Eugenia brasiliensis leaves extract attenuates visceral and somatic inflammatory pain in mice

Simões, Róli Rodrigues; Kraus, Scheila Iria; Coelho, Igor S.; Dal-Secco, Daniela; Siebert, Diogo Alexandre; Micke, Gustavo Amadeu; Alberton, Michele Debiasi; Santos, Adair R.S.

doi:10.1016/j.jep.2018.02.026

Cited by 18 publications

(8 citation statements)

References 42 publications

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“…It has been reported that about 33% of the elderly over the age of 60 in China suffer from chronic pain [22, 23]. Currently, nonsteroidal anti-inflammatory drugs (NSAIDs), antidepressants, opioid analgesics, and antiepileptic drugs are mainly used in clinical treatment of chronic pain [24]. However, their treatment effect is limited and the treatment period is long.…”

Section: Discussionmentioning

confidence: 99%

Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Lin

Chen

Zeng

et al. 2022

Neuroimmunomodulation

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Background: Inflammatory pain mediated by nuclear factor kappa-B (NF-κB) signal pathway has become an increasingly important clinical issue in the last decade. As a potent antioxidant, Nodakenetin has been shown to have a prominent inhibitory effect on inflammation. However, the therapeutic effects and underlying pharmacological mechanisms of Nodakenetin for inflammatory pain remain unclear. Methods: Intraplanar injection of complete Freund’s adjuvant (CFA) was used to establish a model of chronic inflammation pain in C57BL/6 mice. The chronic neuropathic pain model was conducted by the sciatic nerve ligation surgery. QRT-PCR was performed to estimate the RNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Western blot was used to demonstrated the protein levels of phospho-IkappaBα (IκBα), p50, and p65 in HEK293T cells. Results: The bioactive components of the traditional Chinese medicine Notopterygium forbesii boiss mainly include Nodakenetin, isoimperatorin, and pregnenolone. Nodakenetin significantly alleviated CFA-induced inflammatory pain but showed no significant therapeutic effect on surgically induced neuralgia in a mouse model. In contrast, isoimperatorin and pregnenolone did not relieve CFA-induced inflammatory pain. Mechanistically, Nodakenetin inhibited IL-1β-induced activation of the NF-κB pathway and phosphorylation of IκBα in HEK293T cells. Furthermore, Nodakenetin treatment suppressed the expression of IL-6, TNF-α, and IL-1β in mouse bone marrow-derived macrophages. Conclusion: Nodakenetin alleviates inflammatory pain induced by CFA injection in vivo and modulates NF-κB signal pathway in vitro.

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Section: Discussionmentioning

confidence: 99%

Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Lin

Chen

Zeng

et al. 2022

Neuroimmunomodulation

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“…As the species Eugenia brasiliensis that is frequently found in the Atlantic Forest, in the south and southeast regions of Brazil and its varieties present great resources of bioactive compounds, especially when it comes to phenolic and carotenoid compounds (Simões et al, 2018;Araújo et al, 2019). Another important aspect to be highlighted is the fact that some studies suggest that the extract of E. brasiliensis can be considered an alternative for the treatment of chronic obstructive pulmonary diseases and also performs an antidepressant function in serotonergic, noradrenergic and dopaminergic systems, thus producing an implication similar to conventional treatment (Colla et al, 2012).…”

Section: Biological Activity Of Essential Oils In a Health Contextmentioning

confidence: 99%

Herbal oils in healthcare: a review

Silva

Dotto²

2022

Braz. J. of Sci.

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The herbal medicine market has grown considerably as an alternative currently used for the application of plants in the treatment of various diseases. In this environment, studies on the bioactivity of essential oils and the search for those that have antimicrobial, analgesic, anti-inflammatory, anti-tumor, antioxidant properties and also oils that can inhibit key enzymes are highlighted. However, research on the use of plants in the pharmaceutical industry, chemical composition of native species and possible biological activities are still scarce. Therefore, studies for the knowledge of native species with therapeutic potential gain great relevance. This study carried out a review of the research already done on essential oils from species with potentially promising biological activities for the contribution of the sustainable use of biodiversity and the relevance of their medicinal potential.

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“…The interest in these leaves concerns their high content of biologically active compounds [2,3], mainly flavonoids, such as catechin, myricetin, isoquercetin, rutin, quercetin, galangin, and apigenina [4,5]. Among the benefits conferred to the bioactive compounds from EBL leaves have already been described: antioxidant and antilipemic activity [6], anti-inflammatory [7], and antidepressant [8], as well as have been reported antifungal [9] and antibacterial activity [10].…”

Section: Introductionmentioning

confidence: 99%

“…The bioactives' profile on the EBL extracts results from the employed extraction method, the solidliquid extraction (SLE) techniques preferred due to their low cost and simple operation [17]. Besides being readily removed, water and ethanol stand out as low-cost and biocompatible solvents [7,18].…”

Section: Introductionmentioning

confidence: 99%

Natural Extracts from Eugenia brasiliensis Lam Leaves to Improve the Shelf-Life of Fresh Tomatoes

Souza

Toci²,

Mafra³

et al. 2022

Waste Biomass Valor

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In this work, hydroalcoholic extracts were obtained from leaves of Eugenia brasiliensis to be evaluated for the content of bioactive compounds and applied to fresh tomatoes for preservation. Analyzes of total phenolics, flavonoids, antioxidant and antibacterial activity, and toxicity were performed. Tomatoes were treated with the extracts by immersion in an aqueous solution at 200, 600, and 1000 mg/L and evaluated for 28 days for total soluble solids, titratable acidity, maturation index ascorbic acid content, weight loss, and visual test. The presence of gallic acid, rutin, and quercetin was identified in all extracts. The extracts obtained by water and ethanol at 25% e 50% showed better results regarding phenolic compounds; antioxidant and antimicrobial activity. However, the 25 and 50% ethanol extracts were the only ones that showed toxicity. The treatments proposed for the conservation of tomatoes, in concentrations superior to 600 mg/L, showed promising results, mainly in the protection of the fruits regarding the loss of water and, consequently, visual depreciation due to the appearance of wrinkles. Thus, most proposed treatments demonstrated viability because of conserving organoleptic properties of fresh tomatoes.

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Eugenia brasiliensis leaves extract attenuates visceral and somatic inflammatory pain in mice

Cited by 18 publications

References 42 publications

Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Nodakenetin Alleviates Inflammatory Pain Hypersensitivity by Suppressing NF-κB Signal Pathway

Herbal oils in healthcare: a review

Natural Extracts from Eugenia brasiliensis Lam Leaves to Improve the Shelf-Life of Fresh Tomatoes

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