Utilidad del ultrasonido endobronquial para el diagnóstico y etapificación del cáncer pulmonar

Labarca, Gonzalo; Caviedes, Iván; Folch, Erik; Majid, Adnan; Fernández-Bussy, Sebastián

doi:10.4067/s0034-98872017000901165

Cited by 4 publications

(2 citation statements)

References 22 publications

(26 reference statements)

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“…Although in the last decade several chemical animal models of PD have been established, most of them missed some pathophysiological features of the disease (Potashkin et al, 2010 ; Bezard et al, 2013 ; Folch et al, 2017 ). Moreover, in contrast to the experimental models of DA neuron degeneration based on toxic insults, in which a toxin is injected locally in different basal ganglia structures, the Rhes KO animal model might provide new insights into the basal ganglia structures more vulnerable to DA neuron degeneration and might help in clarifying the mechanism of idiopathic PD, where the mechanism of neurodegeneration of DA neurons is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

Costa

Pinna

Porceddu

et al. 2018

Front. Aging Neurosci.

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We have recently shown that male Rhes knockout (KO) mice develop a mild form of spontaneous Parkinson’s disease (PD)-like phenotype, characterized by motor impairment and a decrease in nigrostriatal dopamine (DA) neurons. Experimental evidence has implicated neuroinflammation in PD progression, and the presence of activated glial cells has been correlated with DA neuron degeneration. Despite this, several factors, such as gender, have been found to affect DAergic neuron degeneration and influence neuroinflammation, explaining the differences between men and women in the etiology of PD. On these basis, we studied age and gender differences in DA neuron degeneration and gliosis in the nigrostriatal system of adult (3-month-old) and middle aged (12-month-old) male and female Rhes wild-type (WT) and KO mice. Through immunohistochemistry, tyrosine hydroxylase (TH), microglial (complement type 3 receptor [CD11b]) and astroglial (glial fibrillary acid protein [GFAP]) increase, were evaluated. Adult male Rhes KO mice showed a decrease in TH and an increase in CD11b, both in the caudate putamen (CPu) and substantia nigra pars compacta (SNc), and an increase in GFAP in the CPu. In contrast, adult female Rhes KO mice showed only a decrease in TH in the SNc, whereas no modifications to the levels of GFAP and CD11b were observed in the CPu or SNc. Middle aged male Rhes KO mice showed a decrease in TH in the CPu and SNc, and an increase in GFAP and CD11b in the SNc. Middle aged female Rhes KO mice showed a decrease in TH in the CPu and SNc and an increase in CD11b only in the CPu, but no modifications to GFAP levels. The more marked DA neuron degeneration and neuroinflammation in male compared with female Rhes KO mice, while confirming the role of Rhes as an important protein for DA neuron survival, gives support to Rhes KO mice as a valuable preclinical model for studying the vulnerability factors of DA neuron degeneration as in PD.

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Section: Discussionmentioning

confidence: 99%

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

Costa

Pinna

Porceddu

et al. 2018

Front. Aging Neurosci.

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“…Con respecto al EBUS-TBNA, existen dos modalidades diagnósticas, la lineal y la radial. Para el estudio de las lesiones periféricas la más utilizada es la radial (R-EBUS) 20 . En un metaanálisis de Steinford et al, donde se incluyeron 16 estudios con un total de 1.420 pacientes, concluyeron que este examen contaba con una sensibilidad o rendimiento diagnóstico de 73% (IC: 0,70-0,76) y que variaba de 49 a 88% en los distintos estudios.…”

Section: Discussionunclassified

Caracterización de nódulos pulmonares resecados. Experiencia de manejo por un programa multidisciplinario

et al. 2018

Rev. méd. Chile

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Features of excised pulmonary nodules in 100 patients Background: Pulmonary nodules are common, and surgery is the only alternative that allows a diagnostic and therapeutic management in a single procedure. Aim: To report the epidemiological, radiological, surgical and pathological features of excised pulmonary nodules. Material and Methods: Review of medical records of patients in whom a pulmonary nodule was excised between 2014 and 2018. Those with incomplete data or without a pathological study were excluded from analysis. Results: We retrieved 108 records and 8 had to be excluded, therefore 100 patients aged 34 to 82 years (57% females) were analyzed. Sixty percent had a history of smoking. Mean nodule size was 16 mm and the solid type was the most common (65%). Forty five percent of nodules had irregular margins and 55% were in the superior lobes. All patients operated by video-assisted thoracoscopic surgery and 40% underwent a lobectomy. Malignant lesions were observed in 87% of biopsies and a pulmonary adenocarcinoma was found in pathology in 40%. Conclusions: A multidisciplinary approach of pulmonary nodules, using adapted international guidelines, accomplishes an appropriate management, decreasing unnecessary surgical interventions.

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Endobronchial ultrasound-guided transbronchial needle aspirate for diagnosis of anaplastic large cell lymphoma of unusual presentation: A case report

Sua

Arias

Morales

et al. 2020

Respiratory Medicine Case Reports

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Utilidad del ultrasonido endobronquial para el diagnóstico y etapificación del cáncer pulmonar

Cited by 4 publications

References 22 publications

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

Rhes Counteracts Dopamine Neuron Degeneration and Neuroinflammation Depending on Gender and Age

Caracterización de nódulos pulmonares resecados. Experiencia de manejo por un programa multidisciplinario

Endobronchial ultrasound-guided transbronchial needle aspirate for diagnosis of anaplastic large cell lymphoma of unusual presentation: A case report

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