Myxoid-round cell liposarcoma: MRI appearance after radiation therapy and relationship to response

Rosenberg, Michael S.; Groth, John V.; Taljanovic, Mihra S.; Mar, Woongchon

doi:10.1016/j.radcr.2017.06.017

Cited by 2 publications

(1 citation statement)

References 7 publications

(25 reference statements)

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“…The myxoid variant accounts for one-third to one-half of all liposarcomas, commonly occurring in a younger demographic with a peak incidence in the fifth decade, in comparison to the dedifferentiated and well-differentiated subtypes which demonstrate peak incidence in the seventh decade. The most common sites of tumor involvement include the lower extremities with a predilection for the medial thigh and popliteal area [10].…”

Section: Discussionmentioning

confidence: 99%

A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report

Alawad

Alhaj

Ghazal

et al. 2019

International Journal of Surgery Case Reports

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HighlightsComplete surgical resection of liposarcoma is central in treatment based on grade.Radiation reduces risk of local recurrence or minimize surgical morbidity in the highly radiosensitive myxoid/round cell liposarcoma group.Chemotherapy is utilized in chemosensitive histologies with metastatic potential.Understanding of the genetic aberrations allows development of targeted therapies for liposarcoma.

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Section: Discussionmentioning

confidence: 99%

A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report

Alawad

Alhaj

Ghazal

et al. 2019

International Journal of Surgery Case Reports

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Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas

Kousi

Messiou

Miah

et al. 2021

The British Journal of Radiology

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Objectives: Myxoid liposarcomas (MLS) show enhanced response to radiotherapy due to their distinctive vascular pattern and therefore could be effectively treated with lower radiation doses. This is a descriptive study to explore the use of functional MRI to identify response in a uniform cohort of MLS patients treated with reduced dose radiotherapy Methods: 10 patients with MLS were imaged pre-, during, and post-radiotherapy receiving reduced dose radiotherapy and the response to treatment was histopathologically assessed post-radiotherapy. Apparent diffusion coefficient (ADC), T2* relaxation time, volume transfer constant (Ktrans), initial area under the gadolinium curve over 60 s (IAUGC60) and (Gd) were estimated for a central tumour volume. Results: All parameters showed large inter- and intrasubject variabilities. Pre-treatment (Gd), IAUGC60 and Ktrans were significantly different between responders and non-responders. Post-radiotherapy reductions from baseline were demonstrated for T2*, (Gd), IAUGC60 and Ktrans for responders. No statistically significant ADC differences were demonstrated between the two response groups. Significantly greater early tumour volume reductions were observed for responders. Conclusions: MLS are heterogenous lesions, characterised by a slow gradual contrast-agent uptake. Pre-treatment vascular parameters, early changes to tumour volume, vascular parameters and T2* have potential in identifying response to treatment. The delayed (Gd) is a suitable descriptive parameter, relying simply on T1 measurements. Volume changes precede changes in MLS functionality and could be used to identify early response. Advances in knowledge: MLS are are characterised by slow gradual contrast-agent uptake. Measurement of the delayed contrast-agent uptake (Gd) is simple to implement and able to discriminate response.

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Myxoid-round cell liposarcoma: MRI appearance after radiation therapy and relationship to response

Cited by 2 publications

References 7 publications

A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report

A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report

Descriptive analysis of MRI functional changes occurring during reduced dose radiotherapy for myxoid liposarcomas

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