Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study

Bersch-Ferreira, Ângela Cristine; Sampaio, Geni Rodrigues; Gehringer, Marcella Omena; Torres, Elizabeth Aparecida Ferraz da Silva; Ross-Fernandes, Maria Beatriz; Silva, Jacqueline Tereza da; Torreglosa, Camila Ragne; Kovacs, Cristiane; Alves, Renata; Magnoni, Carlos Daniel; Weber, Bernardete; Rogero, Marcelo Macedo

doi:10.1186/s12937-018-0342-1

Cited by 32 publications

(27 citation statements)

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“…Our results are consistent with the expected action of increased n-3 in the reduction of IL-6 and liver weight in groups LO and SLO, which ingested higher levels of n-3 PUFA (p < 0.05) [50]. The increase in IL-10 in the LO group enhanced the protective characteristic of n-3 PUFA since it inhibited the production of IL-6, thereby reducing the pro-inflammatory effects [46,47].…”

Section: Discussionsupporting

confidence: 90%

“…The hypercholesterolemic index represents the proportion between PUFAs and SFA present in the diet and high values indicate a favorable nutritional balance; thus, the lower the SFA quantities, the lower the tendency to activate inflammatory markers, the risk of cardiovascular diseases, and the accumulation of free FAs in the liver [45,46]. The HH values of 4.82 for SO and 14.85 for LO are superior to those reported for Brazilian fish (1.87-2.18), already considered rather high [47].…”

Section: Discussionmentioning

confidence: 99%

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Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

et al. 2019

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Consumption of omega-3 (n-3) polyunsaturated fatty acids (PUFA) is related to improvement in the inflammatory response associated with decreases in metabolic disorders of obesity, such as low-grade inflammation and hepatic steatosis. Linseed (Linum usitatissimum) oil is a primary source of n-3 fatty acids (FAs) of plant origin, particularly α-linolenic acid, and provides an alternative for the ingestion of n-3 PUFA by persons allergic to, or wishing to avoid, animal sources. In our study, we evaluated the effect of the consumption of different lipidic sources on metabolic and inflammatory parameters in Wistar rats. We split 56 male rats into four groups that were fed for 60 days with the following diets: sesame oil, (SO, Sesamum indicum), linseed oil (LO), SO + LO (SLO), and a control group (CG) fed with animal fat. Our results reveal that the use of LO or SLO produced improvements in the hepatic tissue, such as lower values of aspartate aminotransferase, liver weight, and hepatic steatosis. LO and SLO reduced the weight of visceral fats, weight gain, and mediated the inflammation through a decrease in interleukin (IL)-6 and increase in IL-10. Though we did not detect any significant differences in the intestine histology and the purinergic system enzymes, the consumption of α-linolenic acid appears to contribute to the inflammatory and hepatic modulation of animals compared with a diet rich in saturated FAs and or unbalanced in n-6/n-3 PUFAs, inferring possible use in treatment of metabolic disorders associated with obesity and cardiovascular diseases.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

et al. 2019

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“…The tested dosages of CO did not demonstrate a protective effect on those parameters when compared with the group supplemented with soybean oil (CG) and both doses of olive oil (OO1; OO2). The cytokine IL-10 is necessary to inhibit the synthesis of proinflammatory cytokines [ 56 ]. It can exert anti-inflammatory effects through signal transducer pathway of the Janus kinase (JAK) of activation 3 (JAK-STAT3), binding IL-10 to the receptor in the targeted cell membrane—tyrosine kinase 2—leading to the activation of the signal transducer and activator of transcription 3 (STAT3).…”

Section: Resultsmentioning

confidence: 99%

Caryocar brasiliense Cambess. Pulp Oil Supplementation Reduces Total Cholesterol, LDL-c, and Non-HDL-c in Animals

et al. 2020

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The fruit of Caryocar brasiliense Cambess. is a source of oil with active compounds that are protective to the organism. In our work, we analyzed the physicochemical characteristics and evaluated the effects of supplementation with C. brasiliense oil in an animal model. We characterized the oil by indices of quality and identity, optical techniques of absorption spectroscopy in the UV–Vis region and fluorescence, and thermogravimetry/derived thermogravimetry (TG/DTG). For the animal experiment, we utilized mice (Mus musculus) supplemented with lipidic source in different dosages. The results demonstrated that C. brasiliense oil is an alternative source for human consumption and presents excellent oxidative stability. Primarily, it exhibited oleic MFA (53.56%) and palmitic SFA (37.78%). The oil level of tocopherols and tocotrienols was superior to the carotenoids. The supplementation with C. brasiliense oil reduced the levels of total cholesterol, LDL-c, and non-HDL-c. Regarding visceral fats and adiposity index, the treatment synergically supplemented with olive oil and C. brasiliense oil (OO + CO) obtained the best result. Therefore, C. brasiliense oil is a high quality product for consumption. Its supplementation promotes beneficial effects mainly on the lipidic profile.

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“…Insulin resistance is the central link of metabolic syndrome, and hsCRP concentration has been shown to be closely related to insulin resistance. It has been reported that serum hsCRP level of patients with cardiovascular disease combined with insulin resistance is higher than that of patients without insulin resistance, and it is positively correlated with saturated fatty acids and negatively correlated with unsaturated fatty acids [26]. Patients with high hsCRP level have more thin fibrous caps detected by optical correlation tomography (OCT), suggesting that hsCRP can reflect the instability of coronary plaque [27].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of high-risk coronary plaques in patients with and without metabolic syndrome and the relationship with prognosis

Luo

Han

et al. 2020

BMC Cardiovasc Disord

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Background: Metabolic syndrome (MS) is a disorder, characterized by clusters of cardiovascular risk factors such as central obesity, insulin resistance, dyslipidemia and hypertension. Patients with MS may have a higher plaque burden that increases their risk of major adverse cardiovascular events (MACEs). This study aimed to analyze the prevalence of high-risk coronary plaques in patients with and without MS by coronary computed tomography angiography (CCTA) and to investigate the relationship between MS, high-risk coronary plaques, and their prognosis. Methods: This was a retrospective cohort study of 1136 patients who underwent CCTA due to chest pain without obstructive heart disease (≥50% coronary stenosis) between January 2014 and December 2015 in our hospital. The relationships between high risk coronary plaques, MS, and other clinical factors were assessed. Multicollinearity analysis was performed to identify the collinearity between the variables. The proportional hazard assumption was checked and using Schoenfeld residual test. Cox proportional hazards model and Kaplan-Meier survival analysis assessed the relationship between MS, high-risk coronary plaques and MACEs.Results: High-risk plaques were more frequent in the MS group than non-MS group (P = 0.004). MS (HR = 2.128, 95%CI: 1.524-2.970, P < 0.001), presence of high-risk plaques (HR = 11.059, 95%CI: 7.749-57.232, P < 0.001) and high sensitivity C-reactive protein (hsCRP) (HR = 1.629, 95%CI: 1.128-2.352, P = 0.009) were related with an increased risk of MACEs in patients with risk factors for coronary heart disease. In patients with high-risk plaques, MS (HR = 2.265, 95%CI: 1.629-3.150, P < 0.001) and hsCRP (HR = 1.267, 95%CI: 1.191-1.348, P = 0.004) were related with an increased risk of MACEs. Kaplan-Meier analysis showed differences in MACEs between the MS and non-MS groups in the whole population and those with high-risk plaques (both P < 0.0001).Conclusions: High-risk plaques were more common in patients with MS. MS and the presence of high-risk plaques were independent risk factors for MACEs.

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Association between plasma fatty acids and inflammatory markers in patients with and without insulin resistance and in secondary prevention of cardiovascular disease, a cross-sectional study

Cited by 32 publications

References 50 publications

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

Protective Effect of α-Linolenic Acid on Non-Alcoholic Hepatic Steatosis and Interleukin-6 and -10 in Wistar Rats

Caryocar brasiliense Cambess. Pulp Oil Supplementation Reduces Total Cholesterol, LDL-c, and Non-HDL-c in Animals

Prevalence of high-risk coronary plaques in patients with and without metabolic syndrome and the relationship with prognosis

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