Citrobacter freundii impairs the phosphoryl transfer network in the gills of Rhamdia quelen: Impairment of bioenergetics homeostasis

Baldissera, Matheus D.; Souza, Carine F.; Guerino, B.; Moreira, Karen L.S.; Veiga, Marcelo Leite da; Rocha, Maria Izabel de Ugalde Marques da; Baldisserotto, Bernardo

doi:10.1016/j.micpath.2018.02.040

Cited by 10 publications

(3 citation statements)

References 17 publications

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“…As an opportunistic pathogen, Citrobacter mainly causes significant opportunistic infections in humans [ 61 ]. The Citrobacter pathogenic strains can also cause septicemia and death in aquatic organisms such as Rhamdia quelen [ 62 ]. It is speculated that Citrobacter can cause disease in the crayfish.…”

Section: Discussionmentioning

confidence: 99%

Developmental, Dietary, and Geographical Impacts on Gut Microbiota of Red Swamp Crayfish (Procambarus clarkii)

et al. 2020

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Red swamp crayfish (Procambarus clarkii) breeding is an important economic mainstay in Hubei province, China. However, information on the gut microbiota of the red swamp crayfish is limited. To address this issue, the effect of developmental stage, diet (fermented or non-fermented feed), and geographical location on the gut microbiota composition in the crayfish was studied via high-throughput 16S rRNA gene sequencing. The results revealed that the dominant phyla in the gut of the crayfish were Proteobacteria, Bacteroidetes,Firmicutes, Tenericutes, and RsaHF231. The alpha diversity showed a declining trend during development, and a highly comparable gut microbiota clustering was identified in a development-dependent manner. The results also revealed that development, followed by diet, is a better key driver for crayfish gut microbiota patterns than geographical location. Notably, the relative abundance of Bacteroidetes was significantly higher in the gut of the crayfish fed with fermented feed than those fed with non-fermented feed, suggesting the fermented feed can be important for the functions (e.g., polysaccharide degradation) of the gut microbiota. In summary, our results revealed the factors shaping gut microbiota of the crayfish and the importance of the fermented feed in crayfish breeding.

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Section: Discussionmentioning

confidence: 99%

Developmental, Dietary, and Geographical Impacts on Gut Microbiota of Red Swamp Crayfish (Procambarus clarkii)

et al. 2020

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“…The outbreak and spread of bacterial infections in aquaculture farms pose a major concern. C. freundii is an opportunistic pathogen that is commonly found in water, soil, animals and has been reported to cause numerous diseases in aquaculture [ 39 , 40 , 41 ]. In recent years, an increasing number of studies reported C. freundii causing diseases and serious mass deaths in various aquatic products, such as Chinese mitten-handed crab [ 42 ], red swamp crayfish [ 14 ], grass carp [ 24 ], and crucian carp [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

A Novel Disease (Water Bubble Disease) of the Giant Freshwater Prawn Macrobrachium rosenbergii Caused by Citrobacter freundii: Antibiotic Treatment and Effects on the Antioxidant Enzyme Activity and Immune Responses

et al. 2022

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The giant freshwater prawn, Macrobrachium rosenbergii, is an important and economical aquaculture species widely farmed in tropical and subtropical areas of the world. A new disease, “water bubble disease (WBD)”, has emerged and resulted in a large loss of M. rosenbergii cultured in China. A water bubble with a diameter of about 7 mm under the carapace represents the main clinical sign of diseased prawns. In the present study, Citrobacter freundii was isolated and identified from the water bubble. The optimum temperature, pH, and salinity of the C. freundii were 32 °C, 6, and 1%, respectively. A challenging experiment showed that C. freundii caused the same typical signs of WBD in prawns. Median lethal dose of the C. freundii to prawn was 104.94 CFU/g. According to the antibiogram tests of C. freundii, florfenicol and ofloxacin were selected to evaluate their therapeutic effects against C. freundii in prawn. After the challenge with C. freundii, 86.67% and 72.22% survival of protective effects against C. freundii were evaluated in the oral florfenicol pellets and oral ofloxacin pellets feding prawns, respectively, whereas the mortality of prawns without fed antibiotics was 93%. After antibiotic treatment and C. freundii infection, the activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), malondialdehyde (MDA), acid phosphatase (ACP), alkaline phosphatase (ALP), and lysozyme (LZM) in the hemolymph and hepatopancreas of the prawns and the immune-related gene expression levels of Cu/Zn-SOD, CAT, GPx, GST, LZM, ACP, anti-lipopolysaccharide factor, crustin, cyclophilin A, and C-type lectin in hepatopancreas were all significantly changed, indicating that innate immune responses were induced by C. freundii. These results can be beneficial for the prevention and control of C. freundii in prawns.

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“…Citrobacter freundii is closely related to E.coli and Salmonella and is prevalent in diverse ecological niches such as soil, water, sewage, food and the gut of animals including humans ( Knirel et al, 2002 ; Murray et al, 2010 ; Abbott, 2011 ; Bandeira Junior et al, 2018 ). Citrobacter freundii , a causative agent of gastroenteritis and hemorrhagic septicemia, is a common pathogen of diverse freshwater fish where infected fish show symptoms such as skin ulceration, systemic infectious signs on the liver, kidney, muscles and gills ( Jeremić et al, 2003 ; Baldissera et al, 2018 ; Sun et al, 2018 ).…”

Section: Proteobacteria (Class: Gammaproteobacteria)mentioning

confidence: 99%

Secretion Systems in Gram-Negative Bacterial Fish Pathogens

Mekasha

Linke

2021

Front. Microbiol.

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Bacterial fish pathogens are one of the key challenges in the aquaculture industry, one of the fast-growing industries worldwide. These pathogens rely on arsenal of virulence factors such as toxins, adhesins, effectors and enzymes to promote colonization and infection. Translocation of virulence factors across the membrane to either the extracellular environment or directly into the host cells is performed by single or multiple dedicated secretion systems. These secretion systems are often key to the infection process. They can range from simple single-protein systems to complex injection needles made from dozens of subunits. Here, we review the different types of secretion systems in Gram-negative bacterial fish pathogens and describe their putative roles in pathogenicity. We find that the available information is fragmented and often descriptive, and hope that our overview will help researchers to more systematically learn from the similarities and differences between the virulence factors and secretion systems of the fish-pathogenic species described here.

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Citrobacter freundii impairs the phosphoryl transfer network in the gills of Rhamdia quelen: Impairment of bioenergetics homeostasis

Cited by 10 publications

References 17 publications

Developmental, Dietary, and Geographical Impacts on Gut Microbiota of Red Swamp Crayfish (Procambarus clarkii)

Developmental, Dietary, and Geographical Impacts on Gut Microbiota of Red Swamp Crayfish (Procambarus clarkii)

A Novel Disease (Water Bubble Disease) of the Giant Freshwater Prawn Macrobrachium rosenbergii Caused by Citrobacter freundii: Antibiotic Treatment and Effects on the Antioxidant Enzyme Activity and Immune Responses

Secretion Systems in Gram-Negative Bacterial Fish Pathogens

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