Chronic lymphocytic leukaemia and spontaneous rupture of spleen

Abstract

Pathological or spontaneous splenic rupture is a rare but well-recognised complication of haematological malignancies. The authors present a clinical report of a 78-year-old woman with known clinical history of chronic lymphocytic leukaemia and atrial fibrillation under anticoagulation with apixaban which has spontaneous splenic rupture. Pathological examination revealed lymph node and splenic infiltration due to chronic lymphocytic leukaemia. The diagnosis of splenic rupture must be considered in all patients with haematological malignancies who experience acute abdomen. Given the severity, it requires a correct and timely diagnosis.

Atraumatic splenic rupture after cocaine use and acute Epstein-Barr virus infection: A case report and review of literature

“…Splenic rupture is the leading cause of death in infectious mononucleosis and should be considered in any patient with abdominal pain and known or suspected acute EBV infection[15,16]. The presence of left shoulder pain in this setting is known as Kehr’s sign and is present in 17% of patients with ASR[17]. Diagnosis of infectious mononucleosis consists of appropriate clinical findings (the “classical triad” of fever, pharyngitis and lymphadenopathy) and serological evidence (detection of anti-viral capsid antigen IgM antibodies)[18].…”

Atraumatic Spleen and Liver Rupture While Weightlifting during Epstein-Barr Virus Convalescence

“…Symptoms of ASR and ALR, including vomiting, fatigue, nausea, and dizziness, also are nonspecific (13). Moreover, the classic symptoms of organ injury including upper quadrant abdominal pain and Kehr's sign (i.e., referred pain to the shoulder) only occur in up to 50% of patients with splenic rupture (7,14). In this report, we present a patient with a recent EBV infection who developed atraumatic rupture of the spleen and liver while weightlifting.…”

Impending splenic rupture as indicator of atypical chronic lymphocytic leukemia: A case report from Saudi Arabia

“…Spontaneous spleen rupture is a rare health condition, in which the spleen ruptures without associated injury [ 12 , 13 ]. According to the latest available data, this health condition is a complication of hematological diseases (30.3 %), inflammatory diseases (20 %), infectious diseases (27.3 %), drugs (9.2 %), mechanical disorders (6.8 %), and sometimes the absence of the cause was found (6.4 %).…”