Contribution of 3-T Susceptibility-Weighted MRI to Detection of Intraarticular Hemosiderin Accumulation in Patients With Hemophilia

Akyuz, Behic; Polat, Ahmet Veysel; Öztürk, Mesut; Aslan, Kerim; Tomak, Leman; Selçuk, Mustafa Bekir

doi:10.2214/ajr.17.18594

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Hemosiderin was identified histologically with Perls’ Prussian-blue stain, where iron in hemosiderin turns blue to black when exposed to potassium ferrocyanide. Since hemosiderin is an iron-storage complex (denatured ferritin and other material), which is marker of organ damage associated with hemorrhages [54, 55].…”

Section: Methodsmentioning

confidence: 99%

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Takata

et al. 2020

Preprint

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Intraventricular hemorrhage (IVH) is the most fatal form of brain injury, yet a therapy directed at ameliorating intraventricular clot is very limited. There is accumulating evidence that an augmentation of the meningeal lymphatic (MLVs) functions might be a promising therapeutic target for IVH. In particular, the photostimulation (PS) of MLVs could be promising for non-invasive therapy of IVH via PS of clearance of red blood cells (RBCs) from the brain via MLVs. Indeed, we uncover that PS has therapeutic effects on IVH in mice reducing the mortality, improving the emotional status, accelerating the RBCs evacuation from the ventricles and increasing the ICP recovery. Our findings strongly suggest that the PS-mediated stimulation of drainage and clearing functions of MLVs can be a novel bedside, readily applicable and commercially viable technologies for treatment of IVH. These pilot results open new horizons in a non-invasive therapy of IVH via PS stimulation of regenerative lymphatic mechanisms.

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Section: Methodsmentioning

confidence: 99%

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Takata

et al. 2020

Preprint

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“…Recent studies explored musculoskeletal applications of SWI mainly on calcific tendinopathy, meniscal imaging, and hemophilic arthropathy. 10,11 Diffuse T2 Hypointense Bone Tumors and Tumor-like Lesions…”

mentioning

confidence: 99%

T2-weighted Hypointense Tumors and Tumor-like Lesions

Papakonstantinou

Isaac

Dalili

et al. 2019

Semin Musculoskelet Radiol

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Most musculoskeletal tumors are hyperintense on T2-weighted images. However, some T2-weighted hypointense tumors and tumor-like lesions are encountered in everyday clinical practice. We explore the spectrum of such T2 hypointense tumors and tumor mimickers that can arise from (1) the bones, presenting as diffuse processes or focal lesions; (2) the joints including diffuse or focal synovial disorders, loose bodies, or substance depositions; and (3) soft tissues, comprising T2 hypointense tumors and tumor mimickers (those that contain abundant fibrous tissue, mineralization, or hemosiderin deposits). Appropriate magnetic resonance imaging sequence selection is required to identify and characterize these lesions confidently when imaging musculoskeletal tumors.

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The diagnostic value of susceptibility-weighted imaging for identifying acute intraarticular hemorrhages

Milani

Daghighi

Mirza-Aghazadeh-Attari

et al. 2022

Skeletal Radiol

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Contribution of 3-T Susceptibility-Weighted MRI to Detection of Intraarticular Hemosiderin Accumulation in Patients With Hemophilia

Abstract: SWI contributes to more accurate grading of intraarticular hemosiderin accumulation than is achieved with conventional MRI sequences.

Cited by 6 publications

References 24 publications

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

T2-weighted Hypointense Tumors and Tumor-like Lesions

The diagnostic value of susceptibility-weighted imaging for identifying acute intraarticular hemorrhages

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