The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population

Isakova, Jainagul; Talaibekova, Elnura; Vinnikov, Denis; Aldasheva, Nazira; Mirrakhimov, Aibek E.; Aldashev, Almaz

doi:10.1186/s12902-018-0242-6

Cited by 8 publications

(3 citation statements)

References 17 publications

(36 reference statements)

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“…Isakova et al investigating Kyrgyz population reported that the Val/Val genotype was significantly more prevalent in the patients with abdominal obesity than in the healthy controls (OR = 3.12). However, the allelic variants of Omentin Val 109 Asp polymorphism did not correlate with abdominal obesity [34].…”

Section: Discussionmentioning

confidence: 99%

Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

et al. 2019

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Background Insulin resistance (IR) and fat accumulation in visceral adipose tissue are key players in developing type 2 diabetes (T2D). Several adipose tissue derived-gene polymorphisms are related to higher body mass index (BMI), insulin resistance and T2D. The association of omentin rs2274907 (Val109Asp) and fat-mass and obesity-associated (FTO) rs9939609 gene polymorphisms with overweight/obesity and T2D is controversial. The aim of this study was to determine the association between omentin Val109Asp and FTO rs9939609 polymorphisms and insulin resistance in newly-diagnosed T2D patients. Methods The case-control study included 83 newly-diagnosed T2D patients and 85 healthy matched controls, aged 20–80 years. Fasting blood glucose and insulin levels were measured by the enzymatic method and enzyme-linked-immunosorbent assay, respectively. Insulin resistance was calculated using the homeostasis model assessment (HOMA) index. Genotyping was examined using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results There are significant differences between both omentin Val109Asp and FTO rs9939609 polymorphisms and studied individuals ( P = 0.011 and P = 0.0001, respectively). Both genetic polymorphisms of omentin Val109Asp and FTO rs9939609 (T/A) are significantly related to higher HOMA index ( P = 0.030 and P = 0.046, respectively). However, omentin Val109Asp polymorphism was only related to individuals who were overweight/obese. Additionally, both omentin Val109Asp and FTO rs9939609 polymorphisms were significantly positively correlated to familial history of diabetes ( P = 0.046 and P = 0.024, respectively). Conclusions Omentin V109D and FTO rs9939609 genetic variations may change insulin metabolism and have key roles in developing T2D through insulin resistance. Thus, the evaluation of these polymorphic regions may be helpful for predicting type 2 diabetes.

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Section: Discussionmentioning

confidence: 99%

Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

et al. 2019

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“…Omentin is encoded in humans by the ITLN1 gene and located within the 1q22-q23 chromosomal region. The common rs2274907 polymorphism of the omentin gene exists a polymorphic locus in position 326 of the fourth exon, where adenine is replaced with thymine (326 GAC→GTC, rs2274907), which entails the replacement of aspartic acid with valine in position 109 of ITLN1 (Val109Asp) (Isakova et al 2018). The previous studies found an association of this omentin gene rs2274907 with daily energy intake (Splichal et al 2015), cardiovascular diseases (Jamshidi et al 2017), and type 2 diabetes (Rathwa et al 2019).…”

Section: Introductionmentioning

confidence: 99%

Association of Omentin rs2274907 Gene Polymorphism and Its Protein on the Risk of Obesity and Metabolic Disorder in Thai Children

Pheungruang¹,

Suriyaprom²,

Tungtrongchitr³

et al. 2022

Philipp J Sci

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Omentin is an adipocytokine that expresses in white adipose tissues. It is a marker for preventing the development of pro-inflammatory states related to diseases like obesity. This study aimed to examine the concentrations of omentin and anthropometric-biochemical parameters in obese children and healthy controls. Also, to search for the associations of omentin rs2274907 gene polymorphism with omentin levels and obesity among Thai children. A total of 293 children, 178 obese cases and 115 healthy controls, were recruited for this study. The omentin level was measured using the enzyme- linked immunosorbent assay (ELISA), and genotyping was performed using the polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) method. Serum omentin levels were significantly lower in the obese group than in the control group (13.9 and 25.0 ng/mL, respectively, p < 0.001). The omentin levels had significant negative correlation with body weight, body mass index (BMI) percentile, waist circumference, triglycerides (r = –0.276, –0.275, –0.259, –0.242, p < 0.001), and had positive correlation with high-density lipoprotein cholesterol (HDL-C) levels (r = 0.210, p < 0.001). There was a significant association between obesity and serum omentin levels (p < 0.05). However, the omentin rs2274907 gene polymorphism showed no significant relationship with the omentin levels and obesity among Thai children. These findings in Thai children suggest that omentin level, but not omentin rs2274907 gene polymorphism, may influence susceptibility to obesity.

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“…Obesity is caused by energy imbalance: when the energy gained from calories is greater than the energy expended from physical activity; the body stores the extra calories as fat (Alharbi et al, 2017). There is an increased prevalence of being overweight and obesity globally (Isakova et al, 2018). Per the World Health Organization (WHO), the global prevalence of obesity in adults is 13%, and it is 18% in children aged 5–19 years (Aguayo-Armendáriz et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Screening for obesity in the offspring of first-cousin consanguineous couples: A Phase-I study in Saudi Arabia

Alharbi

Al‐Sheikh

Alsaadi

et al. 2020

Saudi Journal of Biological Sciences

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Consanguineous or cousin marriages are very common in Saudi Arabia. However, owing to limited studies and insufficient knowledge about genetic diseases/disorders, many couples are unaware of the increased health risks for their offspring. Among the inherited and complex diseases from parents’ consanguinity, obesity is common; therefore, we examined the prevalence of obesity in the offspring of first-cousin consanguineous couples in Saudi Arabia. In this questionnaire-based study, 657 individuals (mean age = 18.7 ± 10.2 years; age range = 2–65 years) who were residing in Riyadh, Saudi Arabia participated. Among them, almost 90% were native Saudis. Participants mean body mass index (BMI) was 24.5 ± 9.1 kg/m2. Sex- stratified demographic details confirmed a significant association between age and BMI (p < .001). We confirmed that adolescents and adults were more prone to develop obesity. Adults and non-Saudi participants were three times more likely to develop obesity if they had first-cousin consanguineous parents than those who did not. Of the 30% of participants who were obese, 100 will be selected for Phase II, in which we plan to perform exome sequencing.

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The association of Val109Asp polymorphic marker of intelectin 1 gene with abdominal obesity in Kyrgyz population

Abstract: Significant increase in the frequency of Val109Val genotype of ITLN1 gene in AO patients may be indicative of some potential role of ITLN1 gene in molding genetic predisposition to AO in the Kyrgyz. This requires further elaboration in the future studies.

Cited by 8 publications

References 17 publications

Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

Association of Omentin rs2274907 and FTO rs9939609 gene polymorphisms with insulin resistance in Iranian individuals with newly diagnosed type 2 diabetes

Association of Omentin rs2274907 Gene Polymorphism and Its Protein on the Risk of Obesity and Metabolic Disorder in Thai Children

Screening for obesity in the offspring of first-cousin consanguineous couples: A Phase-I study in Saudi Arabia

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