Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort

Pak, Linda M.; Chakraborty, Jayasree; Gönen, Mithat; Chapman, William C.; Gian, Richard Kinh; Koerkamp, Bas Groot; Verhoef, Kees; Lee, Ser Yee; Massani, Marco; Stok, Eric P. van der; Simpson, Amber L.; Jarnagin, William R.; Allen, Peter J.; D’Angelica, Michael I.; DeMatteo, Ronald P.; Kingham, T. Peter; Balachandran, Vinod P.

doi:10.1016/j.jamcollsurg.2018.02.001

Cited by 12 publications

(9 citation statements)

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“…Strict patient selection and precise assessment of the size and quality of the remnant liver are pivotal to the decision-making process[ 14 ]. Although experiences gained from previous studies have indicated that after extended hepatectomy involving 70% to 75% of the liver, the remnant liver can still function well in non-cirrhosis patients[ 15 , 16 ], the strategy may need to be adjusted in the application of ERLA. A major feature of endoscopic retrograde appendicitis treatment (ERAT) is the longer CIT compared with ordinary liver transplantation (LT)[ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Ex vivo liver resection followed by autotransplantation in radical resection of gastric cancer liver metastases: A case report

Wang¹,

Zhang²,

Ou³

et al. 2021

WJCC

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BACKGROUND Radical resection of gastric cancer liver metastases (GCLM) can increase the 5-year survival rate of GCLM patients. However, patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases. CASE SUMMARY A 29-year-old woman had a chief complaint of chronic abdominal pain for 1 year. Abdominal computed tomography and magnetic resonance imaging examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver. The anterior wall of the gastric antrum was unevenly thickened. The diagnosis of (gastric antrum) intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance. She underwent radical resection (excision of both gastric tumors and ex vivo liver resection followed by autotransplantation simultaneously) followed by XELOX adjuvant chemotherapy. Without serious postoperative complications, the patient was successfully discharged on the 20 th day after the operation. Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved. The resected mass was confirmed to be poorly differentiated gastric carcinoma (hepatoid adenocarcinoma with neuroendocrine differentiation) with liver metastases in segments VIII. No recurrence or metastasis within the liver was found during a 7.5-year follow-up review that began 1 mo after surgery. CONCLUSION Application of ex vivo liver resection followed by autotransplantation in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Ex vivo liver resection followed by autotransplantation in radical resection of gastric cancer liver metastases: A case report

Wang¹,

Zhang²,

Ou³

et al. 2021

WJCC

View full text Add to dashboard Cite

show abstract

“…Strict patient selection and precise assessment of the size and quality of the remnant liver are pivotal to the decision-making process (14). Although experiences gained from previous studies have indicated that after extended hepatectomy involving 70 to 75% of the liver, the remnant liver can still function well in non-cirrhosis patients (15,16), the strategy may need to be adjusted in the application of ERLA according to the speci c situation. A major feature of ERAT is the longer CIT compared with ordinary LT (17).…”

Section: Discussionmentioning

confidence: 99%

Application of Ex Vivo Liver Resection Followed by the Autotransplantation Technique in Radical Resection of Gastric Cancer Liver Metastases: A Case Report

Wang

Zhang

et al. 2020

Preprint

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Background Radical resection of gastric cancer liver metastases can increase the 5-year survival rate of GCLM patients. However, patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases. Case presentation A 29-year-old female had a chief complaint of chronic abdominal pain for one year. Abdominal CT and MRI examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver. The anterior wall of the gastric antrum was unevenly thickened. The diagnosis of (gastric antrum) intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance. The pathological properties of the liver mass remained unclear before surgery. She underwent radical resection (excision of both gastric tumors and ELRA simultaneously）followed by XELOX adjuvant chemotherapy. Without serious postoperative complications, the patient was successfully discharged on the 20th day after the operation. Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved. The resected mass was confirmed to be poorly differentiated gastric carcinoma (hepatoid adenocarcinoma with neuroendocrine differentiation) with liver metastases in segments 6 and 8. A Follow-up review that began one month after surgery showed no recurrence or metastasis within the liver. The mother of three children miraculously lived a happy life and went back to work as normal. Conclusions: Application of ELRA in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.

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“…Strict patient selection and precise assessment of the size and quality of the remnant liver are pivotal to the decision-making process (14). Although experiences gained from previous studies have indicated that after extended hepatectomy involving 70 to 75% of the liver, the remnant liver can still function well in non-cirrhosis patients (15,16), the strategy may need to be adjusted in the application of ERLA. A major feature of ERAT is the longer CIT compared with ordinary LT (17).…”

Section: Discussionmentioning

confidence: 99%

Application of Ex Vivo Liver Resection Followed by the Autotransplantation Technique in Radical Resection of Gastric Cancer Liver Metastases: A Case Report

Wang

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Radical resection of gastric cancer liver metastases can increase the 5-year survival rate of GCLM patients. However, patients may lose the theoretical feasibility of surgery due to the critical location of liver metastasis in some cases.Case presentation: A 29-year-old female had a chief complaint of chronic abdominal pain for one year. Abdominal CT and MRI examinations suggested a mass of unknown pathological nature located between the first and second hila and the margin of the lower segment of the right lobe of the liver. The anterior wall of the gastric antrum was unevenly thickened. The diagnosis of (gastric antrum) intramucosal well-differentiated adenocarcinoma was histopathologically confirmed by puncture biopsy with gastroscopy guidance. She underwent radical resection（excision of both gastric tumors and ELRA simultaneously）followed by XELOX adjuvant chemotherapy. Without serious postoperative complications, the patient was successfully discharged on the 20th day after the operation. Pathological examination of the excised specimen indicated that gastrectomy with D2 lymph node dissection for primary gastric tumors and R0 resection for liver metastases were achieved. The resected mass was confirmed to be poorly differentiated gastric carcinoma (hepatoid adenocarcinoma with neuroendocrine differentiation) with liver metastases in segments VIII. No recurrence or metastasis within the liver was found during a 7.5-year follow-up review that began one month after surgery.Conclusions: Application of ELRA in radical resection for GCLM can help selected patients with intrahepatic metastases located in complex sites obtain a favorable clinical outcome.

show abstract

Quantitative Imaging Features and Postoperative Hepatic Insufficiency: A Multi-Institutional Expanded Cohort

Abstract: Quantitative imaging features are independently associated with PHLI and are a promising preoperative risk stratification tool.

Cited by 12 publications

References 50 publications

Ex vivo liver resection followed by autotransplantation in radical resection of gastric cancer liver metastases: A case report

Ex vivo liver resection followed by autotransplantation in radical resection of gastric cancer liver metastases: A case report

Application of Ex Vivo Liver Resection Followed by the Autotransplantation Technique in Radical Resection of Gastric Cancer Liver Metastases: A Case Report

Application of Ex Vivo Liver Resection Followed by the Autotransplantation Technique in Radical Resection of Gastric Cancer Liver Metastases: A Case Report

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