Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma

Martínez-Rivera, Vanessa; Negrete-García, María Cristina; Ávila‐Moreno, Federico; Ortiz‐Quintero, Blanca

doi:10.3390/ijms19020595

Cited by 26 publications

(30 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In lung cancer, neuroendocrine features, which are associated with an aggressive clinical course, were linked with miR‐375, 15 indicating a relationship between histopathology and miR expression. In MM, the expression profile and prognostic and diagnostic significance of miR have been reported; however, the significance of miR was not concordant, most likely due to the variety of approaches, techniques and collected samples 16,17 . In this study, we identified high expression of miR‐199/214 in SM with an miR microarray.…”

Section: Introductionmentioning

confidence: 69%

Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats

et al. 2020

View full text Add to dashboard Cite

Malignant mesothelioma (MM) is one of the most lethal tumors in humans. The onset of MM is linked to exposure to asbestos, which generates reactive oxygen species (ROS). ROS are believed to be derived from the frustrated phagocytosis and the iron in asbestos. To explore the pathogenesis of MM, peritoneal MM was induced in rats by the repeated intraperitoneal injection of iron saccharate and nitrilotriacetate. In the present study, we used microarray techniques to screen the microRNA (miR) expression profiles of these MM. We observed that the histological subtype impacted the hierarchical clustering of miR expression profiles and determined that miR‐199/214 is a distinctive feature of iron saccharate‐induced sarcomatoid mesothelioma (SM). Twist1, a transcriptional regulator of the epithelial‐mesenchymal transition, has been shown to activate miR‐199/214 transcription; thus, the expression level of Twist1 was examined in iron‐induced and asbestos‐induced mesotheliomas in rats. Twist1 was exclusively expressed in iron saccharate‐induced SM but not in the epithelioid subtype. The Twist1‐miR‐199/214 axis is activated in iron saccharate‐induced and asbestos‐induced SM. The expression levels of miR‐214 and Twist1 were correlated in an asbestos‐induced MM cell line, suggesting that the Twist1‐miR‐199/214 axis is preserved. MeT5A, an immortalized human mesothelial cell line, was used for the functional analysis of miR. The overexpression of miR‐199/214 promoted cellular proliferation, mobility and phosphorylation of Akt and ERK in MeT5A cells. These results indicate that miR‐199/214 may affect the aggressive biological behavior of SM.

show abstract

Section: Introductionmentioning

confidence: 69%

Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The definite diagnosis of mesothelioma is often challenging and complex, and the qualitative analysis of markers in pleural tissue via immunohistochemical test is the gold standard. Therefore, miRNAs and their molecular mechanisms that are associated with mesothelioma development could be potential diagnostic markers in mesothelioma [144]. Guled et al conducted the first study aimed at assessing the expression of miRNAs in mesothelioma.…”

Section: Mir-144 In Mesotheliomamentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

View full text Add to dashboard Cite

MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

show abstract

“…Whilst the only well‐founded current routinely available molecular technique for mesothelioma diagnosis is FISH for p16 deletion (and this is referred to briefly in the guideline), there are many other techniques that are evolving and which may become more widely available in the future. These include microRNA expression and DNA methylation in tissue or in circulating tumour cells/circulating tumour DNA . Any update of the guidelines will need to introduce these and discuss any potential role they may have now, or promise they might have for the future.…”

Section: Discussionmentioning

confidence: 99%

Guidelines for the cytopathologic diagnosis of epithelioid and mixed‐type malignant mesothelioma: Complementary statement from the international mesothelioma interest group, also endorsed by the international academy of cytology and the papanicolaou society of cytopathology. A proposal to be applauded and promoted but which requires updating

Sheaff

2020

Diagnostic Cytopathology

View full text Add to dashboard Cite

The guidelines for the cytopathologic diagnosis of epithelioid and mixed‐type malignant mesothelioma produced by the International Mesothelioma Interest Group and which are endorsed by the International Academy of Cytology and the Papanicolaou Society of Cytopathology are reviewed and discussed. This (predominantly) evidence‐based document provides a robust and useful framework for diagnosticians and guideline producers to emphasise and promote the value, power and role of cytology in mesothelioma diagnosis and management with comments and suggestions about how the guidelines can be updated and improved in the future.

show abstract

Secreted and Tissue miRNAs as Diagnosis Biomarkers of Malignant Pleural Mesothelioma

Cited by 26 publications

References 100 publications

Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats

Overexpression of miR‐199/214 is a distinctive feature of iron‐induced and asbestos‐induced sarcomatoid mesothelioma in rats

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Contact Info

Product

Resources

About