compound that protects from deficits in spatial learning and memory induced by soluble Aβ oligomers. Moreover, rhynchophylline also prevents the hyperactivation of extrasynaptic NMDA receptors by reducing postsynaptic currents in AD mice [ 216 ]. Another medicinal plant Pulsatilla Chinensis contains a natural triterpenoid saponin compound anemoside A3 (AA3) that modulates synaptic connectivity and memory enhancement.…”

Section: Therapeutics For Admentioning

confidence: 99%

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

Bukke

Moola

Villani

et al. 2020

IJMS

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Alzheimer’s disease (AD) is an age-related dementia and neurodegenerative disorder, characterized by Aβ and tau protein deposition impairing learning, memory and suppressing synaptic plasticity of neurons. Increasing evidence suggests that there is a link between the glucose and glutamate alterations with age that down-regulates glucose utilization reducing glutamate levels in AD patients. Deviations in brain energy metabolism reinforce the development of AD by hampering glutamate levels in the brain. Glutamate is a nonessential amino acid and the major excitatory neurotransmitter synthesized from glucose. Alterations in cerebral glucose and glutamate levels precede the deposition of Aβ plaques. In the brain, over 40% of neuronal synapses are glutamatergic and disturbances in glutamatergic function have been implicated in pathophysiology of AD. Nevertheless, targeting the glutamatergic system seems to be a promising strategy to develop novel, improved therapeutics for AD. Here, we review data supporting the involvement of the glutamatergic system in AD pathophysiology as well as the efficacy of glutamatergic agents in this neurodegenerative disorder. We also discuss exciting new prospects for the development of improved therapeutics for this devastating disorder.

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“…Notoginsenoside R1 (NTR1) is the main active ingredient in Panax notoginseng , and NTR1 has been shown to protect cultured neurons from glutamate-induced excitotoxicity by modulating NMDA receptors that are composed of NR1/NR2B subunits, rather than NR1/NR2A subunits [ 90 ]. Rhynchophylline (RIN), a significant active component of Uncaria rhynchophylla , can prevent Aβ 1-42 -induced excitotoxicity in the dentate gyrus region, which is mediated by the excessive activation of extrasynaptic NR2B expression, and subsequent Ca 2+ overload [ 91 ]. These actions contribute to the neuroprotective effects of RIN on AD [ 91 ].…”

Section: Regulation Of Glutamate-mediated Signaling By the Natural Comentioning

confidence: 99%

“…Rhynchophylline (RIN), a significant active component of Uncaria rhynchophylla , can prevent Aβ 1-42 -induced excitotoxicity in the dentate gyrus region, which is mediated by the excessive activation of extrasynaptic NR2B expression, and subsequent Ca 2+ overload [ 91 ]. These actions contribute to the neuroprotective effects of RIN on AD [ 91 ]. RIN could also inhibit the persistent sodium current (I NaP ) and NMDA receptor current by downregulating Na v 1.6 and NR2B expression, and then RIN suppresses the neuronal hyperexcitability in several types of epilepsy [ 92 ].…”

Section: Regulation Of Glutamate-mediated Signaling By the Natural Comentioning

confidence: 99%

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

Liu

Wang

Kan

et al. 2020

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Glutamate is the major excitatory neurotransmitter in the central nervous system, and its signaling is critical for excitatory synaptic transmission. The well-established glutamate system involves glutamate synthesis, presynaptic glutamate release, glutamate actions on the ionotropic glutamate receptors (NMDA, AMPA, and kainate receptors) and metabotropic glutamate receptors, and glutamate uptake by glutamate transporters. When the glutamate system becomes dysfunctional, it contributes to the pathogenesis of neurodegenerative and neuropsychiatric diseases such as Alzheimer's disease, Parkinson's disease, depression, epilepsy, and ischemic stroke. In this review, based on regulating glutamate signaling, we summarize the effects and underlying mechanisms of natural constituents from Chinese herbal medicines on neurological disorders. Natural constituents from Chinese herbal medicine can prevent the glutamate-mediated excitotoxicity via suppressing presynaptic glutamate release, decreasing ionotropic and metabotropic glutamate receptors expression in the excitatory synapse, and promoting astroglial glutamate transporter expression to increase glutamate clearance from the synaptic cleft. However, some natural constituents from Chinese herbal medicine have the ability to restore the collapse of excitatory synapses by promoting presynaptic glutamate release and increasing ionotropic and metabotropic glutamate receptors expression. These regulatory processes involve various signaling pathways, which lead to different mechanistic routes of protection against neurological disorders. Hence, our review addresses the underlying mechanisms of natural constituents from Chinese herbal medicines that regulate glutamate systems and serve as promising agents for the treatment of the above-mentioned neurological disorders.

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Rhynchophylline suppresses soluble Aβ1-42-induced impairment of spatial cognition function via inhibiting excessive activation of extrasynaptic NR2B-containing NMDA receptors

Cited by 49 publications

References 67 publications

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

Chinese Herbal Medicine Interventions in Neurological Disorder Therapeutics by Regulating Glutamate Signaling

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