A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range

Nachman, Einav; Clemensen, Peter; Santos, Katheryn; Cole, Alexis R.; Polizzotti, Brian D.; Hofmann, Grace; Leeman, Kristen T.; Bosch, Sarah J. van den; Kheir, John N.

doi:10.1213/ane.0000000000003308

Cited by 2 publications

(2 citation statements)

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“…There are various methods for measuring VO 2 . Indirect calorimetry has long been acknowledgement as a gold standard reference tool [ 14 ]. Mass spectroscopy also enables accurate measurements of VO 2 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

2023

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Background Body temperature (BT) is thought to have associations with oxygen consumption (VO2). However, there have been few studies in which the association between systemic VO2 and BT in humans was investigated in a wide range of BTs. The aims of this study were 1) to determine the association between VO2 and age and 2) to determine the association between VO2 and BT. Methods This study was a retrospective study of patients who underwent surgery under general anesthesia at a tertiary teaching hospital. VO2 was measured by the Dräger Perseus A500 anesthesia workstation (Dräger Medical, Lubeck, Germany). The associations of VO2 with age and BT were examined using spline regression and multivariable regression analysis with a random effect. Results A total of 7,567 cases were included in this study. A linear spline with one knot shows that VO2 was reduced by 2.1 ml/kg/min with one year of age (p < 0.001) among patients less than 18 years of age and that there was no significant change in VO2 among patients 18 years of age or older (estimate: 0.014 ml/kg/min, p = 0.08). VO2 in all bands of BT < 36.0 °C was not significantly different from VO2 in BT > = 36 °C and < 36.5 °C. Multivariable linear regression analysis showed that compared with VO2 in BT > = 36 °C and < 36.5 °C as a reference, VO2 levels were significantly higher by 0.57 ml/kg/min in BT > = 36.5 °C and < 37 °C (p < 0.001), by 1.8 ml/kg/min in BT > = 37 °C and < 37.5 °C (p < 0.001), by 3.6 ml/kg/min in BT > = 37.5 °C and < 38 °C (p < 0.001), by 4.9 ml/kg/min in BT > = 38 °C and < 38.5 °C (p < 0.001), and by 5.7 ml/kg/min in BT > = 38.5 °C (p < 0.001). The associations between VO2 and BT were significantly different among categorized age groups (p = 0.03). Conclusions VO2 increases in parallel with increase in body temperature in a hyperthermic state but remains constant in a hypothermic state. Neonates and infants, who have high VO2, may have a large systemic organ response in VO2 to change in BT.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

2023

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“…An important source of error in the clinical setting is the use of assumed VO 2 values, rather than direct measurement of VO 2 using mass spectrometry or another reference technique. Nachman et al have demonstrated a new device for clinical measurement of VO 2 in smaller children and infants, using compact engineering and laser‐ and infrared‐based quantification of oxygen and carbon dioxide, respectively. Future integration of such monitoring into anesthesia or intensive care ventilators will allow easy access to VO 2 data.…”

Section: Minimally Invasive Cardiac Output Measurementmentioning

confidence: 99%

Hemodynamic monitoring in children with heart disease: Overview of newer technologies

Skowno

2019

Pediatric Anesthesia

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A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range

Abstract: This device can measure VO2, VCO2, and EE with sufficient accuracy for clinical decision-making within the neonatal and pediatric size range, including in the setting of tachypnea or hyperoxia.

Cited by 2 publications

References 30 publications

RETRACTED ARTICLE: Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

RETRACTED ARTICLE: Associations of systemic oxygen consumption with age and body temperature under general anesthesia: retrospective cohort study

Hemodynamic monitoring in children with heart disease: Overview of newer technologies

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