Abstract:BACKGROUNDRecent level 1 data indicate that minimally invasive gastrectomy achieves better short-term outcomes than open technique without compromising oncologic efficacy. The robotic technique of total gastrectomy exhibits particular utility for technically challenging resections of locally advanced lesions for which extended lymphadenectomy and vascular dissection are indicated. 1
METHODSThe video demonstrates stepwise technical aspects of robot-assisted D2 total gastrectomy with hand-sewn Rouxen-Y esophagoj… Show more
“…Finally, robotic outcomes were analyzed according to intention to treat and spanned the entire learning curve to maximize early detection of serious, unanticipated adverse events associated with adoption of the new procedure. The surgical technique for robot-assisted D2 radical gastrectomy (18) adapts the open technique for extended lymphadenectomy around the celiac trunk and esophageal reconstruction to a minimally-invasive approach (12). The technique incorporates three-dimensional vision, tremor filtration, motion scaling and wristed motion necessary for dissection and reconstruction of the esophagus through the diaphragmatic hiatus (31).…”
Section: Discussionmentioning
confidence: 99%
“…The technique for robotic D2 total gastrectomy has been previously reported by our group (18). Patients are placed supine in 15 degrees anti-Trendelenburg position.…”
Section: Description Of the Surgical Proceduresmentioning
Background: This study compares standard of care (SOC) open and robotic D2-gastrectomy for locally advanced gastric cancer (LAGC) in the Western context of low disease prevalence, reduced surgical volume, and neoadjuvant chemotherapy (NAC). We hypothesized that robotic gastrectomy (RG) after NAC reduces treatment burden for LAGC across multiple outcome domains vs. SOC.Methods: Single institution, interrupted time series comparing SOC (2008)(2009)(2010)(2011)(2012)(2013) for LAGC (T 2-4 N any / T any N + ) vs. NAC + RG (2013)(2014)(2015)(2016)(2017)(2018). Treatment burden was a composite metric of narcotic consumption, oncologic efficacy, cumulative morbidity, and 90-day resource utilization. Predictors were evaluated via multivariate modeling. Learning curve analysis was done using CUSUM.Results: After exclusions, 87 subjects with equivalent baseline characteristics, aside from male sex, were treated via SOC (n=55) or NAC + RG (n=32). All four domains of treatment burden were significantly reduced in the NAC + RG cohort compared to SOC (P=0.003). The odds ratio for excess treatment burden in the NAC/RG was 0.23 (95% CI: 0.07-0.72, P=0.0117) vs. SOC upon multivariable modeling, whereas the extent of resection (total/subtotal), tumor size, T-stage, sex, and early learning curve had no effect. Differences in treatment burden persisted in subgroup analysis for NAC (n=51).Conclusions: NAC + RG was associated with decreased treatment burden relative to SOC for LAGC.Frequencies of unfavorable hospitalization, adverse oncological outcomes, major morbidity, and narcotic consumption all decreased in this interrupted time series.
“…Finally, robotic outcomes were analyzed according to intention to treat and spanned the entire learning curve to maximize early detection of serious, unanticipated adverse events associated with adoption of the new procedure. The surgical technique for robot-assisted D2 radical gastrectomy (18) adapts the open technique for extended lymphadenectomy around the celiac trunk and esophageal reconstruction to a minimally-invasive approach (12). The technique incorporates three-dimensional vision, tremor filtration, motion scaling and wristed motion necessary for dissection and reconstruction of the esophagus through the diaphragmatic hiatus (31).…”
Section: Discussionmentioning
confidence: 99%
“…The technique for robotic D2 total gastrectomy has been previously reported by our group (18). Patients are placed supine in 15 degrees anti-Trendelenburg position.…”
Section: Description Of the Surgical Proceduresmentioning
Background: This study compares standard of care (SOC) open and robotic D2-gastrectomy for locally advanced gastric cancer (LAGC) in the Western context of low disease prevalence, reduced surgical volume, and neoadjuvant chemotherapy (NAC). We hypothesized that robotic gastrectomy (RG) after NAC reduces treatment burden for LAGC across multiple outcome domains vs. SOC.Methods: Single institution, interrupted time series comparing SOC (2008)(2009)(2010)(2011)(2012)(2013) for LAGC (T 2-4 N any / T any N + ) vs. NAC + RG (2013)(2014)(2015)(2016)(2017)(2018). Treatment burden was a composite metric of narcotic consumption, oncologic efficacy, cumulative morbidity, and 90-day resource utilization. Predictors were evaluated via multivariate modeling. Learning curve analysis was done using CUSUM.Results: After exclusions, 87 subjects with equivalent baseline characteristics, aside from male sex, were treated via SOC (n=55) or NAC + RG (n=32). All four domains of treatment burden were significantly reduced in the NAC + RG cohort compared to SOC (P=0.003). The odds ratio for excess treatment burden in the NAC/RG was 0.23 (95% CI: 0.07-0.72, P=0.0117) vs. SOC upon multivariable modeling, whereas the extent of resection (total/subtotal), tumor size, T-stage, sex, and early learning curve had no effect. Differences in treatment burden persisted in subgroup analysis for NAC (n=51).Conclusions: NAC + RG was associated with decreased treatment burden relative to SOC for LAGC.Frequencies of unfavorable hospitalization, adverse oncological outcomes, major morbidity, and narcotic consumption all decreased in this interrupted time series.
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