Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity

Kwon, Soonbum; Lee, Yeongcheol; Jung, Young-Eun; Kim, Ju Hee; Baek, Byungyeob; Lim, Bumhee; Lee, Jung-Eun; Kim, Ikyon; Lee, Jeeyeon

doi:10.1016/j.ejmech.2018.02.016

Cited by 49 publications

(28 citation statements)

References 54 publications

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“…The label-free imaging using RI will also have potentials for the cytotoxicity assay (Kwon et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging

Kim

Lee

et al. 2017

Preprint

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Live cell imaging provides critical information in the investigation of cell biology and related pathophysiology. Refractive index (RI) can serve as intrinsic optical imaging contrast for 3-D label-free and quantitative live cell imaging, and provide invaluable information to understand various dynamics of cells and tissues for the study of numerous fields. Recently significant advances have been made in imaging methods and analysis approaches utilizing RI, which are now being transferred to biological and medical research fields, providing novel approaches to investigate the pathophysiology of cells. To provide insight how RI can be used as an imaging contrast for bioimaging, here we provide the basic principle of RI-based imaging techniques and summarize recent progress on applications, ranging from microbiology, hematology, infectious diseases, hematology, and histopathology.

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“…The label-free imaging using RI will also have potentials for the cytotoxicity assay (Kwon et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging

Kim

Lee

et al. 2017

Preprint

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“…ODT provides label-free and quantitative imaging of live cells and tissues without complicated sample preparation procedures [26]. ODT has been widely utilized for the study of biological samples, including microalgae [27], plant biology [28], membrane biophysics [29], immunology [30], infectious disease [31], and pharmacology [32].…”

Section: A Optical Diffraction Tomographymentioning

confidence: 99%

Generalized quantification of three-dimensional resolution in optical diffraction tomography using the projection of maximal spatial bandwidths

2018

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Optical diffraction tomography (ODT) is a three-dimensional (3D) quantitative phase imaging technique, which enables the reconstruction of the 3D refractive index (RI) distribution of a transparent sample. Due to its fast, noninvasive, and quantitative 3D imaging capability, ODT has emerged as one of the most powerful tools for various applications. However, the spatial resolution of ODT has only been quantified along the lateral and axial directions for limited conditions; it has not been investigated for arbitrary-oblique directions. In this paper, we systematically quantify the 3D spatial resolution of ODT by exploiting the spatial bandwidth of the reconstructed scattering potential. The 3D spatial resolution is calculated for various types of ODT systems, including the illumination-scanning, samplerotation, and hybrid scanning-rotation methods. In particular, using the calculated 3D spatial resolution, we provide the spatial resolution as well as the arbitrary sliced angle. Furthermore, to validate the present method, the point spread function of an ODT system is experimentally obtained using the deconvolution of a 3D RI distribution of a microsphere and is compared with the calculated resolution. The present method for defining spatial resolution in ODT is directly applicable for various 3D microscopic techniques, providing a solid criterion for the accessible finest 3D structures.

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“…Cancer is a major cause of death in populations all over the world. Despite being the current treatment of choice in many cases, chemotherapy still has many disadvantages, such as strong toxic side-effects and partial lack of targeting specificity [1][2][3]. Therefore, the design and synthesis of new compounds that act specifically on target proteins in tumor cells is a focus of current research [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway

Guo

Guan

et al. 2020

Molecules

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A series of amide anthraquinone derivatives, an important component of some traditional Chinese medicines, were structurally modified and the resulting antitumor activities were evaluated. The compounds showed potent anti-proliferative activities against eight human cancer cell lines, with no noticeable cytotoxicity towards normal cells. Among the candidate compounds, 1-nitro-2-acyl anthraquinone-leucine (8a) showed the greatest inhibition of HCT116 cell activity with an IC50 of 17.80 μg/mL. In addition, a correlation model was established in a three-dimensional quantitative structure-activity relationship (3D-QSAR) study using Comparative Molecular Field Analysis (CoMFA) and comparative molecular similarity index analysis (CoMSIA). Moreover, compound 8a effectively killed tumor cells by reactive oxygen species (ROS)-JNK activation, causing an increase in ROS levels, JNK phosphorylation, and mitochondrial stress. Cytochrome c was then released into cytoplasm, which, in turn activated the cysteine protease pathway and ultimately induced tumor cell apoptosis, suggesting a potential use of this compound for colon cancer treatment.

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Mitochondria-targeting indolizino[3,2-c]quinolines as novel class of photosensitizers for photodynamic anticancer activity

Cited by 49 publications

References 54 publications

Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging

Holotomography: refractive index as an intrinsic imaging contrast for 3-D label-free live cell imaging

Generalized quantification of three-dimensional resolution in optical diffraction tomography using the projection of maximal spatial bandwidths

Novel Anthraquinone Compounds Inhibit Colon Cancer Cell Proliferation via the Reactive Oxygen Species/JNK Pathway

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