294 A correlation between selenium and carnitine levels with hyposmotic swelling test for sperm membrane in low-grade varicocele patients

Pajovic, B Snezana; Radojević, Nemanja; Dimitrovski, Antonio; Vuković, Marko

doi:10.1016/s1569-9056(15)60291-3

Cited by 9 publications

(10 citation statements)

References 16 publications

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“…This study was consistent with the present study regarding the effect of antioxidants on male infertility resulting from varicocele [15]. It was reported in a study (2016) that selenium, along with carnitine, improved sperm parameters like motility, count, viability and normal morphology [16]. Sobhani et al (2015) examined the effects of antioxidants on sperm parameters and found a significant difference in sperm morphology between the control group and the case group, which was inconsistent with the present work [17].…”

Section: Discussionsupporting

confidence: 86%

Effects of Selenium on Various Sperm Parameters in Varicocele Rats

Monfared¹,

Khodabandehloo²,

Farzam³

2018

ME-JFM

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Aim: Varicocele is an abnormal enlargement of the pampiniform venous plexus and blood blockage in the spermatic cord. Among major effects on male fertility is oxidative stress and metabolites reflex to testicles, which in turn have a significant part in producing free radicals (reactive oxygen species =ROS). As a micronutrient, selenium has an antioxidant characteristic to normal spermatogenesis and combats oxidative stress. The present study aimed at examining selenium effects, as an antioxidant element) on sperm parameters (sperm count, motility, morphology) in varicocele rats. Methods: This study was a case-control. It was done in 2017 in the Qazvin University of Medical Sciences on 24 male Rats that were divided randomly to four 6-subject groups of control, sham, varicocele, and treated varicocele. A daily 0.2-mg selenium diet was injected intraperitoneally to the treated varicocele group. After four weeks, sperm indices were examined among all the groups and the data was analyzed by one-way ANOVA. Results: All the indices in this study (sperm count, motility and morphology) had a significant decline in the varicocele group compared to the control group (p<0.05). Results also indicated an effect of selenium as an antioxidant on the number of sperm as well as their motility. This led to improvement of these parameters having no effects on sperm morphology among varicocele rats. Conclusion: Results showed that, as an antioxidant, selenium eliminated free radicals in varicocele rats indicating its effectiveness on varicocele-dependent infertility.

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Section: Discussionsupporting

confidence: 86%

Effects of Selenium on Various Sperm Parameters in Varicocele Rats

Monfared¹,

Khodabandehloo²,

Farzam³

2018

ME-JFM

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“…The group that received the supplementation had significantly higher sperm count and motility after six months of treatment comparing to the control group. Another study on 64 variocele patients by Pajovic et al [53] focused on veryfing spermatozoa cellular membrane physical integrity using hypo-osmotic swelling test (HOS). The cells' integrity turned out to be directly proportional with selenium concentration.…”

Section: Gpx3mentioning

confidence: 99%

An impact of selected micronutrients on fertility

Żak

Leziak

Niedobylski

et al. 2020

J Educ Health Sport

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Introduction and purpose: The problem with infertility affects between 8 and 12% of reproductive-aged couples. Among the reasons, smoking, adulterated food, hormonal disorder are featured. Our purpose is to check how micronutrients impact fertility. Brief description of the state of knowledge: Micronutrients deficiency, specifically zinc and selenium deficiencies have also unpropitious impact on fertility. In this review, the potential role of these microelements in male and female reproductive health is considered. Zinc had been proved to regulate sperm motility, spermatogenesis and reduce oxidative stress. Lower delivery of selenium decrease testosterone level by causing changes in receptor of the luteinising hormone. It is also compared with lower spermatozoa concentration. In this review the role of iron, manganese, lead, nickel, copper, magnesium and cobalt is described as well. Summary: Deficiencies of some micronutrients may make worse the fertility. That's the reason why additional supplementation may be important in the treatment of infertility.

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“…Moreover, the beneficial effect of varicocelectomy on the epididymal function is reflected as an increase of epididymis-specific proteins such as alphaglucosidase along with the improvement in semen parameters (24). An intriguing point is that seminal Lcarnitine has been reported to be reduced in infertile patients with (low-grade) varicocele and normal semen parameters; the observation is meaningful as it shows that varicoceles might impair epididymal function and cause infertility even if this is not profound in conventional spermiogram, whereas LC could be used to unmask the underlying pathology and facilitate management (25). Secondly, the recent years the increased use of antioxidants as empirical treatment for several condi- tions including male infertility has given birth to a phenomenon called "antioxidant paradox", which is defined as the unresponsiveness of the body despite the administration of large doses of dietary antioxidants (26).…”

Section: Discussionmentioning

confidence: 99%

L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review

Tsampoukas

Khan

Katsouri

et al. 2020

Arch Ital Urol Androl

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Background: Varicocele has been found to impair the function of the epididymis resulting in subfertility whereas the varicocelectomy can resolve the phenomenon. L-carnitine is regarded as a biomarker for the function of the epididymis and has been found in reduced concentrations in infertile patients of various causes, including infertile men with varicocele. It seems that Lcarnitine and varicocele share clinical significance and the area of research looks promising. Objective: To identify the role of L-carnitine in the treatment of varicocele. Materials and methods: A systematic search was performed in Pubmed/Medline with the terms (L-carnitine) and (varicocele) and (L-carnitine) and (varicocelectomy). Inclusion criteria were studies reported outcomes of L-carnitine administration alone or in duet, as primary or adjuvant treatment to varicocele. Exclusion criteria were non-English language and animal studies. Studies using L-carnitine as part of a panel of therapeutic agents were avoided. Results: Only four suitable studies were identified for discussion. In one randomized study, the combination of L-carnitine and cinnoxicam improved semen parameters in patients with non-high-grade varicocele compared to L-carnitine alone and had a favourable effect on pregnancy rates but the effect of grade is unknown. In another study, as an adjuvant treatment to varicocelectomy, L-carnitine showed no clear benefit. Finally, in comparison to surgery, the results are inconclusive; two studies showed some benefit might be expected in low-grade or subclinical varicocele, but surgery appears superior. Conclusions: The evidence regarding the role of L-carnitine as a primary or adjuvant treatment of varicocele is sparse. The pathophysiological significance of L-carnitine implicates a potential role of the molecule in the management of varicocele, but the evidence so far is controversial for any recommendations. L-carnitine might be taken into consideration in selected cases; however, further search is needed in order the optimal role of L-carnitine in infertile patients with varicocele to be clarified.

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294 A correlation between selenium and carnitine levels with hyposmotic swelling test for sperm membrane in low-grade varicocele patients

Cited by 9 publications

References 16 publications

Effects of Selenium on Various Sperm Parameters in Varicocele Rats

Effects of Selenium on Various Sperm Parameters in Varicocele Rats

An impact of selected micronutrients on fertility

L-carnitine as primary or adjuvant treatment in infertile patients with varicocele. A systematic review

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