Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome

Patel, B. J.; Mann, Giovanni E.; Chapple, Sarah J.

doi:10.1016/j.freeradbiomed.2018.02.004

Cited by 57 publications

(39 citation statements)

References 164 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This leads to increased body weight and fat mass thus increasing risk for hyperglycemia, hyperlipidemia, hyperleptinemia, systemic inflammation, and IR [3]. Both endogenous and exogenous antioxidant supplementation, known to mitigate the negative effects of redox stress, were shown to lower the levels of ROS in these metabolic diseases [40,[68][69][70]. Additionally, in both lean and obese rodent models, dietary interventions, such as those rich in OM3 fatty acids (including EPA and DHA) in contrast to saturated fatty acids (lard diet), also lowered body weight and fat mass, increased insulin sensitivity, and induced browning of white adipose tissue through anti-inflammatory actions [18,23,26,71].…”

Section: Discussionmentioning

confidence: 99%

Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

Amos

Cook

Santanam

2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

View full text Add to dashboard Cite

With obesity rates reaching epidemic proportions, more studies concentrated on reducing the risk and treating this epidemic are vital. Redox stress is an important metabolic regulator involved in the pathophysiology of cardiovascular disease, Type 2 diabetes, and obesity. Oxygen and nitrogenderived free radicals alter glucose and lipid homeostasis in key metabolic tissues, leading to increases in risk of developing metabolic syndrome. Oxidants derived from dietary fat differ in their metabolic regulation, with numerous studies showing benefits from a high omega 3 rich diet compared to the frequently consumed "western diet" rich in saturated fat. Omega 3 (OM3) fatty acids improve lipid profile, lower inflammation, and ameliorate insulin resistance, possibly through maintaining redox homeostasis. This study is based on the hypothesis that altering endogenous antioxidant production and/or increasing OM3 rich diet consumption will improve energy metabolism and maintain insulin sensitivity. We tested the comparative metabolic effects of a diet rich in saturated fat (HFD) and an omega 3-enriched diet (OM3) in the newly developed 'stress-less' mice model that overexpresses the endogenous antioxidant catalase. Eight weeks of dietary intervention showed that mice overexpressing endogenous catalase compared to their wildtype controls when fed an OM3 enriched diet, in contrast to HFD, activated GPR120-Nrf2 crosstalk to maintain balanced energy metabolism, normal circadian rhythm, and insulin sensitivity. These findings suggest that redox regulation of GPR120/FFAR4 might be an important target in reducing risk of metabolic syndrome and associated diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

Amos

Cook

Santanam

2019

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

View full text Add to dashboard Cite

show abstract

“…PPARα is expressed primarily in the liver, kidney, heart, skeletal muscle, and brown adipose tissue, as well as in epithelial cells, macrophages, lymphocytes, and dendritic cells [35]. This isoform stimulates the expression of enzyme genes involved in β-oxidation and regulates the metabolism of lipids, carbohydrates, and amino acids [36].…”

Section: Peroxisome Proliferator-activated Receptorsmentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

et al. 2020

View full text Add to dashboard Cite

The complexity of the pathogenetic mechanisms of the development of chronic inflammation in asthma determines its heterogeneity and insufficient treatment effectiveness. Nuclear transcription factors, which include peroxisome proliferatoractivated receptors, that is, PPARs, play an important role in the regulation of initiation and resolution of the inflammatory process. The ability of PPARs to modulate not only lipid homeostasis but also the activity of the inflammatory response makes them an important pathogenetic target in asthma therapy. At present, special attention is focused on natural (polyunsaturated fatty acids (PUFAs), endocannabinoids, and eicosanoids) and synthetic (fibrates, thiazolidinediones) PPAR ligands and the study of signaling mechanisms involved in the implementation of their anti-inflammatory effects in asthma. This review summarizes current views on the structure and function of PPARs, as well as their participation in the pathogenesis of chronic inflammation in asthma. The potential use of PPAR ligands as therapeutic agents for treating asthma is under discussion.

show abstract

“…Table. Compounds tentatively identified as candidate constituents of Maerua subcordata. These compounds are reported in the literature to be ligands of PPARγ and/or influence PPARγ functions [47,56,61,[79][80][81][82][83][84][85][86][87][88][89][90][91].…”

Section: Supplementary Informationmentioning

confidence: 99%

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Hiben

Haan

Spenkelink

et al. 2020

BMC Complement Med Ther

View full text Add to dashboard Cite

Background: The health benefits of botanicals is linked to their phytochemicals that often exert pleiotropic effects via targeting multiple molecular signaling pathways such as the peroxisome proliferator-activated receptors (PPARs) and the nuclear factor kappaB (NFκB). The PPARs are transcription factors that control metabolic homeostasis and inflammation while the NF-κB is a master regulator of inflammatory genes such as the inducible nitric-oxide synthase that result in nitric oxide (NO) overproduction. Methods: Extracts of Maerua subcordata (MS) and selected candidate constituents thereof, identified by liquid chromatography coupled to mass spectroscopy, were tested for their ability to induce PPARγ mediated gene expression in U2OS-PPARγ cells using luciferase reporter gene assay and also for their ability to inhibit lipopolysaccharide (LPS) induced NO production in RAW264.7 macrophages. While measuring the effect of test samples on PPARγ mediated gene expression, a counter assay that used U2OS-Cytotox cells was performed to monitor cytotoxicity or any non-specific changes in luciferase activity.

show abstract

Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome

Cited by 57 publications

References 164 publications

Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

Omega 3 rich diet modulates energy metabolism via GPR120-Nrf2 crosstalk in a novel antioxidant mouse model

Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

Induction of peroxisome proliferator activated receptor γ (PPARγ) mediated gene expression and inhibition of induced nitric oxide production by Maerua subcordata (Gilg) DeWolf

Contact Info

Product

Resources

About