Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African–Caribbean and Caucasian patients

Figiel, Sandy; Pinault, Michelle; Domingo, Isabelle; Guimaraes, Cyrille; Guibon, Roseline; Besson, Pierre; Tavernier, Elsa; Blanchet, Pascal; Multigner, Luc; Bruyère, F.; Haillot, O.; Mathiéu, Romain; Vincendeau, S.; Rioux‐Leclercq, Nathalie; Lebdai, Souhil; Azzouzi, Abdel-Rahmène; Perrouin‐Verbe, Marie‐Aimée; Fournier, Georges; Doucet, Laurent; Rigaud, J.; Renaudin, Karine; Mahéo, Karine; Fromont, Gaëlle

doi:10.1016/j.ejca.2017.12.017

Cited by 28 publications

(30 citation statements)

References 33 publications

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“…Observational cohort studies indicate that the dietary intake of eicosapentaenoic (EPA; 20:5n−3), docosahexaenoic (DHA; 22:6n−3) may decrease the risk of PCa [ 191 ], whereas, according to animal studies, the intake of long-chain n-6 fatty acids enhances prostate tumor cell growth [ 192 ]. On the other hand, a decrease in the fatty acid content of the peri-prostatic adipose tissue has been observed with PCa aggressiveness [ 193 ]. Nevertheless, despite the ample research conducted on the subject, a salient explanation of the effect of FA intake on PCa is yet expected [ 194 , 195 ].…”

Section: Fatty Acids (Fa) and Foods Rich In Fatty Acidsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (Ganoderma lucidum), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.

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Section: Fatty Acids (Fa) and Foods Rich In Fatty Acidsmentioning

confidence: 99%

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

et al. 2020

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“…Recently, Benjamin et al, (13) In prostate carcinogenesis, there are few in vitro studies. A recent one described a downregulation of the EMT pathway, mediated by calcium signaling (178), by EPA and LA, two PUFAs found in peri-prostatic adipose tissue, inversely correlated with the disease progression (149). Treatment with these two lipids resulted in a decrease of cancer cell migration, invasion and store-operated calcium entry, with a decrease of Zeb-1 expression, a key EMT transcription factor implied in prostate cancer progression (179).…”

Section: In Vitro Studiesmentioning

confidence: 99%

Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease

Fontaine

Figiel

Félix

et al. 2020

Journal of Lipid Research

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Ether lipids (ELs) are lipids characterized by the presence of either an ether linkage (alkyl lipids) or a vinyl ether linkage [i.e., plasmalogens (Pls)] at the sn1 position of the glycerol backbone, and they are enriched in PUFAs at the sn2 position. In this review, we highlight that ELs have various biological functions, act as a reservoir for second messengers (such as PUFAs) and have roles in many diseases. Some of the biological effects of ELs may be associated with their ability to regulate ion channels that control excitation-contraction/secretion/mobility coupling and therefore cell physiology. These channels are embedded in lipid membranes, and lipids can regulate their activities directly or indirectly as second messengers or by incorporating into membranes. Interestingly, ELs and EL-derived PUFAs have been reported to play a key role in several pathologies, including neurological disorders, cardiovascular diseases, and cancers. Investigations leading to a better understanding of their mechanisms of action in pathologies have opened a new field in cancer research. In summary, newly identified lipid regulators of ion channels, such as ELs and PUFAs, may represent valuable targets to improve disease diagnosis and advance the development of new therapeutic strategies for managing a range of diseases and conditions.

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“…Interestingly, SK3 is located in cholesterol-enriched membrane nanodomains, also known as lipid rafts, and its function is dependent on the lipid environment [14]. We previously identified a fatty acid (FA) profile inversely associated with PCa aggressiveness and characterized by high levels of linoleic acid (LA) and eicosapentaenoic acid (EPA) [17]. Furthermore, we highlighted that these FAs exert their protective effects through a reduction of Ca 2+ entry, involved in Zeb1 upregulation induced by TGFb, another EMT inducer [16].…”

Section: Introductionmentioning

confidence: 99%

Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression

Bery

Figiel

Kouba

et al. 2020

IJMS

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Hypoxia is a well-established feature of prostate cancer (PCa) and is associated with disease aggressiveness. The hypoxic microenvironment initiates multiple adaptive responses including epithelial-to-mesenchymal transition (EMT) and a remodeling of calcium homeostasis involved in cancer progression. In the present study, we identified a new hypoxia signaling pathway with a positive feedback loop between the EMT transcription factor Zeb1 and SK3, a Ca2+-activated K+ channel, which leads to amplifying store-operated Ca2+ entry. Zeb1 and SK3 channel were strongly upregulated by hypoxia both in vitro and ex vivo in organotypic cultures of human PCa. Taking into account the sensitivity of the SK3 channel to the membrane lipid composition, we identified lipids such as Ohmline (an alkyl ether lipid and SK3 inhibitor), linoleic acid (LA) and eicosapentaenoic acid (EPA) (fatty acids associated with indolent PCa), which were able to completely abrogate the hypoxia-induced changes in Zeb1 expression. Ultimately, better understanding of this new hypoxia-induced EMT pathway may allow to develop adjuvant therapeutic strategies, in order to control PCa aggressiveness and improve treatment outcomes.

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Fatty acid profile in peri-prostatic adipose tissue and prostate cancer aggressiveness in African–Caribbean and Caucasian patients

Cited by 28 publications

References 33 publications

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Dietary Factors and Supplements Influencing Prostate-Specific Antigen (PSA) Concentrations in Men with Prostate Cancer and Increased Cancer Risk: An Evidence Analysis Review Based on Randomized Controlled Trials

Roles of endogenous ether lipids and associated PUFAs in the regulation of ion channels and their relevance for disease

Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression

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