Bioactive leptin is stronger related to parameters of fat mass and distribution than conventionally measured leptin: Findings from a longitudinal study in obese children participating in a lifestyle intervention

Niklowitz, Petra; Rothermel, Juliane; Lass, Nina; Barth, Alfred; Reinehr, Thomas

doi:10.1016/j.cca.2018.02.020

Cited by 6 publications

(19 citation statements)

References 25 publications

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“…We randomly chose 41 German children with obesity who participated in the lifestyle intervention ‘Obeldicks’ with substantial weight reduction and 41 German children with obesity without changes of weight status during this intervention matched for age, sex and degree of overweight. Details of the recruitment process have been published earlier . The data of body composition and leptin measurements (bioactive leptin and conventional leptin) have been published earlier .…”

Section: Methodsmentioning

confidence: 99%

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Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

et al. 2019

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Objective The adipokine omentin‐1 has been suggested to be inversely associated with obesity and insulin resistance in humans. We studied the relationships between omentin‐1, parameters of fat mass, insulin resistance, lipids and blood pressure in children with obesity in a longitudinal study. Methods We analysed omentin‐1 concentrations in 23 normal‐weight children and in 82 children with obesity participating in a one‐year lifestyle intervention. In the children with obesity, omentin‐1, bioactive and conventional leptin, thyroid hormones (thyroid‐stimulating hormone, free thyroxine 4, free triiodothyronine), body mass index, waist circumference, body fat based on skin‐fold measurements and bioimpedance analyses, lipids, insulin resistance as homeostatic model assessment of insulin resistance (HOMA‐IR) and blood pressure were determined at baseline and 1 year later. Furthermore, we measured omentin‐1 concentrations 1 year after the end of the lifestyle intervention. Results The omentin‐1 concentrations were significantly (P = .008) lower in children with obesity compared to normal‐weight children (296 ± 108 ng ml−1 vs. 232 ± 99 ng ml−1). Omentin‐1 concentrations increased significantly (P < .001) in children with obesity and substantial weight loss (35 ± 55 ng ml−1), while omentin‐1 concentrations did not change significantly (P = .750) in children with obesity without weight loss (−5 ± 108 ng ml−1) during the intervention. Substantial weight loss after the end of intervention led to a significant (P < .001) increase of omentin‐1 concentrations (+64 ± 14 ng ml−1). Omentin‐1 was significantly and negatively associated with HOMA‐IR both in cross‐sectional (r = −.27, P = .006) and longitudinal analyses (r = −.33, P = .001). Omentin‐1 concentrations were not related to pubertal stage, sex or thyroid hormones. Conclusions Our data do support the hypothesis that omentin‐1 is reversibly decreased in obesity and is a link between obesity and insulin resistance.

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Section: Methodsmentioning

confidence: 99%

“…Details of the recruitment process have been published earlier . The data of body composition and leptin measurements (bioactive leptin and conventional leptin) have been published earlier . Six children of that published cohort were not analysed in this study since no unthawed frozen serum was available.…”

Section: Methodsmentioning

confidence: 99%

Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

et al. 2019

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“…The strengths of our study are the longitudinal design analyzing the changes of progranulin and parameters of the MetS both during and after the end of a lifestyle intervention, the analyses of children naïve to drugs or other diseases, and the measurement of bioactive leptin, which is stronger related to fat mass than conventionally measured leptin . However, this study has a few potential limitations.…”

Section: Discussionmentioning

confidence: 99%

“…Leptin measurements were performed with the “human functional leptin = bioLep ELISA” (L07; Mediagnost, Reutlingen, Germany, http://www.mediagnost.de). Since bioleptin correlated stronger with fat mass than conventionally measured leptin, we evaluated bioleptin levels. The intraassay CVs are ≤5%, the interassay CVs are ≤9%, the least‐detectable concentrations are <0.01 ng/mL …”

Section: Methodsmentioning

confidence: 99%

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Is there a link between progranulin, obesity, and parameters of the metabolic syndrome in children? Findings from a longitudinal intervention study

et al. 2019

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Background The inflammatory cytokine progranulin has been proposed to play a role in obesity and its associated comorbidities such as insulin resistance. Objective In a longitudinal study, we analyzed the links between progranulin, parameters of fat mass, insulin resistance, and metabolic syndrome (MetS) in obese children. Methods We measured the following parameters in 88 obese children at baseline, at the end of a 1‐year lifestyle intervention and 1‐year later (=2 years after baseline): progranulin, bioactive leptin, body mass index‐SD score (BMI‐SDS), waist circumference, body fat based on skinfold measurements and bioimpedance analyses, lipids, transaminases, insulin resistance index homeostasis model assessment (HOMA), and blood pressure. As a control, we determined progranulin in 23 normal‐weight children. Results The progranulin concentrations did not differ significantly (P = .795) between obese and normal‐weight children. Progranulin concentrations decreased significantly during and after the lifestyle intervention in children with and without decrease of BMI‐SDS. There was no relationship between progranulin concentrations and pubertal stage or gender. Progranulin was not significantly associated with insulin resistance HOMA, parameters of the MetS or transaminases both in cross‐sectional and longitudinal multiple linear regression analyses adjusted to multiple confounders. Progranulin was significantly, negatively related to age (b‐coefficient −1.24 ± .97, P = .012, r2 = .07). Conclusions Our data do not support the hypothesis that progranulin is an important link between obesity, insulin resistance, and MetS in childhood.

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Serum adipokines and metabolic indicators in girls with Turner syndrome

Kawada

2019

Cytokine

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Bioactive leptin is stronger related to parameters of fat mass and distribution than conventionally measured leptin: Findings from a longitudinal study in obese children participating in a lifestyle intervention

Cited by 6 publications

References 25 publications

Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

Link between omentin‐1, obesity and insulin resistance in children: Findings from a longitudinal intervention study

Is there a link between progranulin, obesity, and parameters of the metabolic syndrome in children? Findings from a longitudinal intervention study

Serum adipokines and metabolic indicators in girls with Turner syndrome

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