Inhibitory effect of the green tea molecule EGCG against dengue virus infection

Raekiansyah, Muhareva; Buerano, Corazon C.; Luz, Mark Anthony de Vera; Morita, Kouichi

doi:10.1007/s00705-018-3769-y

Cited by 41 publications

(22 citation statements)

References 24 publications

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“…Catechins as a class of polyphenolic flavonoids are the main active ingredients of green tea as well as many other teas, which among other properties can strengthen the immunity against viral, especially influenza infections (141). The most prominent of these, epigallocatechin gallate (EGCG), even inhibited dengue virus infection in vitro regardless of the serotype and at concentrations reasonable for pharmacological application (142). Several epidemiological studies have suggested that regular consumption of green tea decreases influenza infection rates (143), while clinical trials have mostly used standardized catechin extracts.…”

Section: Green Teamentioning

confidence: 99%

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

et al. 2020

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Background: During the COVID-19 pandemic people are facing risks of adverse health effects due to the restrictions implemented such as quarantine measures, reduced social contact, and self-isolation. In this qualitative review, we collected data on potential preventive and therapeutic health benefits of Complementary and Integrative Medicine (CIM) that might be useful during the COVID-19 pandemic. We have reviewed the scientific literature to summarize CIM practices that could be beneficial for improving physical and mental health and well-being of the population under the current pandemic circumstances. It must be noted that this review is not SARS-CoV-2 specific and we explicitly do not intend to make any SARS-CoV-2 specific health claims in this article.Methods and Findings: A qualitative, non-systematic literature review was conducted in Medline to identify literature describing preventive and therapeutic CIM approaches for strengthening mental and physical health. For a variety of CIM approaches clinical evidence was identified, indicating beneficial effects. CIM approaches include specific dietary measures and selected micronutrients, physical activity, techniques from Mind-Body Medicine, single botanicals or botanical compounds, and spending time in nature among others. The effects of CIM measures on conditions like obesity and hypertension are of special relevance here, as these conditions are considered as risk factors for a severe course of COVID-19. Moreover, a possibly direct effect of CIM approaches on immune functions and clinical parameters in respiratory tract infections, such as influenza, were identified. The findings of this review could be helpful for clinicians, patients, and the general population during the current pandemic when discussing and/or considering CIM options.Conclusions: CIM offers a variety of preventive and therapeutic options for strengthening physical and mental resilience, which could also be useful in the current COVID-19 pandemic. The evidence of CIM approaches with a potential benefit in the COVID-19 pandemic in different areas is worth to be analyzed. While this qualitative review has several obvious limitations, it might serve as useful starting point for further research on this topic.

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Section: Green Teamentioning

confidence: 99%

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

et al. 2020

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“…In 2018, Raekiansyah et al [24] reported that EGCG ( 1 ) inhibited DENV infection regardless of the infecting serotype and the 50% effective concentration of EGCG in Vero cells was estimated to be approximately 14.8 μM, 18.0 μM, 11.2 μM, and 13.6 μM for DENV-1, DENV-2, DENV-3, and DENV-4, respectively. However, no or minimal inhibition was observed with other flavivirus, including JEV, YFV, and ZIKV, contradicting previous reports by Carneiro [20] and Vázquz-Calvo [23].…”

Section: Antiviral Activity Of Catechins On Enveloped (+) Ssrna VImentioning

confidence: 99%

“…Regarding these biological properties, EGCG ( 1 ) has been reported to possess a broad spectrum of antiviral activities against DNA viruses such as herpes simplex virus (HSV; Herpesviridae ) [5,6,7,8,9,10,11], adenovirus ( Adenoviridae ) [10,12], human papilloma virus (HPV; Papovaviridae ) [13], and hepatitis B virus (HBV; Hepadnaviridae ) [14], and against (+)-RNA viruses such as hepatitis C virus (HCV; Flaviviridae ) [10,15,16,17,18,19], Zika virus (ZIKV; Flaviviridae ) [20,21,22,23], dengue virus (DENV; Flaviviridae ) [23,24], West Nile viruses (WNV; Flaviviridae ) [23], Chikungunya virus (CHIKV; Togaviridae ) [25], and Porcine Reproductive and Respiratory virus (PRRS; Atteriviridae ) [26], and (−)-RNA viruses such as human immunodeficiency virus (HIV; Retroviridae ) [27,28,29,30,31,32,33,34,35,36], Ebola virus (EBOV; Filoviridae ) [37] and influenza virus ( Orthomyxoviridae ) [2,10,38,39,40,41,42,43,44,45,46,47,48]. …”

Section: Introductionmentioning

confidence: 99%

Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters

2018

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Epigallocatechin-3-O-gallate (EGCG) is the major catechin component of green tea (Cameria sinensis), and is known to possess antiviral activities against a wide range of DNA viruses and RNA viruses. However, few studies have examined chemical modifications of EGCG in terms of enhanced antiviral efficacy. This paper discusses which steps of virus infection EGCG interferes with, citing previous reports. EGCG appears most likely to inhibits the early stage of infections, such as attachment, entry, and membrane fusion, by interfering with viral membrane proteins. According to the relationships between structure and antiviral activity of catechin derivatives, the 3-galloyl and 5′-OH group of catechin derivatives appear critical to antiviral activities. Enhancing the binding affinity of EGCG to virus particles would thus be important to increase virucidal activity. We propose a newly developed EGCG-fatty acid derivative in which the fatty acid on the phenolic hydroxyl group would be expected to increase viral and cellular membrane permeability. EGCG-fatty acid monoesters showed improved antiviral activities against different types of viruses, probably due to their increased affinity for virus and cellular membranes. Our study promotes the application of EGCG-fatty acid derivatives for the prevention and treatment of viral infections.

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“…Studies have shown that catechins, particularly EGCG, have antimicrobial (Gram-positive and Gram-negative bacteria) ( 87 ) and antiviral activities with different modes of action ( 202 ). The negative effects of catechins were reported, mostly in cultured cells, against a wide range of DNA viruses, including HSV ( 43 , 172 ), human papillomavirus ( 90 ), and hepatitis B virus ( 91 ); against (+)-RNA viruses such as HCV ( 23 ), ZIKV ( 29 , 220 ), DENV ( 173 ), West Nile viruses ( 220 ), Chikungunya virus (CHIKV; Togaviridae) ( 141 ), and porcine reproductive and respiratory virus ( 245 ); and against (−)-RNA viruses such as HIV ( 131 ), Ebola virus ( 180 ), and influenza virus ( 188 ).…”

Section: Antiviral Activities Of Polyphenolsmentioning

confidence: 99%

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

Lévy

Delvin

Marcil

et al. 2020

American Journal of Physiology-Endocrinology and Metabolism

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Much more serious than the previous severe acute respiratory syndrome (SARS) coronavirus (CoV) outbreaks, the novel SARS-CoV-2 infection has spread speedily, affecting 213 countries and causing ~17,300,000 million cases and ~672,000 (~+1500/day) deaths globally (as of July 31th, 2020). The potentially fatal COVID-19, caused by air droplets and airborne as the main transmission modes, clearly induces a spectrum of respiratory clinical manifestations, but it also affects the immune, gastrointestinal, hematological, nervous and renal systems. The dramatic scale of disorders and complications arise from the inadequacy of current treatments, absence of a vaccine and specific anti-COVID-19 drugs to suppress viral replication, inflammation and additional pathogenic conditions. This highlights the importance of understanding the SARS-CoV-2 mechanisms of actions, and the urgent need of prospecting for new or alternative treatment options. The main objective of the present review is to discuss the challenging issue relative to the clinical utility of plants-derived polyphenols in fighting viral infections. Not only is the strong capacity of polyphenols highlighted in magnifying health benefits, but also the underlying mechanisms are stressed. Finally, emphasis is placed on the potential ability of polyphenols to combat SARS-CoV-2 infection via the regulation of its molecular targets of human cellular binding and replication, as well as through the resulting host inflammation, oxidative stress and signalling pathways.

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Inhibitory effect of the green tea molecule EGCG against dengue virus infection

Cited by 41 publications

References 24 publications

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

The Relevance of Complementary and Integrative Medicine in the COVID-19 Pandemic: A Qualitative Review of the Literature

Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters

Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?

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