A Young Boy With Persistent Nodules And Hoarseness: A Rare Presentation Of Nodular Secondary Syphilis

Abstract

Syphilis is a venereal disease caused by treponema pallidum, historically known as "great mimicker" because of its variable presentations. Secondary syphilis usually presents with maculopapular or papulosquamous rash. Rare manifestations include papulonodular, annular and lichenoid lesions. Nodules are usually found in benign tertiary syphilis. We present a case of a young boy who presented with five months' history of nodular skin lesions and hoarseness of voice. Venereal disease research laboratory (VDRL) was initially negative owing to prozone phenomenon. However, histopathology was confirmatory and he responded to benzathine penicillin. We present this case because of rare clinical presentation with persistent nodular lesions, unusual age group, and negative initial VDRL test.

Cholesterol homeostasis: Links to hair follicle biology and hair disorders

“…What is more, VDR knockout in mice prevents initiation of new hair cycles following morphogenesis . Evidence also suggests vitamin D deficiency is associated with female hair loss disorders and AA . Hair growth was shown to increase with the presence of synthetic vitamin D3 analogues (calcitriol/calcipotriol) in alopecia totalis, AA and in chemotherapy‐induced alopecia mouse models .…”

“…[172] Evidence also suggests vitamin D deficiency is associated with female hair loss disorders [170] and AA. [174][175][176] Hair growth was shown to increase with the presence of synthetic vitamin D3 analogues (calcitriol/calcipotriol) in alopecia totalis, [177] AA [178] and in chemotherapy-induced alopecia mouse models. [179] It could be suggested that dysfunction in the cholesterol biosynthesis pathway, which would alter levels of 7-DHC, might play a role in hair loss related to vitamin D3 deficiency.…”

A rare case of secondary syphilis presenting with extensive cutaneous nodules and generalised lymphadenopathy

“…The rare clinical manifestations of the disease are usually observed in patients with HIV infection (9). Nevertheless, the patient presented here did not have any coinfections like active hepatitis B, hepatitis C, HSV1, HSV2 or HIV infection.…”

“…The World Health Organization recommends benzathine penicillin G 2.4 million units once intramuscularly in the treatment of early syphilis (8). Besides, patients with nodular secondary syphilis who were treated with administration of benzathine penicillin G 2.4 million units weekly for two or three weeks have been reported (Table 1) (1)(2)(3)(4)6,7,9).…”

Effect of governor vessel moxibustion (GVM) therapy with mild to moderate psoriasis: A randomized clinical trial

“…PS impacts the physical and mental health of patients, especially when it is associated with cardiovascular disease, obesity, mental and emotional issues, or other diseases. [1][2][3] Both the occurrence and development of PS are related to heredity, immunity, infection, metabolism, and other factors. [4] Immune dysfunction and interactions in the inflammatory cytokine network contribute significantly to PS pathogenesis and thus form an essential theoretical foundation for the prevention and treatment of the disorder.…”