El papel de los ácidos grasos libres en la resistencia a la insulina

Vazquez-Jimenez, J. Gustavo; Roura-Guiberna, Adriana; Jiménez-Mena, Luisa Reyna; Olivares-Reyes, J. Alberto

doi:10.24875/gmm.17002714

Cited by 7 publications

(5 citation statements)

References 91 publications

(114 reference statements)

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“…Sin embargo, encontramos secuencias que sugieren la presencia de proteínas receptoras a folistatina (FSTL1), conocidas como Dip2A, que comparte con InR las mismas rutas de señalización en cuanto a la inducción de la proliferación y diferenciación celular (Ouchi et al, 2010;Tanaka et al, 2010). Por otra parte, se ha demostrado que tanto los InR y Dip2A presentan dominios del tipo tirosina quinasa (TyrKc), que son activadas por la vía de las P13K/Akt (fosfatidilinositol 3-quinasa) y participan en el trasporte de glucosa y otros eventos metabólicos (Ouchi et al, 2010;Vázquez-Jiménez et al, 2017). En específico, la proteína Dip2A actúa como receptora de folistatina (FSTL1) en la membrana celular, y pertenece a la superfamilia de factores de crecimiento transformante beta (TGF-β) (Ouchi et al, 2010), la cual está involucrada en varios procesos biológicos como la proliferación, diferenciación y muerte celular en diversos insectos (Tanaka et al, 2010;Ishimaru et al, 2016).…”

Section: Discussionunclassified

Bioprospección de receptores de insulina a partir de ARN mensajero en Brevicoryne brassicae L. (Hemiptera: Aphididae)

Cruz-Méndez

Diego‐García

Liedo

et al. 2022

AZM

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La supresión de moléculas de ácido ribonucleico mensajero (ARNm) mediante ARN interferente (ARNi) se ha propuesto como método de control de insectos plagas. El ARNi impide el desarrollo morfológico y funcional de los insectos y se considera altamente específico. En este estudio se buscaron receptores de insulina (InR) en Brevicoryne brassicae L. (Hemiptera: Aphididae) a partir del ARNm de pulgones, como primer paso para el diseño posterior de ARNi dirigido a la supresión de InR. A partir del ácido desoxirribonucleico complementario (ADNc) y mediante PCR anidada, se amplificó la región correspondiente a InR con dos pares de cebadores diseñados para Nilaparvata lugens (Homoptera: Delphacidae). No se logró identificar InR, en su lugar se predice la presencia de la proteína receptora Dip2A de unión a folistatina (FS) debido a que comparten regiones proteicas similares con los InR, involucradas en la traducción de señales en los insectos. Se sugiere continuar con la búsqueda de InR específicos para el pulgón, así como posibles cebadores para regiones de Dip2A, para lograr un ARNi altamente específico.

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Section: Discussionunclassified

Bioprospección de receptores de insulina a partir de ARN mensajero en Brevicoryne brassicae L. (Hemiptera: Aphididae)

Cruz-Méndez

Diego‐García

Liedo

et al. 2022

AZM

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“…Apart from promoting glucose uptake, this protein monitors the levels of this monosaccharide and other carbohydrates as well as the levels of fatty acids, thus controlling the distribution, use, and storage of these through the activation of metabolic pathways such as glycogenesis, lipogenesis, and protein synthesis. In addition, insulin promotes cell division and growth[ 6 , 8 , 9 ].…”

Section: Insulin Effectsmentioning

confidence: 99%

“…Finally, activated ERK1 and ERK2 can translocate to the nucleus to promote the expression of genes involved in cell differentiation, growth, and proliferation[ 9 , 10 , 17 ]. IR and insulin receptor substrate (IRS) 1/2 proteins, due to their function as coupling proteins, play an essential role in insulin signaling cascade regulation[ 6 ].…”

Section: Insulin Signaling Pathwaymentioning

confidence: 99%

“…One of the mechanisms involved in the development of insulin resistance and hypertension is the chronic activation of the AT1 receptor (AT1R) by angiotensin-II (ANG-II). AT1R activation results in the c-Jun N-terminal kinase (JNK) activation enabling the insulin signaling pathway blocking[ 6 ], thus as a consequence of this mechanism, T2DM patients present higher blood pressure values[ 7 ] and in accordance, patients with HBP have carbohydrate metabolism disturbances[ 5 ].…”

Section: Introductionmentioning

confidence: 99%

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AT1 receptor downregulation: A mechanism for improving glucose homeostasis

Lopez¹,

Casillas²,

Jaramillo³

et al. 2023

World J Diabetes

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There is a pathophysiological correlation between arterial hypertension and diabetes mellitus, established since the pre-diabetic state in the entity known as insulin resistance. It is known that high concentrations of angiotensin-II enable chronic activation of the AT1 receptor, promoting sustained vasoconstriction and the consequent development of high blood pressure. Furthermore, the chronic activation of the AT1 receptor has been associated with the development of insulin resistance. From a molecular outlook, the AT1 receptor signaling pathway can activate the JNK kinase. Once activated, this kinase can block the insulin signaling pathway, favoring the resistance to this hormone. In accordance with the previously mentioned mechanisms, the negative regulation of the AT1 receptor could have beneficial effects in treating metabolic syndrome and type 2 diabetes mellitus. This review explains the clinical correlation of the metabolic response that diabetic patients present when receiving negatively regulatory drugs of the AT1 receptor.

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“…However, the use of these antiretrovirals may increase oxidative stress (OS) because, together with the natural course of the disease, an increase in reactive oxygen species (ROS) and other prooxidant substances have been found in the organism [ 4 , 5 , 6 ]. OS may activate pro-inflammatory signaling pathways, considered risk factors for various chronic degenerative diseases [ 7 , 8 ], the main ones linked to cardiovascular events [ 9 , 10 , 11 ]. Likewise, OS significantly decreases the effectiveness of ART, enhancing the complication of the illness and the appearance of opportunistic conditions [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals

Jiménez-Osorio

Jaen-Vega

Fernández-Martínez

et al. 2022

IJMS

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Human immunodeficiency virus (HIV) infection has continued to be the subject of study since its discovery nearly 40 years ago. Significant advances in research and intake of antiretroviral therapy (ART) have slowed the progression and appearance of the disease symptoms and the incidence of concomitant diseases, which are the leading cause of death in HIV+ persons. However, the prolongation of ART is closely related to chronic degenerative diseases and pathologies caused by oxidative stress (OS) and alterations in lipid metabolism (increased cholesterol levels), both of which are conditions of ART. Therefore, recent research focuses on using natural therapies to diminish the effects of ART and HIV infection: regulating lipid metabolism and reducing OS status. The present review summarizes current information on OS and cholesterol metabolism in HIV+ persons and how the consumption of certain phytochemicals can modulate these. For this purpose, MEDLINE and SCOPUS databases were consulted to identify publications investigating HIV disease and natural therapies and their associated effects.

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El papel de los ácidos grasos libres en la resistencia a la insulina

Cited by 7 publications

References 91 publications

Bioprospección de receptores de insulina a partir de ARN mensajero en Brevicoryne brassicae L. (Hemiptera: Aphididae)

Bioprospección de receptores de insulina a partir de ARN mensajero en Brevicoryne brassicae L. (Hemiptera: Aphididae)

AT1 receptor downregulation: A mechanism for improving glucose homeostasis

Antiretroviral Therapy-Induced Dysregulation of Gene Expression and Lipid Metabolism in HIV+ Patients: Beneficial Role of Antioxidant Phytochemicals

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