How to Measure Tissue Oxygenation Using Near-Infrared Spectroscopy in a Patient With Alkaptonuria

Kovač, Petra; Miš, Katarina; Pirkmajer, Sergej; Marš, Tomaž; Klokočovnik, Tomislav; Kotnik, Gloria; Podbregar, Eva; Podbregar, Matej

doi:10.1053/j.jvca.2018.01.020

Cited by 4 publications

(7 citation statements)

References 10 publications

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“…However, other rSO 2 , like kidney, are tested to give additional value to brain rSO 2 during resuscitation in pediatric population [ 27 , 28 ]. Monitoring of skeletal muscle rSO 2 seem to be technically more reliably compared to brain rSO 2 , especially due to brain location in the body [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

“…We have previously shown that skeletal muscle rSO 2 can predict adequacy of flow (i.e., mixed venous oxygenation) in patients with shock with preserved oxygen extraction; it can also be used to track effects of therapy [ 8 , 18 ]. Despite new NIRS technologies and design of probes, skeletal muscle rSO 2 monitoring remains technically more reliably compared to brain rSO 2 , because skeletal muscle is covered with a thin layer of skin and subcutis compared to brain, which is hidden in the skull and floating in the cerebrospinal fluid [ 19 ]. A short paper already reported an illustrative case series of skeletal muscle rSO 2 use in five patients in the emergency department, showing fast response of skeletal muscle rSO 2 value to loss or return of pulse [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

Košir,

Možina,

Podbregar

2023

Eur J Med Res

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Background Near-infrared spectroscopy (NIRS) provides regional tissue oxygenation (rSO2) even in pulseless states, such as out-of-hospital cardiac arrest (OHCA). Brain rSO2 seems to be important predictor of return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR). Aim of our study was to explore feasibility for monitoring and detecting changes of skeletal muscle rSO2 during resuscitation. Methods Skeletal muscle and brain rSO2 were measured by NIRS (SenSmart Model X-100, Nonin, USA) during CPR in adult patient with OHCA. Start (basal) rSO2, maximal during CPR (maximal) and difference between maximal–minimal rSO2 (delta-rSO2), were recorded. Patients were divided into ROSC and NO-ROSC group. Results 20 patients [age: 66.0ys (60.5–79.5), 65% male] with OHCA [50% witnessed, 70% BLS, time to ALS 13.5 min (11.0–19.0)] were finally analyzed. ROSC was confirmed in 5 (25%) patients. Basal and maximal skeletal muscle rSO2 were higher in ROSC compared to NO-ROSC group [49.0% (39.7–53.7) vs. 15.0% (12.0–25.2), P = 0.006; 76.0% (52.7–80.5) vs. 34.0% (18.0–49.5), P = 0.005, respectively]. There was non-linear cubic relationship between time of collapse and basal skeletal muscle rSO2 in witnessed OHCA and without BLS (F-ratio = 9.7713, P = 0.0261). There was correlation between maximal skeletal muscle and brain rSO2 (n = 18, rho: 0.578, P = 0.0121). Conclusions Recording of skeletal muscle rSO2 during CPR in patients with OHCA is feasible. Basal and maximal skeletal muscle rSO2 were higher in ROSC compared to NO-ROSC group. Clinical trial registration number ClinicalTrials.gov, NCT04058925, registered on: 16th August 2019. URL of trial registry record: https://www.clinicaltrials.gov/ct2/show/NCT04058925?titles=Tissue+Oxygenation+During+Cardiopulmonary+Resuscitation+as+a+Predictor+of+Return+of+Spontaneous+Circulation&draw=2&rank=1.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

Košir,

Možina,

Podbregar

2023

Eur J Med Res

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“…Skeletal muscle is covered with a thin layer of skin and subcutis compared to brain, which is hidden in the skull and oating in the liquor. (19) Several NIRS devices are available for clinical use. They differ according to numerous aspects, which include the algorithms adopted, the type of light source, the wavelengths of light emitted, the number and distance between the light emitters and detectors.…”

Section: Discussionmentioning

confidence: 99%

“…(27,28) We have previously shown high grade diversity of brain rSO 2 , with different NIRS devices, in patients with alkaptonuria. (19,29) Widespread tissue deposition of black pigment known as tissue ochronosis, has been described in autopsy ndings of alkaptonuric patients. (30) (34) This may be due to the NIRS method, which does not discriminate between compartments.…”

Section: Discussionmentioning

confidence: 99%

Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

Košir

Možina

Podbregar

2022

Preprint

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BackgroundNear-infrared spectroscopy (NIRS) provides regional tissue oxygenation (rSO2) even in pulseless states such as out-of-hospital cardiac arrest (OHCA). Brain rSO2 seems to be important predictor of return of spontaneous circulation (ROSC) during cardiopulmonary resuscitation (CPR). Aim of our study was to explore feasibility for monitoring and detecting changes of skeletal muscle rSO2 during resuscitation.MethodsSkeletal muscle and brain rSO2 were measured by NIRS (SenSmart Model X-100, Nonin, USA) during CPR in adult patient with OHCA. Start (basal) rSO2, maximal during CPR (maximal), difference between maximal-minimal rSO2 (delta-rSO2), and at the end of CPR (end-CPR rSO2) were recorded. Patients were divided into ROSC and NO-ROSC group.Results20 patients (age: 66.0ys (60.5–79.5), 65% male) with OHCA (50% witnessed, 70% BLS, time to ALS 13.5min (11.0–19.0)) were finally analyzed. 10 patients were excluded due to violation of protocol or technical difficulties. ROSC was confirmed in 5 (25%) patients. Basal, maximal and end-CPR skeletal muscle rSO2 were higher in ROSC compared to NO-ROSC group (49.0% (39.7–53.7) vs. 15.0% (12.0-25.2), p = 0.006; 76.0% (52.7–80.5) vs. 34.0% (18.0-49.5), p = 0.005; 72.0% (48.7–74.7) vs. 16.0% (12.0–35.0), p = 0.002, respectively). There was weak relationship between time of collapse and basal skeletal muscle rSO2 in witnessed OHCA (n = 7, rho: -0.750, p = 0.0522). There was correlation between maximal skeletal muscle and brain rSO2(n = 18, rho: 0.578, P = 0.0121).ConclusionsRecording of skeletal muscle rSO2 during CPR in patients with OHCA is feasible. Basal, maximal and end-CPR skeletal muscle rSO2 were higher in ROSC compared to NO-ROSC group.Clinical trial registration number:ClinicalTrials.gov, NCT04058925, registered on: 16th August 2019. URL of trial registry record: https://www.clinicaltrials.gov/ct2/show/NCT04058925?titles=Tissue+Oxygenation+During+Cardiopulmonary+Resuscitation+as+a+Predictor+of+Return+of+Spontaneous+Circulation&draw=2&rank=1

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“…To obtain additional information about the oxygen state of tissues and the processes occurring in the studied microvasculature, we developed a multichannel system that operates in a wide range of optical radiation from 410 to 940 nm. Currently used research instruments operate the optical range from 600 to 960 nm [ 44 , 45 , 46 , 47 ]. The same wavelengths λ are needed to compare the results.…”

Section: Methodsmentioning

confidence: 99%

New Methodology of Human Health Express Diagnostics Based on Pulse Wave Measurements and Occlusion Test

Davydov

Zaitceva

Давыдов

et al. 2023

JPM

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Nowadays, with the increase in the rhythm of life, the relevance of using express diagnostics methods for human health state estimation has significantly increased. We present a new express diagnostics method based on non-invasive measurements (the pulse wave shape, heart rate, blood pressure, and oxygen saturation of blood vessels and tissues). A feature of these measurements is that they can be carried out both in the hospital and at home. The new compact and portable optical hardware–software complex has been developed to measure tissue oxygen saturation. This complex makes it possible to reduce the measurement time from 60 min to 7–8 min, which reduces the likelihood of artifacts in the measurement process and increases its reliability. A new technique has been developed to carry out these measurements. A new optical sensor based on a line of charge-coupled devices has been developed to register a pulse wave in the far peripheral zone. The developed new technique for processing the pulse waveform and data on the oxygen saturation of hemoglobin in the blood and tissues allows a person to obtain additional information about their state of health independently. It will help to make conclusions about taking the necessary measures. This additional information allows the attending physician to provide more effective control over the course of treatment of the patient at any time since the methods of express diagnostics proposed by us have no restrictions on the number of applications. The functional state of more than 300 patients was studied. The results of various measurements are presented.

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How to Measure Tissue Oxygenation Using Near-Infrared Spectroscopy in a Patient With Alkaptonuria

Cited by 4 publications

References 10 publications

Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

Skeletal muscle oxygenation during cardiopulmonary resuscitation as a predictor of return of spontaneous circulation: a pilot study

New Methodology of Human Health Express Diagnostics Based on Pulse Wave Measurements and Occlusion Test

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