Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence

Investigation of serum calcium and vitamin D levels in superior semicircular canal dehiscence syndrome: A case control study

“…Only one retrospective study was identified looking at bone metabolic markers in SSCD patients. Calcium level data were retrospectively available for 79 patients ( Nguyen et al., 2018 ). In that study, the level of calcium negatively correlated with the need for revision surgery.…”

“…This could be a result of osteoclastic activity in the bony labyrinth resulting in a dehiscence later in life. A study looking at the effect of calcium and vitamin D in SSCD subjects who underwent plugging, showed that the higher the calcium level the less likely the need for further corrective surgery but there was no mention of pre-operative calcium levels and the association with patients’ symptomatology ( Nguyen et al., 2018 ).…”

Superior semicircular canal dehiscence: a narrative review

“…47 Additionally, a recent study investigating bone metabolism markers concluded that such markers could be important in the clinical assessment and management of patients with superior semicircular canal dehiscence. 48…”

“…On the other hand, the prevalence of superior semicircular canal dehiscence has been found to be higher in older patients and in those with osteoporosis, suggesting an acquired rather than a congenital origin. 12,[47][48][49][50] For instance, an assessment of 306 temporal bone CT scans showed increased radiological prevalence in older patients, with nearly 8 per cent of the scans showing superior semicircular canal dehiscence and nearly 45 per cent showing thinning of the bony cover of the superior semicircular canal. 12 Two years later, using similar settings, a study involving temporal bone imaging of 312 patients showed slight osteopenia of the superior semicircular canal roof associated with ageing.…”

“…47 Additionally, a recent study investigating bone metabolism markers concluded that such markers could be important in the clinical assessment and management of patients with superior semicircular canal dehiscence. 48 Despite the abovementioned evidence, and the possibility of superior semicircular canal dehiscence being an acquired condition, the otic capsule undergoes little remodelling once its development is completed, mostly because of factors related to genetics of the inner ear. 51,52 Thus, the direct impact of bony changes of the temporal bone on the superior semicircular canal itself is debatable.…”