Hyperbaric oxygen therapy and intermittent ischaemia in the treatment of chronic wounds

Hyperbaric oxygen therapy as adjuvant therapy for odontogenic necrotizing myositis: A case report

“…These properties along with increased dissolved oxygen in plasma lead to better oxygenation of hypoxic tissue, where red blood cells cannot reach. 27 Although numerous studies have clearly outlined the benefits that HBOT can have in the treatment of these diseases, the findings in term of outcome are controversial.…”

“…Hyperbaric oxygen causes reduced platelet aggregation, improved tissue microcirculation, and shortens metabolic disorders. These properties along with increased dissolved oxygen in plasma lead to better oxygenation of hypoxic tissue, where red blood cells cannot reach 27 …”

Visualization and Bibliometric Analysis of Research Trends on Hyperbaric Oxygen Therapy

“…With progress in medical research, the mechanism of action, efficacy, indications, complications and contraindications of HBOT have been gradually verified and confirmed [5]. For example, HBOT can be used as an adjunctive treatment for refractory wounds [6]. In addition, HBOT has therapeutic effects by accelerating the body's physiological metabolism and improving fatigue after exercise [7].…”

Research progress on the biomedical application of microalgae

“…通过简单一步式静电自组装方法将多巴胺修饰的 四氧化三铁磁性纳米颗粒附着于硅藻表面，并用 吲哚美辛和庆大霉素分别验证其载药效果。 近年来，越来越多研究人员开始关注微藻在 生物体内的应用。Zhong 等 [24] 以螺旋藻(Spirulina platensis，蓝藻中的一种)为载体，实现阿霉素的靶 [25][26] 。肿 瘤乏氧将极大影响放疗与光动力治疗等氧依赖疗 法的治疗效果 [27][28] 。因此，改善肿瘤的乏氧微环 境将大大增强肿瘤的放疗/光动力治疗的效果。 既往有研究尝试用纳米粒子在肿瘤原位产氧或给 氧，以期提高治疗效果 [29][30] 。但由于大多数纳米 粒子可被肝脏和脾脏的单核吞噬细胞系统捕获， 仅约 2%能顺利达到肿瘤部位，由此导致的给药剂 量大及全身毒性限制了其应用 [31] 。近年来，许多 研究利用微藻的光合作用原位产氧改善肿瘤的乏 氧情况，增强肿瘤治疗效果。 Zhong 等 [32] 以螺旋藻为载体构建了一种光合 伤口愈合是一个复杂的过程，可以概括为炎 性期、增生期和重塑期三个阶段 [36] ，每个阶段都 有氧气的参与 [37] ，其中细胞增殖、新生血管生成、 胶原合成等修复活动也离不开氧气。但伤口中普 遍存在的血管破裂或收缩妨害了供氧，导致组织 缺氧，不利于伤口愈合。因此，增加伤口局部的氧 气浓度能有效加快伤口愈合 [38] 。目前临床上采 用的高压氧疗或局部气体氧等方法效果一般 [39] ， 而微藻作为天然的光合生物在加快伤口愈合方面 具有得天独厚的优势。 Li 等 [40] 通过羧甲基壳聚糖包覆螺旋藻构建 了一种光合微生物水凝胶，在650 nm激光照射下，…”