Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

Peng, Qian; Deng, Zhiyuan; Pān, Hào; Gu, Liqun; Liu, Ousheng; Tang, Zhangui

doi:10.3892/ol.2017.7491

Cited by 74 publications

(72 citation statements)

References 80 publications

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“…MAPK pathway is known to play a role in promoting cell proliferation, inhibiting apoptosis, promoting tumor angiogenesis and inducing invasion and metastasis in oral cancer. 30 We have previously observed marked overexpression and activation of MAPK1 in OKF6/ TERT1 cells chronically exposed to cigarette smoke. 12 Despite distinct genomic anomalies in OKF6/TERT1 cells chronically treated with cigarette smoke and shisha extract, interferon-signaling cascade was a commonly affected pathway in both models.…”

Section: Discussionmentioning

confidence: 91%

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Patil

Patel

Advani

et al. 2019

J Oral Pathology Medicine

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Background Tobacco is smoked in different form including cigarettes and water pipes. One popular form of water pipe smoking especially in Middle Eastern countries is shisha smoking. Shisha has been associated with various diseases including oral cancer. However, genomic alterations and gene expression changes associated with chronic shisha exposure have not been previously investigated. Objectives Whole‐exome sequencing and gene expression profiling of immortalized human oral keratinocytes (OKF6/TERT1) cells chronically treated with 0.5% shisha extract for a period of 8 months was undertaken to characterize molecular alterations associated with shisha exposure. Methods Genomic DNA and RNA were extracted and preprocessed as per manufacturer's instruction and subjected to whole‐exome and transcriptome sequencing using Illumina HiSeq2500 platform. Exome was analyzed using GATK pipeline whereas RNA‐Seq data was analyzed using HiSat2 and HTSeq along with DESeq to elucidate differentially expressed genes. Results Whole‐exome sequence analysis led to identification of 521 somatic missense variants corresponding to 389 genes RNA‐Seq data revealed 247 differentially expressed genes (≥2‐fold, P‐value<0.01) in shisha treated cells compared to parental cells. Pathway analysis of differentially expressed genes revealed that interferon‐signaling pathway was significantly affected. We predict activation of MAPK1 pathway which is known to play a key role in oral cancer. We also observed allele specific expression of mutant LIMA1 based on RNA‐Seq dataset. Conclusion Our findings provide insights into genomic alterations and gene expression pattern associated with oral keratinocytes chronically exposed to shisha.

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Section: Discussionmentioning

confidence: 91%

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Patil

Patel

Advani

et al. 2019

J Oral Pathology Medicine

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“…This feature was nicely described in a recent review [56]. This activity is mainly linked to its antioxidant effect, its capacity to decrease proliferative growth, the arrest of the cell cycle, and its proapoptotic properties [100][101][102][103][104][105][106]. In the last period, further studies have tried to increase the set of information related to mechanism of action, using esophagus, breast, bronchial epithelial, NSLC (non-small cell lung cancer), and colon cancer cell lines.…”

Section: Apigeninmentioning

confidence: 87%

Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties

Barreca

Mandalari

Calderaro

et al. 2020

Plants

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Citrus spp. are among the most widespread plants cultivated worldwide and every year millions of tons of fruit, juices, or processed compounds are produced and consumed, representing one of the main sources of nutrients in human diet. Among these, the flavonoids play a key role in providing a wide range of health beneficial effects. Apigenin, diosmetin, luteolin, acacetin, chrysoeriol, and their respective glycosides, that occur in concentrations up to 60 mg/L, are the most common flavones found in Citrus fruits and juices. The unique characteristics of their basic skeleton and the nature and position of the substituents have attracted and stimulated vigorous investigations as a consequence of an enormous biological potential, that manifests itself as (among other properties) antioxidant, anti-inflammatory, antiviral, antimicrobial, and anticancer activities. This review analyzes the biochemical, pharmacological, and biological properties of Citrus flavones, emphasizing their occurrence in Citrus spp. fruits and juices, on their bioavailability, and their ability to modulate signal cascades and key metabolic enzymes both in vitro and in vivo. Electronic databases including PubMed, Scopus, Web of Science, and SciFinder were used to investigate recent published articles on Citrus spp. in terms of components and bioactivity potentials.

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“…Oxidative stress, mitochondrial dysfunction, accumulation of intracellular lipid derivatives, and in ammation (via IL-6 and TNFα) contribute to decreased activation of signaling molecules including PI3K and AKT leading to insulin resistance [45][46][47].The absence of sphingomyelin, a second messenger functions in a variety of cellular signaling pathways, leads to a shortened lifespan in animals and it suggests that sphingolipid signaling may play a role in neuronal function and animal stress response during aging [48]. The focal adhesion, mitogen-activated protein kinase (MAPK) signaling pathway and ErbB signaling pathway is module that is involved in cell proliferation, differentiation and migration [49][50][51].Focal adhesion, a signaling molecule associated with cell survival, relies on the interaction between integrins and actin to connect cells to the extracellular matrix [50]. Studies have shown that extracellular matrix proteins-cell interactions gives rise to target organ damage, and in ammatory pathways leading to calci cation or atherosclerosis [1,52].…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology-based strategy to investigate pharmacological mechanisms of Ginkgo Biloba Extract for Aging

Liu

Zhang

et al. 2020

Preprint

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Background Aging represents the main risk factor for a number of debilitating diseases and contributes to increase in mortality. Previous studies have shown that ginkgo biloba extract (EGb) can prevent and treat aging-related diseases, but its pharmacological effects need to be further clarified. In this study, we proposed a network pharmacology-based method to identify the therapeutic pathways of EGb for aging.Methods The active components of EGb and targets of sample chemicals were obtained from TCMSP database. Aging-related genes were obtained by retrieving the Human Ageing Genomic Resources database and the JenAge Ageing Factor Database. Then, a network containing the interactions between the putative targets of EGb and known therapeutic targets of aging was built, which was used to investigate pharmacological mechanisms of EGb for Aging.Results 24 active components, 154 targets of active components of EGb and 308 targets of aging were obtained. Network construction and pathway enrichment were carried out after data integration. The research found that flavonoids (quercetin, luteolin, kaempferol) and beta-sitosterol might be the main active component of EGb. The top eight candidate targets, including PTGS2, PPARG, DPP4, GSK3B, CCNA2, AR, MAPK14, ESR1, were chosen as EGb’s main therapeutic targets. The results of pathway enrichment participated in various pathways associated with inhibiting oxidative stress, inhibiting inflammation, ameliorating insulin resistance and regulating cellular biological processes, etc. Molecular docking results showed that PPARG had better binding capacity with beta-sitosterol and PTGS2 had better binding capacity with kaempferol and quercetin.Conclusions The main components of EGb might act on multiple targets, such as PTGS2, PPARG, DPP4, GSK3B, etc., to regulate multiple pathways and played an anti- aging role by inhibiting oxidative stress, inhibiting inflammation, ameliorating insulin resistance.

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Mitogen-activated protein kinase signaling pathway in oral cancer (Review)

Cited by 74 publications

References 80 publications

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Multiomic analysis of oral keratinocytes chronically exposed to shisha

Citrus Flavones: An Update on Sources, Biological Functions, and Health Promoting Properties

Network pharmacology-based strategy to investigate pharmacological mechanisms of Ginkgo Biloba Extract for Aging

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