How can heart disease patients prevent complications from viral infections?

He, Ran; He, Shiping; Li, Xiaoxia; Shi, Yunfan; Liu, Qiuyun

doi:10.1177/2047487318756693

“…The human transmissibility and the long latency period of the Wuhan strains may drive the spread of the virus to other regions of world, underscoring the urgency for preventive measures. As the percentage of essential amino acids in the small orf of COVID-19 reaches 57.4%, a starch/vitamin diet served to the potentially exposed human subpopulation for short period of time does not give rise to essential amino acids such as isoleucine and lysine and reduces the viral load, which could be adopted as prophylactic approach of COVID-19 (Gan et al, 2018;Wan et al, 2019;He et al, 2018;Wahl et al, 2018). Peptides consisting of essential amino acids are often stressful (Tang et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

Wan¹,

Yan²,

Zhang³

et al. 2020

Preprint

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The current pneumonia epidemic in China could evolve into a pandemic on a global scale if not effectively contained. The COVID-19 possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in COVID-19. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. As the content of essential amino acids in the open reading frame of COVID-19 reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Furthermore, several proteins of COVID-19 possess high valine plus glycine content which is implicated in heart disease, justifying the aforementioned approaches.

show abstract

“…The human transmissibility and the long latency period of the Wuhan strains may drive the spread of the virus to other regions of world, underscoring the urgency for preventive measures. As the percentage of essential amino acids in the small orf of 2019-nCoV reaches 57.4%, a starch/vitamin diet served to the potentially exposed human subpopulation for short period of time does not give rise to essential amino acids such as isoleucine and lysine and reduces the viral load, which could be adopted as prophylactic approach of 2019-nCoV (Gan et al, 2018;Wan et al, 2019;He et al, 2018;Wahl et al, 2018). Peptides consisting of essential amino acids are often stressful (Tang et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus

Y¹,

Yan²,

Zhang³

et al. 2020

Preprint

Self Cite

0

View full text Add to dashboard Cite

The current pneumonia epidemic in China could evolve into a pandemic on a global scale if not effectively contained. The 2019-nCoV possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in 2019-nCoV. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. As the content of essential amino acids in the open reading frame of 2019-nCoV reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. Furthermore, several proteins of 2019-nCoV possess high valine plus glycine content, which is implicated in heart disease.

show abstract

“…The human transmissibility and the long latency period of the Wuhan strains may drive the spread of the virus to other regions of world, underscoring the urgency for preventive measures. As the percentage of essential amino acids in the small orf of 2019-nCoV reaches 57.4%, a starch/vitamin diet served to the potentially exposed human subpopulation for short period of time does not give rise to essential amino acids such as isoleucine and lysine and reduces the viral load, which could be adopted as prophylactic approach of 2019-nCoV (Gan et al, 2018;Wan et al, 2019;He et al, 2018;Wahl et al, 2018). Peptides consisting of essential amino acids are often stressful (Tang et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus

Yan¹,

Wan²,

Zhang³

et al. 2020

Preprint

Self Cite

0

View full text Add to dashboard Cite

The current pneumonia epidemic in China could evolve into a pandemic on a global scale if not effectively contained. The 2019-nCoV possesses a 61-amino acid open reading frame resembling SARS-CoV virulence factor - ORF6 peptide. The isoleucine content is 15.9% in ORF6 of SARS-CoV versus 16.4% of that in 2019-nCoV. Given the proton affinity in the carbonyl oxygen in isoleucine, augmented proton traffic can enhance proton-ion antiport and prompt cell swelling. As the content of essential amino acids in the open reading frame of 2019-nCoV reaches 57.4%, a starch/vitamin diet served for short period of time does not give rise to essential amino acids and halts virion production, which could be adopted as prophylactic approach of many viral infections. Plant-based diet or fasting/boiled rice water can also minimize the intake of essential amino acids or all amino acids respectively. Calorie restriction has been confirmed in animal studies to extend lifespan, and its underlying mechanism is not fully known. Furthermore, several proteins of 2019-nCoV possess high valine plus glycine content, which is implicated in heart disease.

show abstract

How can heart disease patients prevent complications from viral infections?

Cited by 13 publications

References 4 publications

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

The Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of COVID-19 Virus

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus

The Wuhan Pneumonia Outbreak: High Isoleucine and High Valine Plus Glycine Contents Are Features of the Proteins of 2019-nCoV Virus

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