Cross‐sectional association between oral health and retinal microcirculation

Samietz, Stefanie; Jürgens, Clemens; Ittermann, Till; Holtfreter, Birte; Pink, Christiane; Schipf, Sabine; Biffar, Reiner; Völzke, Henry; Kocher, Thomas; Tost, Frank

doi:10.1111/jcpe.12872

Cited by 7 publications

(4 citation statements)

References 44 publications

(59 reference statements)

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“…Among participants with functional atherosclerosis, low CIMT values indicate a deficiency of the capacity to maintain the microcirculation and high CIMT values indicate more disruption of the microcirculation. Since the status of the microcirculation might be associated with oral health [ 30 ], CIMT can be associated with tooth loss only among participants without functional atherosclerosis [ Table 3 and Figure 1 b,c]. In the present study, a small but significant positive association between CIMT and CAVI was observed among participants without functional atherosclerosis [ Table 4 and Figure 1 a], but not among participants with functional atherosclerosis [ Table 4 and Figure 1 d].…”

Section: Discussionmentioning

confidence: 44%

Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study

Shimizu

Yamanashi

Kitamura

et al. 2022

JCM

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Structural arterial stiffness can be evaluated with carotid intima-media thickness (CIMT). Functional arterial stiffness can be evaluated with cardio-ankle vascular index (CAVI). A positive association between CIMT and tooth loss has been reported, but no studies have evaluated the association between CIMT and tooth loss in relation to functional arterial stiffness (functional atherosclerosis). A cross-sectional study of 1235 Japanese individuals aged 40–89 years was conducted. Tooth loss was defined as being in the lowest tertile for the number of remaining teeth (≤20 in men and ≤19 in women). Functional atherosclerosis was defined as CAVI ≥ 9.0. Independent of known confounding factors, CIMT was positively associated with tooth loss only in participants without functional atherosclerosis. Adjusted odds ratios for tooth loss and a 1 standard deviation increment in CIMT were 1.27 (1.04–1.55) for participants without functional atherosclerosis and 0.99 (0.77–1.26) for participants with functional atherosclerosis. CIMT and functional atherosclerosis had a significant effect on tooth loss; the fully adjusted p-value for the interaction on tooth loss was 0.019. Independent of known confounding factors, CIMT is positively associated with tooth loss only in participants without functional atherosclerosis. This finding helps clarify the influence of the progression of arterial stiffness on tooth loss because the progression of structural atherosclerosis might have a beneficial influence on the maintenance of the microcirculation.

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Section: Discussionmentioning

confidence: 44%

Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study

Shimizu

Yamanashi

Kitamura

et al. 2022

JCM

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“…Despite the universality of Canada's medical care system, and considerable amount of evidence on the association between oral and systemic health , publicly funded dental care remains limited and only targets specific populations in Canada. Dental care has an important role to play in the early diagnosis of oral and systemic diseases, in improving oral health and certain systemic health conditions, and in the overall quality of life . Therefore, it is arguably necessary to provide equitable access to dental care for the entire population.…”

Section: Introductionmentioning

confidence: 99%

Impact of public dental care spending and insurance coverage on utilization disparities among Canadian jurisdictions

Dehmoobadsharifabadi

Singhal

Quiñonez

2018

J Public Health Dent

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“…These results imply a possible link between periodontitis and ocular vascular disease. Indeed, a cross-sectional study showed that severe periodontitis was inversely correlated with the arteriovenous ratio, suggesting that periodontitis affects microvascular endothelium function in the retina [ 23 ]. A cohort study also demonstrated that patients with periodontitis have a higher risk of developing age-related macular degeneration than those without periodontitis [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Oral Health and Risk of Retinal Vascular Occlusions: A Nationwide Cohort Study

Kim

Jeon

Song

et al. 2023

JPM

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Retinal vascular occlusions are a common cause of visual loss. The association between oral health and the risk of retinal vascular occlusions remains unknown. We investigated whether oral health was associated with the risk of retinal vascular occlusions. We conducted a retrospective cohort study including 138,484 participants who completed a national health screening program with an oral health examination from the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) 2002–2015. Oral health markers, such as the presence of periodontitis, tooth loss, and dental caries, and the frequency of daily tooth brushing, were evaluated. The primary outcome was the occurrence of retinal vascular occlusions up to December 2015. In total, 2533 participants developed retinal vascular occlusions (215 with retinal artery occlusion, 1686 with retinal vein occlusion, 632 with unspecified retinal vascular occlusion). In the multivariable Cox regression analysis, periodontitis was an independent risk factor for retinal vascular occlusions (adjusted hazard ratio: 1.18; 95% confidence interval: 1.02–1.36; p = 0.024). Frequent tooth brushing was negatively associated with the risk of retinal vascular occlusions (adjusted hazard ratio: 0.89; 95% confidence interval: 0.80–0.98; p = 0.022). Improving oral hygiene may contribute to the attenuation of the risk of retinal vascular occlusions.

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Cross‐sectional association between oral health and retinal microcirculation

Abstract: Our results point towards an association between periodontal conditions and AVR in men. Periodontitis may impact microvascular endothelium function. Improving oral health to reduce periodontitis might lead to reduced risk for other age-related diseases.

Cited by 7 publications

References 44 publications

Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study

Tooth Loss and Carotid Intima-Media Thickness in Relation to Functional Atherosclerosis: A Cross-Sectional Study

Impact of public dental care spending and insurance coverage on utilization disparities among Canadian jurisdictions

Oral Health and Risk of Retinal Vascular Occlusions: A Nationwide Cohort Study

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