2018
DOI: 10.1245/s10434-018-6346-4
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Epirubicin and Ifosfamide with Preoperative Radiation for High-Risk Soft Tissue Sarcomas

Abstract: Treatment with preoperative radiation and pre- and post-operative epirubicin and ifosfamide was associated with favorable clinical outcomes. Survival and recurrence rates were comparable to those reported with other preoperative chemotherapy regimens in high-risk extremity sarcomas. Use of trimodality therapy should be considered for appropriate high-risk STS patients.

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Cited by 10 publications
(2 citation statements)
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“…Perioperative ChT (preferably neoadjuvant) should be considered in the context of patients with high-risk localized STS of limbs and trunkwall [II, A] [22,25,28,29]. Tumours > 5 cm, G3 and deep located have been used as high-risk population criteria.…”
Section: Management Of Local Diseasementioning
confidence: 99%
“…Perioperative ChT (preferably neoadjuvant) should be considered in the context of patients with high-risk localized STS of limbs and trunkwall [II, A] [22,25,28,29]. Tumours > 5 cm, G3 and deep located have been used as high-risk population criteria.…”
Section: Management Of Local Diseasementioning
confidence: 99%
“…En conclusión se puede afirmar que el rol de la adyuvancia es incierto y controversial, que según el metanálisis comentado en líneas anteriores las antraciclinas y la ifosfamida prolongan significativamente la supervivencia en pacientes con sarcomas de extremidades resecados, pero que resulta difícil recomendar este tratamiento en todos los casos [19][20][21][22].…”
Section: Tratamiento De Quimioterapia Adyuvanteunclassified