Comparing the Efficacy of Peritonsillar Injection of Tramadol With Honey in Controlling Post-Tonsillectomy Pain in Adults

Hatami, Maryam; Mirjalili, M.A.; Ayatollahi, Vida; Vaziribozorg, Sedighe; Zand, Vahid

doi:10.1097/scs.0000000000004393

Cited by 7 publications

(3 citation statements)

References 11 publications

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“…One RCT tested acetaminophen plus 1 week of oral honey versus acetaminophen plus intraoperative tramadol for posttonsillectomy pain in adult patients. 28 The tramadol group had less pain than the honey group within the first 24 hours postoperatively, but there was no difference in pain score between groups at postoperative day (POD) 3 and 7. There was no difference in epithelialization of the tonsillar bed between the groups on POD 1 or 7, but the tonsillar bed healing status at POD 7 was rated better by the otolaryngologist in the honey group than in the tramadol group.…”

Section: Resultsmentioning

confidence: 86%

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Tharakan

Bent

Tavaluc

2018

Ann Otol Rhinol Laryngol

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Objectives: To provide an up-to-date review of honey’s effectiveness and potential applications in otorhinolaryngology. Methods: A literature search of the online databases PubMed, EMBASE, and Cochrane Central Register of Controlled Trials was conducted. Results: Sixty-three studies were identified within head and neck surgery (n = 23, 36%); pediatric otolaryngology (n = 18, 29%); rhinology, sinus, and skull base surgery (n = 11, 17%); otology (n = 6, 10%), facial plastic and reconstructive surgery (n = 3, 5%); and laryngology (n = 2, 3%). Studies included 6 meta-analyses, 44 randomized control trials, 5 case reports, and 8 animal models or in vitro studies. Of 55 clinical studies, 50 reported Level 1 evidence (prospective randomized control trials), and 5 reported Level 4 evidence (case series). The evidence level by subspecialty was: head and neck surgery (Level 1 n = 23), pediatrics (Level 1 n = 18), rhinology (Level 1 n = 7, level 4 n = 1), otology (Level 1 n = 1, Level 4 n = 3), facial plastics and reconstructive surgery (Level 4 n = 1), and laryngology (Level 1 n = 2). Conclusions: Honey can be used for a variety of otolaryngology conditions. The highest quality meta-analyses support oral honey for prevention and treatment of oral mucositis in cancer patients, cough associated with upper respiratory infection in children, and pain control after tonsillectomy. Further research will likely justify broader applications.

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Section: Resultsmentioning

confidence: 86%

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Tharakan

Bent

Tavaluc

2018

Ann Otol Rhinol Laryngol

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“…combination for pain control [17]. Curiously, Hatami and her co-authors suggested that honey and acetaminophen worked synergistically to regulate pain in their post-tonsillectomy patients [18]. Husband and Davis reported that diclofenac sodium given prior to surgery proved eff ective in reducing post-operative pain [19].…”

Section: Resultsmentioning

confidence: 99%

Adult post-tonsillectomy pain management: Opioid versus non-opioid drug comparisons

Bathula¹,

Noah²,

P³

2020

Arch Otolaryngol Rhinol

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Use of opium for pain control dates back to ancient times. When consumed, this narcotic drug enters the bloodstream and quickly attaches to proteins called opioid receptors on nerve cells in the brain, spinal cord, and other parts of the body. This process blocks pain sensations from the body, in part by stimulating the release of dopamine within the brain. Although very eff ective as pain suppressors, opioid drugs can be highly addictive, especially if they are used over a long period of time. They often have the undesired eff ect of convincing the brain that for contented survival higher and higher doses are needed daily. This evolutionary dependency is classically defi ned as an addiction.

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“…Honey might affect the local inflammation and thereby reduce und diminish duration of wound pain. The studies performed so far studying the effect of honey on postoperative pain after tonsillectomy revealed inconsistent results or did not used standard pain outcome measures [16,17,18,19,20,21,22,23,24,25].…”

Section: Introductionmentioning

confidence: 99%

The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study

et al. 2020

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Objective To analyze the effect of adjuvant oral application of honey for treating postoperative pain after tonsillectomy. Design Single centre prospective cohort study. Setting Two cohorts of patients after tonsillectomy. Participants 56 patients treated with honey 8 times per day (honey group), 18 patients treated without honey (control group); baseline analgesia were non-steroidal anti-inflammatory drugs (NSAID) or coxibs; opioids were used as pro re nata (PRN) medication; mean age 34.4 ± 13.4 years; 36% women. Main outcome measures On first to fifth postoperative day, patients rated their pain using the validated questionnaire of the German-wide project Quality Improvement in Postoperative Pain Treatment (QUIPS) including a numeric rating scale (NRS, 0-10) for determination of patient's pain. QUIPS allows standardized assessment of patients' characteristics andpain-associated patientreported outcomes (PROs). The influence of preoperative and postoperative parameters on patients' postoperative pain were estimated by univariate and multivariate statistical analysis.

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Comparing the Efficacy of Peritonsillar Injection of Tramadol With Honey in Controlling Post-Tonsillectomy Pain in Adults

Cited by 7 publications

References 11 publications

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Honey as a Treatment in Otorhinolaryngology: A Review by Subspecialty

Adult post-tonsillectomy pain management: Opioid versus non-opioid drug comparisons

The effect of adjuvant oral application of honey in the management of postoperative pain after tonsillectomy in adults: A pilot study

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