Oral health in Alzheimer’s disease: a multicenter case-control study

Aragon, Flávio Ferrari; Zea‐Sevilla, María Ascensión; Montero, Javier; Sancho, Pilar; Corral, Rocío; Tejedor, Carmen; Frades-Payo, Belén; Paredes-Gallardo, Vanessa; Albaladejo, Alberto

doi:10.1007/s00784-018-2396-z

Cited by 55 publications

(85 citation statements)

References 30 publications

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“…Oral lesions, like candidiasis, angular cheilitis, and others, such as ulcerations and stomatitis, have also been reported as being more frequently observed in older adults with dementia when compared to older adults without dementia. The same trend applies to xerostomia …”

Section: Oral Health Status Among Patients With Alzheimer's Diseasementioning

confidence: 99%

“…These conditions are common among older adults in general and, consequently among older adults with Alzheimer's disease, who present with these oral health conditions even before the onset of Alzheimer's disease. Poor oral hygiene, mainly due to the above mentioned general health and social support factors, is also a common oral health‐related ROHD risk factor among older adults with Alzheimer's disease …”

Section: Oral Health Status Among Patients With Alzheimer's Diseasementioning

confidence: 99%

“…Older adults with dementia currently still present with poor oral health conditions in epidemiologic studies. 9,10,42,43 When comparing dental hard tissues related problems between older adults with and without dementia, a recent systematic review 13 demonstrated that available data suggest that total edentulism is similar between the two groups, as well as number of teeth and decayed/missing/filled teeth index (DMFT) index. However, older adults with dementia presented with more coronal and root caries, as well as more retained root tips.…”

Section: Epidemiologymentioning

confidence: 99%

“…The same trend applies to xerostomia. 9,12 Few studies have focused on orofacial pain among older adults with dementia, and its prevalence was reported to range between 7.4 and 25.7%. 13,42 As for self-perceived oral health, recent studies have reported that older adults with dementia reported similar Geriatric Oral Health Assessment Index (GOHAI) scores than the patients without dementia, although patients with dementia presented with poorer oral health.…”

Section: Epidemiologymentioning

confidence: 99%

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Oral health care for patients with Alzheimer's disease: An update

Marchini

Ettinger

Caprio

et al. 2019

Special Care in Dentistry

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Alzheimer's disease and related disorders (ADRD) are among the age‐associated chronic conditions that are most challenging to health care systems around the globe, as patients with dementia require full‐time, intensive care for multiple years. Oral health care is negatively impacted by cognitive decline, and consequently poor oral health is common among people with ADRD. Poor oral health status is linked with many undesirable consequences for the well‐being of people with ADRD, from excruciating local pain to life‐threatening conditions, as aspiration pneumonia. In this paper, the authors provide an update on the most current concepts about Alzheimer's disease epidemiology, etiology, and management, current oral health care for patients with Alzheimer's disease, oral health promotion strategies for this population, as well as current research and future direction for improving oral health care for patients with Alzheimer's disease. It concludes that oral health care should be included in the patient's routine health care as early as possible in the progression of Alzheimer's disease for preventing rapid oral health deterioration. Establishing oral hygiene routines and providing dental treatment that is customized to the patients’ individual needs and disease stage are important to achieve good oral health outcomes and prevent quality of life decline.

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Section: Oral Health Status Among Patients With Alzheimer's Diseasementioning

confidence: 99%

Section: Oral Health Status Among Patients With Alzheimer's Diseasementioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

See 2 more Smart Citations

Oral health care for patients with Alzheimer's disease: An update

Marchini

Ettinger

Caprio

et al. 2019

Special Care in Dentistry

View full text Add to dashboard Cite

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“…One study showed that patients with AD had bad oral health in comparison to a healthy age‐matched group. Patients with AD had more caries, periodontal disease, candidiasis, and salivary quantity and quality changes . In our study, we did not evaluate mucosal lesions, and all patients were edentulous.…”

Section: Discussionmentioning

confidence: 79%

Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case–control study

Ahmadi‐Motamayel

Goodarzi

Tarazi

et al. 2018

Special Care in Dentistry

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Aim:The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Up to 90% decrease in AChE activity has been observed in AD. Methods and results:Thirty healthy subjects and 30 patients with AD participated in this study. Saliva samples were collected from 8 to 10 AM. AChE and PChE of saliva were assessed by the Ellman method. Statistical comparison was performed using SPSS 16 for t-test. The activity of AChE and PChE significantly increased in the group with AD compared to the healthy subjects. Sex had no effect on the activities of these enzymes. No correlation existed between the duration of illness and enzymatic activity. The enzyme levels reduced with age.Conclusion: AChE and PChE levels were increased in saliva samples of patients with AD. Therefore, saliva has the potential for being used for the purpose of biomarker evaluation to replace cerebrospinal fluid in patients with AD.

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Assessment of Oral Functions

2021

Dental Neuroimaging

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Oral health in Alzheimer’s disease: a multicenter case-control study

Abstract: Clinicians should be aware of the implications of Alzheimer's disease in oral health, in order to stablish the effective preventive measures and the optimal treatment plan.

Cited by 55 publications

References 30 publications

Oral health care for patients with Alzheimer's disease: An update

Oral health care for patients with Alzheimer's disease: An update

Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case–control study

Assessment of Oral Functions

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