The Effect of Oligofructose-Enriched Inulin on Faecal Bacterial Counts and Microbiota-Associated Characteristics in Celiac Disease Children Following a Gluten-Free Diet: Results of a Randomized, Placebo-Controlled Trial

Abstract

Celiac disease (CD) is associated with intestinal microbiota alterations. The administration of prebiotics could be a promising method of restoring gut homeostasis in CD. The aim of this study was to evaluate the effect of prolonged oligofructose-enriched inulin (Synergy 1) administration on the characteristics and metabolism of intestinal microbiota in CD children following a gluten-free diet (GFD). Thirty-four paediatric CD patients (mean age 10 years; 62% females) on a GFD were randomized into two experimental groups receiving Synergy 1 (10 g/day) or placebo (maltodextrin; 7 g/day) for 3 months. The quantitative gut microbiota characteristics and short-chain fatty acids (SCFAs) concentration were analysed. In addition, side effects were monitored. Generally, the administration of Synergy 1 in a GFD did not cause any side effects. After the intervention period, Bifidobacterium count increased significantly (p < 0.05) in the Synergy 1 group. Moreover, an increase in faecal acetate and butyrate levels was observed in the prebiotic group. Consequently, total SCFA levels were 31% higher than at the baseline. The presented trial shows that Synergy 1 applied as a supplement of a GFD had a moderate effect on the qualitative characteristics of faecal microbiota, whereas it stimulated the bacterial metabolite production in CD children.

Beneficial Effect of Oligofructose-Enriched Inulin on Vitamin D and E Status in Children with Celiac Disease on a Long-Term Gluten-Free Diet: A Preliminary Randomized, Placebo-Controlled Nutritional Intervention Study

“…Prebiotics can stimulate short-chain fatty acid production by intestinal microbiota, which in turn facilitate gut epithelium functions [16]. An increase in short-chain fatty acid concentration after prebiotic intake in children with CD was confirmed in our previous study [17]. Of note, in this study, children of both experimental groups were consecutively supplemented with the stable dose of vitamin D before and during the intervention, but a significant increase in vitamin D level was observed only in the Synergy 1 group.…”

“…The main mode of action of prebiotics is facilitating the development and/or metabolic activity of selected microbiota in the gut [16,17]. In the present study, we aimed to check whether prebiotics can ameliorate the status of fat-soluble vitamins and minerals in patients with CD on a GFD.…”

Inulin and metformin ameliorate polycystic ovary syndrome <i>via</i> anti-inflammation and modulating gut microbiota in mice

“…Accumulating studies have demonstrated that inulin may increase proportions of Bifidobacterium and Lactobacillus [32,34]. Probiotic Bifidobacterium possessed capable of suppression of pro-inflammatory cytokine synthesis [35][36][37].…”

Metabolically healthy obese and metabolic syndrome of the lean: the importance of diet quality. Analysis of MAGNETIC cohort

“…For data-driven dietary pattern analysis (a posteriori approach), data was collected using validated for Polish population food frequency questionnaire (FFQ-6) [29]; the self-administered version of FFQ-6 was used. The questionnaire was previously used in various populations [30][31][32], with the reproducibility being recently described in detail elsewhere [29].…”