294 Exploring the utility of continuous glucose monitoring (CGMS) for cystic fibrosis related diabetes (CFRD)

Comparison of continuous glucose monitoring to reference standard oral glucose tolerance test for the detection of dysglycemia in cystic Fibrosis: A systematic review

“…A total of 15 studies were included in a qualitative analysis (See Table 3 ) with Dobson et al [48] evaluating correlations between CGM and both fingerpick and plasma blood glucose levels. CGM was compared to HbA1c (n = 11) [47] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] fingerpick blood glucose levels (n = 3) [48] , [59] , [60] and plasma blood glucose level (n = 2) [48] , [61] . Two studies [47] , [50] also performed OGTT alongside CGM and HbA1c.…”

“… Author Year Study Type Recruitment n Pre-existing CFRD Mean Age (yrs) CGM used HbA1c % Conclusion CGM compared to HbA1c Brennan [49] 2006 Prospective Unclear 20 10 29 Minimed NR Strong correlation between HbA1c and mean SG on CGM in CFRD R2 = 0.888 Chan* [50] 2018 Prospective Selective 93 28 14 IPro2 5.7 % HbA1c correlated with multiple glycemic measures and didn’t underestimate average SG on CGM Chan [51] 2020 Retrospective Selective 42 0 13 IPro2 5.6 % HbA1c normal despite hyperglycemia & glycemic variability on CGM in patients with NGT Elidottir [52] 2021 Prospective Consecutive 29 2 11.2 Freestyle Libre 5.4 % HbA1c significantly correlated with proportion of SG > 8 mmol/L during CGM (r(26) = 0.479, p = 0.013) and the average SG on CGM (r(26) = 0.517, p = 0.007). Hope [53] 2018 Prospective Unclear 93 Unclear 14 NS 5.7 % Strong correlation between HbA1c and average SG on CGM R = 0.86 Jackson [54] 2017 Prospective Unclear 30 0 Adults NS NR 67 % (20/30) had glycemic abnormality detected on CGM with 2/30 having abnormal HbA1c <...…”