Anaplastic thyroid carcinoma in Denmark 1996–2012: A national prospective study of 219 patients

Hvilsom, Gitte Bjørn; Londero, Stefano Christian; Hahn, Christoffer Holst; Schytte, Sten; Pedersen, Henrik C.; Christiansen, Peer; Kiss, Katalin; Larsen, Stine Rosenkilde; Jespersen, Marie Louise; Lelkaitis, Giedrius; Godballe, Christian

doi:10.1016/j.canep.2018.01.011

Cited by 24 publications

(21 citation statements)

References 45 publications

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“…11 The prognosis is extremely poor, with a median 1-year survival rate of only 10%-20%. [12][13][14] The tumor occurs in older persons and is slightly more frequent in women. The patients often Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma.

Hrudka¹,

Švadlenková²

2021

Autops Case Rep

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Section: Discussionmentioning

confidence: 99%

Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma.

Hrudka¹,

Švadlenková²

2021

Autops Case Rep

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“…In anaplastic thyroid carcinoma, cervical lymphadenopathy was present in 64% (7 of 11) of cases in a single institution study in 2018 (Deeken-Draisey et al 2018). Also, 56% of the 219 patients with anaplastic thyroid carcinoma noted in Danish databases have lymph node metastases (Hvilsom et al 2018). Thus, primary thyroid squamous cell carcinoma had higher frequency of lymph node metastases than papillary thyroid carcinoma and similar frequency to anaplastic thyroid carcinoma.…”

Section: Metastasesmentioning

confidence: 97%

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

Lam

2020

Endocrine-Related Cancer

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The aim is to review the features of 117 primary squamous cell carcinomas of thyroid which meet the histological criteria of the World Health Organization classification of endocrine tumours. The carcinomas occur in 83 women and 34 men (female to male ratio is 2.4 to 1) and with median age at presentation of 64. Half of these squamous cell carcinomas of thyroid were moderately differentiated. PAX-8 protein is a sensitive marker for confirming the thyroid origin of the carcinoma. The carcinoma is also positive for p63, p40, cytokeratins 5/6, 7,19 and negative for cytokeratins 20 and 10/13. P53 overexpression is common. The most important differential diagnosis is direct infiltration or metastatic involvement by squamous cell carcinoma from other organs. Limited mutation analysis revealed BRAF mutation in some squamous cell carcinomas of the thyroid. The genetic profile appears to be different from anaplastic thyroid carcinomas. Primary squamous cell carcinoma of thyroid had lymph node involvement in 59% and distant metastases in 26%. The median survival of the patients was 8 months. Curative surgery offers the best survival for the patients with the carcinoma. To conclude, primary squamous cell carcinoma of the thyroid gland has distinctive clinical, pathological and molecular profiles. It is important to recognize this unique variant of thyroid carcinoma for possible curative surgical resection and to do more genomic works on the entity to uncover the molecular pathogenesis.

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“…It accounts for up to 50% of deaths from thyroid cancer 1,2 . Prompt diagnosis and initiation of multimodality treatment are imperative to maximize survival outcomes 3,4 . To date, there is no consensus in the management guidelines of ATC with major vessel involvement 5 .…”

Section: Figurementioning

confidence: 99%

“…1,2 Prompt diagnosis and initiation of multimodality treatment are imperative to maximize survival outcomes. 3,4 To date, there is no consensus in the management guidelines of ATC with major vessel involvement. 5 Most patients receive palliative care while fewer undergo resection in conjunction with either radioactive iodine, radiotherapy, chemotherapy or a combination.…”

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confidence: 99%

Response to multidisciplinary therapy of metastatic anaplastic thyroid cancer involving the right internal jugular vein and superior vena cava

Liang

Ebrahimi

Lee

et al. 2020

ANZ Journal of Surgery

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Response to multidisciplinary therapy of metastatic anaplastic thyroid cancer involving the right internal jugular vein and superior vena cava A 68-year-old female presented with dysphagia, unilateral right upper limb pain, cyanosis, right occipital headache and a 3-month evolving central neck lump. She was otherwise usually fit and well with a background of Graves' disease and radioactive iodine-131 treatment in 2009. Examination revealed a 6-cm firm central neck mass arising from the thyroid and engorged veins over the right supraclavicular fossa. She was euthyroid. On ultrasound, a large multinodular goitre was seen containing a 34-mm Thyroid Imaging Reporting and Data Systems (TIRADS) classification grade 5 nodule in the right lobe, abnormal right cervical lymph nodes (levels 2-4) and occlusive right internal jugular vein (IJV) thrombus (Fig. 1). Fine needle aspiration of the nodule and abnormal lateral neck nodes showed poorly differentiated carcinoma of thyroid origin or squamous cell carcinoma (Bethesda category VI). A working diagnosis of poorly differentiated thyroid carcinoma was favoured over anaplastic thyroid cancer (ATC), given the presence of superior vena cava (SVC) obstruction with central compartment resectable disease and absence of distant metastasis. A total thyroidectomy, central and radical right lateral lymph node clearance, was performed. The right IJV was resected and a thrombectomy was performed. Tumour embolus was evident when the right IJV was transected from the brachiocephalic vein. The right recurrent laryngeal nerve was not involved and preserved, as confirmed with an intraoperative nerve integrity monitor. Post-operatively, her recovery was complicated by pneumonia and a pulmonary embolus which responded well to standard treatments. The patient was successfully discharged home after 5 days.

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Anaplastic thyroid carcinoma in Denmark 1996–2012: A national prospective study of 219 patients

Cited by 24 publications

References 45 publications

Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma.

Small bowel perforation and death caused by anaplastic thyroid carcinoma metastasis in a patient with concomitant colonic and bilateral breast carcinoma.

Squamous cell carcinoma of thyroid: a unique type of cancer in World Health Organization Classification

Response to multidisciplinary therapy of metastatic anaplastic thyroid cancer involving the right internal jugular vein and superior vena cava

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