Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma

Tourlaki, Athanasia; Genovese, Giovanni; Consonni, Dario; Brambilla, Lucia

doi:10.23736/s0392-0488.18.05765-6

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…Tourlaki et al assessed the effect of using a detergent containing dihydroavenanthramide D 5% + 1% menthol moisturizer daily. They found that the intervention improved chronic pruritus associated with xerosis in elderly adults with Kaposi's sarcoma (Tourlaki et al, 2020).…”

Section: Clinical Applicationmentioning

confidence: 99%

Menthol: An underestimated anticancer agent

et al. 2023

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Menthol, a widely used natural, active compound, has recently been shown to have anticancer activity. Moreover, it has been found to have a promising future in the treatment of various solid tumors. Therefore, using literature from PubMed, EMBASE, Web of Science, Ovid, ScienceDirect, and China National Knowledge Infrastructure databases, the present study reviewed the anticancer activity of menthol and the underlying mechanism. Menthol has a good safety profile and exerts its anticancer activity via multiple pathways and targets. As a result, it has gained popularity for significantly inhibiting different types of cancer cells by various mechanisms such as induction of apoptosis, cell cycle arrest, disruption of tubulin polymerization, and inhibition of tumor angiogenesis. Owing to the excellent anticancer activity menthol has demonstrated, further research is warranted for developing it as a novel anticancer agent. However, there are limitations and gaps in the current research on menthol, and its antitumor mechanism has not been completely elucidated. It is expected that more basic experimental and clinical studies focusing on menthol and its derivatives will eventually help in its clinical application as a novel anticancer agent.

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Section: Clinical Applicationmentioning

confidence: 99%

Menthol: An underestimated anticancer agent

et al. 2023

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“…In the elderly, Kaposi sarcoma can be fatal; according to the stage and clinical presentation, the treatment consists in a combination of chemotherapy and radiotherapy. Xerosis is a common clinical finding in this population (24,29).…”

Section: Medical Literaturementioning

confidence: 82%

“…In addition, between 2000 and 2008, the usage of antiretrovirals among the U.S. population increased (26,27).…”

Section: Medical Literaturementioning

confidence: 99%

"Particularities of Cancer Management in HIV+ Patients. Clinical Case Kaposi’s Sarcoma-Visceral Form"

Florescu¹,

Pîrvu²

2023

JMRO

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"Globally, 35 million people are infected with HIV, and this population is at a higher risk of developing cancer. We are reporting the case of a 44-year-old HIV-positive male patient. He smokes and drinks occasionally, but he is otherwise in good health. He was diagnosed with a visceral form of Kaposi sarcoma in January 2022 and has undergone 12 cycles of oncologic treatment with liposomal doxorubicin at our facility."

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“…Eine In der topischen Therapie hat bereits die wirkstofffreie Basistherapie mit Emollientien einen hohen Stellenwert, denn die Hydratisierung und Stabilisierung der physiologischen Hautbarriere kann den mit trockener Haut assoziierten Pruritus effizient lindern (Izumi et al 2017;Tourlaki et al 2020).…”

Section: Therapeutische Optionenunclassified

Aktivatoren von KNa1.1-Kanälen für die Therapie von Schmerz und Pruritus

Balzulat

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Der Natrium-abhängige Kaliumkanal Slack (KNa1.1, Slo2.2, KCNT1) nimmt eine Schlüsselrolle in der Regulation neuronaler Erregbarkeit ein, indem er die Ausbildung und Feuerungsfrequenz von Aktionspotentialen kontrolliert. Sowohl in Mäusen als auch in Menschen wird Slack besonders hoch in nicht-peptidergen C-Faser-Neuronen exprimiert. Wissenschaftliche Erkenntnisse der letzten Jahre konnten die Beteiligung von Slack-Kanälen in der Signalverarbeitung neuropathischer Schmerzen, aber auch in verschiedenen Arten von Pruritus, feststellen. Dabei zeigen Slack-defiziente Mäuse ein verstärktes mechanisches Schmerzverhalten nach einer peripheren Nervenverletzung und ein erhöhtes Kratzverhalten in akuten Juckreiz-Modellen. Das als Slack-Aktivator identifizierte trizyklische Neuroleptikum Loxapin zeigt sowohl analgetische als auch antipruritische Effekte in Mäusen, jedoch ist sein klinischer Einsatz auf Grund schwerwiegender antipsychotischer Nebenwirkungen limitiert. Basierend auf Loxapins Leitstruktur wurden daher in dieser Arbeit neue Slack-Aktivatoren mit einem verbesserten pharmakologischen Profil designed und ihr Potential für die Therapie von Schmerzen sowie akutem und chronischem Pruritus in vivo untersucht.

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Efficacy of a detergent combined with a moisturizer for the treatment of pruritus associated with xerosis in an elderly population affected by Kaposi's sarcoma

Cited by 3 publications

References 19 publications

Menthol: An underestimated anticancer agent

Menthol: An underestimated anticancer agent

"Particularities of Cancer Management in HIV+ Patients. Clinical Case Kaposi’s Sarcoma-Visceral Form"

Aktivatoren von KNa1.1-Kanälen für die Therapie von Schmerz und Pruritus

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