Effects of Pulsatile Blood Flow on Oxygenator Performance

Abstract

Extracorporeal membrane oxygenation (ECMO) is mainly used for the therapy of acute respiratory distress syndrome and chronic obstructive lung disease. In the last years, the development of these systems underwent huge steps in optimization, but there are still problems with thrombus formation, clogging, and thus insufficient gas exchange. One idea of ECMO optimization is a pulsatile blood flow through the oxygenator, but this is still a controversy discussion. Analyzing available publications, it was not possible to identify a general statement about the effect of pulsatile blood flow on the gas exchange performance. The variety of parameters and circuit components have such a high influence on the outcome that a direct comparison of the studies is difficult. For this reason, we performed a structured study to evaluate the effects of pulsatile blood flow on the gas exchange performance of oxygenator. In in vitro tests according to DIN EN ISO 7199, we tested a small oxygenator (0.25 m exchange surface, polymethylpentene fibers, 33 mL priming volume) with constant and pulsatile blood flow in comparison. Therefore, we varied the mean blood flow from 250 to 1200 mL/min, the amplitude of 0, 20, and 50%, and the frequency of 30, 60, and 90 bpm. The results demonstrate that the gas transfer for pulsatile and constant blood flow was similar (oxygen: 36-64 mL /L ; carbon dioxide 35-80 mL /L ) for the same mean blood flow ranges. Over all, the results and analyses showed a statistically nonsignificant difference between pulsatile and nonpulsatile flow. Consequently, we conclude that the implementation of pulsatile blood flow has only a small to no effect on the gas exchange performance in an oxygenator. As the results were obtained using an oxygenator with a coiled fiber bundle, the test must be verified for a stacked fiber oxygenator.

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“…9 b), this influence might be caused from this mean flow difference. This finding is consistent with a recent report claiming that pulsatile blood flow has only a small to no effect on the gas exchange performance in an oxygenator [ 28 ]. Therefore, it implies pulsatile operation using speed modulation would not influence the gas exchange much while could improve the hemodynamics (including pulsatility) enormously.…”

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“…Lotte Schraven et al of RWTH Aachen University, Aachen, Germany, investigated the optimization of extracorporeal membrane oxygenation (ECMO) and specifically pulsatile blood flow through the oxygenator. From the literature they could not identify a general statement about the effect of pulsatile blood flow on the gas exchange performance so they performed a structured study.…”

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