Dried blood spots and parallel artificial liquid membrane extraction–A simple combination of microsampling and microextraction

Ask, Kristine Skoglund; Øiestad, Elisabeth Leere; Pedersen‐Bjergaard, Stig; Gjelstad, Astrid

doi:10.1016/j.aca.2018.01.024

Cited by 24 publications

(15 citation statements)

References 21 publications

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“…One of the steps to take into account in an analytical method is the isolation and concentration of analytes of interest from the biological samples under study; the most used procedures for extracting antidepressants are liquid-liquid extraction (LLE) [6,17], solid-phase extraction (SPE) [6,[18][19][20], and some miniaturized techniques-such as solidphase microextraction (SPME) [6,21,22], microextraction by packed sorbent (MEPS) [6,[23][24][25], and dispersive liquid-liquid microextraction (DLLME) [6,[26][27][28][29][30][31]. There are also several methods involving gas chromatography (GC) and liquid chromatography (LC) coupled with mass spectrometry (MS) [26,[30][31][32][33][34][35][36][37][38] or tandem mass spectrometry (MS/MS) [27,[39][40][41][42][43], ultraviolet (UV) [22,28,[44][45][46][47][48], fluorescence [25], diode array (DAD) or photodiode array (PDA)…”

Section: Introductionmentioning

confidence: 99%

“…As a way to overcome the disadvantage of classical extraction methods that apply a larger volume of biological sample, miniaturized techniques such as dried matrix spots have been explored, representing a simple and fast procedure compared to other extraction techniques. Applied to blood samples, the technique of dried blood spots (DBS) has been used to determine antidepressants [40,42]. Both the DBS and the dried saliva spots (DSS) techniques have been used in several areas, such as pharmacology, in clinical pharmacokinetic studies, monitoring of drugs, and in the determination of several drugs [59][60][61].…”

Section: Introductionmentioning

confidence: 99%

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New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling

et al. 2021

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The increase in the consumption of antidepressants is a public health problem worldwide, as these are a class of compounds widely used in the treatment of several illnesses, such as depression and anxiety. This work aimed to develop and optimize a method for the quantification of a number of antidepressants and their metabolites (fluoxetine, venlafaxine, O-desmethylvenlafaxine, citalopram, sertraline, and paroxetine) in 100 µL of oral fluid using the dried saliva spots (DSS) sampling approach and gas chromatography coupled with tandem mass spectrometry (GC–MS/MS). The method was validated, presenting linearity within the studied range, with detection and quantification limits ranging between 10 and 100 ng/mL, and coefficients of determination (R2) of at least 0.99 for all analytes. Recoveries were between approximately 13 and 46%. The analysis of precision and accuracy presented acceptable coefficients of variation and relative errors, considering the criteria usually accepted in the validation of bioanalytical procedures. The method herein described is the first to be reported using DSS for the extraction of antidepressants, proving to be a sensitive, simple, and fast alternative to conventional techniques, and capable of being routinely applied in clinical and forensic toxicology scenarios.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling

et al. 2021

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“…Daravani et al [168] This technique showed good results in the extraction of several analytes, including different NPS and polar drugs. Commercial availability of plates for PALME would also facilitate the procedure [189][190][191].…”

Section: Methodsmentioning

confidence: 99%

A review of the application of hollow-fiber liquid-phase microextraction in bioanalytical methods – A systematic approach with focus on forensic toxicology

Venson

Korb

Cooper

2019

Journal of Chromatography B

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Over the past three decades, many studies employing hollow-fiber liquid-phase microextraction (HF-LPME) bioanalytical methods have been published. The basic mechanism of extraction relies on the migration of the analytes through a liquid membrane sustained in the pores of the walls of a porous hollow fiber, and from there into an acceptor phase present in the lumen of the fiber. The mass transfer occurs by passive diffusion and it can be enhanced by using a carrier or applying an electrical potential across the phases. This type of extraction method presents many advantages over classical techniques, such as high preconcentration factor, clean extracts, and a green chemistry approach. Due to its advantages, and considering that no study systematically compiled the characteristics of the published methods in one single accessible source of information, the aim of this systematic review is to assess the data regarding bioanalytical methods, compile, and analyse the studies published until up to October of 2017. The data source used for the systematic review were Pubmed, Web of Science, and Science Direct, and 171 studies were included in the final review by two independent reviewers, resulting in a reliable and accessible source of information about bioanalytical methods employing HF-LPME.

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“…The PALME has been used for the treatment of biological samples like plasma [23] or whole blood [24] and recently for a food matrix (wine) [25]. Its application to nonpolar compounds was performed at many occasions: whether for basic [24,26,[28][29][30][31][32] or acidic [27,30,31,33] products. Such as HF-LPME, PALME technique is generally recommended for the extraction of moderately to non-polar compounds (log P> 1.5-2) [21,34].…”

Section: Introductionmentioning

confidence: 99%

Parallel artificial liquid membrane extraction of organophosphorus nerve agent degradation products from environmental samples

Bouchouareb

Combès

Pichon

2022

Analytica Chimica Acta

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Dried blood spots and parallel artificial liquid membrane extraction–A simple combination of microsampling and microextraction

Cited by 24 publications

References 21 publications

New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling

New Method for the Monitoring of Antidepressants in Oral Fluid Using Dried Spot Sampling

A review of the application of hollow-fiber liquid-phase microextraction in bioanalytical methods – A systematic approach with focus on forensic toxicology

Parallel artificial liquid membrane extraction of organophosphorus nerve agent degradation products from environmental samples

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