Current status of drug vial optimization use to prevent waste associated with injectable anticancer agents

Suzuki, Shinya; Gilbar, Peter J; Yu, Bo; Matsuyama, Chihiro; Yamaguchi, Masakazu

doi:10.1177/1078155218758501

Cited by 8 publications

(6 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While medical institutions using intelligent dispensing robots for drug preparation will still charge patients for preparations, the cost will be much less than the expenses on wasted drug; so if this aspect is applied to the actual process, then patients, medical institutions, and national health insurance agencies will all benefit. Additionally, it will reduce the risk of exposing medications to healthcare workers during the process of chemotherapy drug dispensing ( 19 ) as well as the cost of disposing of waste fluids in healthcare facilities ( 17 ). To implement the vial-sharing strategy more effectively, we need to get the support of professional pharmacy organizations and government bodies.…”

Section: Discussionmentioning

confidence: 99%

Cost analysis of implementing a vial-sharing strategy for chemotherapy drugs using intelligent dispensing robots in a tertiary Chinese hospital in Sichuan

Liu

Zou

Song

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

IntroductionChemotherapy drug wasting is a huge problem in oncology that not only results in excessive expenses on chemotherapy drugs but also increases the cost of disposing of chemotherapy waste and the risk of occupational exposure in the environment. The main objective of this study was to evaluate the potential for hospitals in China to employ a real-time vial-sharing strategy that can save drug costs.MethodThis study was conducted retrospectively at Pharmacy Intravenous Admixture Services (PIVAS), People's Hospital of Sichuan Province, China, from September to November 2021. Data on prescription drugs wasted were collected from the Hospital Information System (HIS). To assess the real-time vial-sharing strategy, we estimated drug wastage and drug waste costs using intelligent robots that dispense multiple prescriptions simultaneously.Results24 of the 46 wasted drugs were cost-saved. The vial-sharing strategy saved 186,067 mg of drugs, or ~59.08% of the total amount wasted, resulting in savings of 150,073.53 China Yuan (CNY), or 47.51% of the cost of the total waste.ConclusionOur investigation established that employing a real-time vial-sharing strategy using an intelligent robot to dispense multiple prescriptions simultaneously is cost-effective. Additionally, this approach presented no safety issue concerns, such as the introduction of impurities to sterile compounding via repeated interspersing or the incorrect registration of information during drug storage, often encountered with traditional vial-sharing strategies.

show abstract

Section: Discussionmentioning

confidence: 99%

Cost analysis of implementing a vial-sharing strategy for chemotherapy drugs using intelligent dispensing robots in a tertiary Chinese hospital in Sichuan

Liu

Zou

Song

et al. 2022

Front. Public Health

View full text Add to dashboard Cite

show abstract

“…Furthermore, until the release of the Guidance on Safe Multiple Use of Injectable Anticancer Drugs in 2018, it was mandated that vials should be punctured, used once, and quickly discarded. Large-dose products were introduced earlier in Europe and the United States than in Japan based on the premise of DVO [ 6 ]. The use of large-dose products is particularly economical for general-purpose products, and the development of an environment in Japan in which such products can be used will also be useful in reducing costs [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Japan and other countries, reducing unnecessary costs associated with the disposal of anticancer drugs is a key factor in the optimization of medical resources. By contrast, many Western countries, including the United States, have implemented DVO to increase the efficiency of anticancer treatment, resulting in decreases in the total drug costs [ 6 – 9 ]. However, because of the aforementioned reasons, there has been little progress in reducing drug waste in Japan.…”

Section: Introductionmentioning

confidence: 99%

Estimating the effect of optimizing anticancer drug vials on medical costs in Japan based on the data from a cancer hospital

Matsuo

Nomura

Uchiyama

et al. 2020

BMC Health Serv Res

View full text Add to dashboard Cite

Background The substantial increase in the use of expensive anticancer drugs has been accompanied by an increase in the amount of disposing residual liquid from drug preparations. Many Western countries, including the United States, have implemented drug vial optimization (DVO) to prevent the waste of anticancer drugs and have reported the reductions in the total drug costs. This study was designed to estimate the expected reduction in spending on anticancer drugs by Japanese cancer hospitals when DVO was implemented instead of individual preparations and to test the effectiveness of this approach. Methods We investigated the doses of drugs used and quantity specifications for individually prepared vials for patients who received anticancer drug treatment in December 2017 at the Outpatient Treatment Center of the National Cancer Center Hospital East. Based on these findings, we calculated the total quantity of each drug used on a given day, and the minimum cost for preparation of the number of specified combinations corresponding to the total cost (DVO preparation). Based on the differences in these two costs, we estimated the economic impact of implementing DVO. Results While the cost for anticancer drugs for the 1-month study period was US$3,305,595 (US$1 = \110) for individual preparations, the estimated cost for DVO preparations was US$3,092,955, equivalent to a reduction of US$212,640. Conclusions Based on these study results, implementation of DVO-based preparation of injectable anticancer drugs in Japan in 2017 would have resulted in saving approximately US$460 million. This calculation revealed the need for the Japanese government to modify the methods employed to calculate drug costs in the insurance system and develop policies for the proper and optimal use of medical resources.

show abstract

“…Different strategies have been adopted over the years and have involved the centralization, the grouping of patients by therapeutic protocol, the appropriate selection of drug dosages, the use of closed-system transfer device (CSTD) and dose rounding. [12][13][14] A previous study found that 6.1% of the annual cytostatic drug budget was wasted during the chemotherapy compounding process. This study assessed the practice of centralization and did not take into account the possibility of extending the microbiological stability of anticancer drugs.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer drug waste minimization and cost-saving study by using a closed-system transfer device for chemotherapy compounding

Adade

Diop

Attjioui

et al. 2021

J Oncol Pharm Pract

View full text Add to dashboard Cite

Introduction There is a need for an economic evaluation of the use of closed system (CSTD) in chemotherapy compounding, especially in resource-constrained settings. Objective The objective of this study was to assess the cost saving of the management of cancer drug leftovers before and after introduction of CSTD associated with an extension of the beyond-use date (BUD) of cancer vials. A secondary objective was to estimate the level of minimization of drug wastage. Materials and methods This was a prospective, single-center study with two periods of two months each. The cost of drugs saved by using conventional systems (syringe and needle) without a closed system in the first period was compared to the cost of drugs saved by using the CSTD Chemoclave® system in the second period. The drug waste minimization rate compared actual drug waste to potential waste in Period 2. Results In Period 1, the amount of drug saved accounted for an average of 10.3% of the amount used in milligrams and the amount of drug wasted accounted for an average of 18.7%. In period 2, these proportions were 15.2% and 6.4% respectively. The CSTD generated an extra cost of 11,962.5 USD compared to the conventional system. The drug saved cost related only to the CSTD and the acquisition cost of the CSTD was a deficit of -7,444.95 USD and the cost saved from the compounding (CSTD and syringes) was a gain of 1,722.01 USD. The waste minimization represented an average of 72.5% ± 24.4% of potential waste. Conclusion The use of CSTD to extend the BUD allowed to reduce waste due to microbiological instability without adding an economic profit.

show abstract

Current status of drug vial optimization use to prevent waste associated with injectable anticancer agents

Cited by 8 publications

References 9 publications

Cost analysis of implementing a vial-sharing strategy for chemotherapy drugs using intelligent dispensing robots in a tertiary Chinese hospital in Sichuan

Cost analysis of implementing a vial-sharing strategy for chemotherapy drugs using intelligent dispensing robots in a tertiary Chinese hospital in Sichuan

Estimating the effect of optimizing anticancer drug vials on medical costs in Japan based on the data from a cancer hospital

Anticancer drug waste minimization and cost-saving study by using a closed-system transfer device for chemotherapy compounding

Contact Info

Product

Resources

About