Optical clearing agent reduces scattering of light by the stratum corneum and modulates the physical properties of coenocytes via hydration

Lee, S.‐H.; Jun, Seung-Hyun; Yeom, Junseok; Park, S.‐G.; Lee, C.‐K.; Kang, Nam Lyong

doi:10.1111/srt.12439

Cited by 7 publications

(2 citation statements)

References 20 publications

(36 reference statements)

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“…Besides its functional role, the skin is an important element in social life; thus, various approaches are being tried to have beautiful and healthy skin. The most important part of the skin is the stratum corneum, which is the outermost layer of the skin . The problem in the stratum corneum is closely related not only to appearance but also to skin diseases such as dryness, acne, and psoriasis …”

Section: Introductionmentioning

confidence: 99%

Identification and validation of amino acid‐based mild exfoliating agents through a de novo screening method

Ahn¹,

Lee

Kim³

et al. 2019

J of Cosmetic Dermatology

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Background: Due to internal or external factors, the desquamation (turnover) rate of the stratum corneum slows down, resulting in skin problems. Therefore, adjusting the exfoliation rate through cosmetics is an important issue.Objective: This report aimed to develop exfoliating agents with lesser adverse effects and higher efficiency through an ex vivo screening method and in vivo turnover rate analysis of human skin.Methods: Various molecules were evaluated by the ex vivo porcine skin exfoliation method and screened for their potential as effective agents. To confirm the effect and mechanism of each agent found, the exfoliation efficiency was evaluated. Each agent was also applied to the actual human skin to determine its efficacy and side effects.Results: Despite the pH 6, carnitine and serine, which have similar or better efficiency compared to PHA, were selected. Based on the results, it was confirmed that calcium. And it is nonirritating to the human skin and increases the turnover rate (~130%). Conclusion:Amino acid-based exfoliating agents, such as carnitine and serine, were identified and verified to enhance the rate of exfoliation of the stratum corneum. It is expected that the improvement of dullness, mild acne, fine wrinkles, and pores through skin exfoliation in the field of cosmetics can be achieved safely through these agents. K E Y W O R D Samino acids, chemical peel, cosmetics, desquamation, exfoliating agent, stratum corneum

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Section: Introductionmentioning

confidence: 99%

Identification and validation of amino acid‐based mild exfoliating agents through a de novo screening method

Ahn¹,

Lee

Kim³

et al. 2019

J of Cosmetic Dermatology

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“…F I G U R E 1 Analysis of keratin stiffness in stratum corneum using ATR-FTIR spectroscopy 16 : (A) Stiffness changes according to the structural change of the keratin protein constituting the stratum corneum; (B) occlusive or humectant inhibits the evaporation of water from the inside of the skin; and (C) structural changes that occur by penetrating into the excised stratum corneum are observed. is insufficient, the ratio of alpha-helix increases, and stiffness also increases.…”

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confidence: 99%

Arginine–fructose–glucose from red ginseng extract reduces stiffness of keratin fiber in corneocyte of skin

Kim

Lee

2022

Skin Research and Technology

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Purpose:The moisture content of the stratum corneum of the skin changes depending on the external environment. The structure of keratinous fiber protein in corneocyte of the skin changes depending on the amount of moisture. As the moisture decreases, the population of the alpha-helix increases, the beta-sheet deceases, and the stiffness increases accordingly. Here, we investigated the effect of humectants from ginseng on the keratin structure.Methods: Corneocyte was prepared from dry porcine skin with disc tape and measured through ATR-FT-IR. The signal from amide I of the keratin protein in corneocyte was detected, and the change in the ratio of alpha-helix and beta-sheet was calculated. The test samples were treated on the exfoliated corneocyte, and the degree of change was checked.Result: Arginine-fructose-glucose (AFG)-enriched extract of red ginseng was effective in changing the keratin structure and was superior to humectants such as glycerin.However, arginine, mono sugar were not effective, and the AFG form in which two sugars were bound to one amino acid could perform its function. Conclusion:The present study suggests that AFG, when applied to cosmetics, is expected to improve skin texture in a different way from existing moisturizers represented by glycerin by reducing the alpha-helix structure of corneocyte keratin.

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A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

et al. 2016

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The roots of two peony species, Paeonia lactiflora Pallas and Paeonia veitchii Lynch are routinely referred to as either chishao () or baishao (). This paper reviews the botanical origins and traditional medicinal usage of each species, as well as pharmacological like activity of their constituents. A search of herbal pharmacological encyclopaedia, PubChem and PubMed databases identified their known constituents. The biological data for these constituents were evaluated and classified according to pharmacological-like activity, with emphasis on compounds of greatest concentration and bioavailability. It was found that P. lactiflora and P. veitchii have some common compounds; however, their phytochemical bioavailability varies. Furthermore, a larger number of compounds have been identified in P. lactiflora. These have greater potential for antiinflammatory, antiviral, antibacterial and antioxidant therapeutic activity compared with P. veitchii. However, evidence indicates both species are similarly indicated for antiviral and glycaemic activity. Major compounds of each are classified as flavonoids, hydrolysable tannins (polyphenols) and monoterpene glycosides. The evidence suggests both species, when administered in entire botanical form, have an excellent safety profile; however, constituent toxicity risk evidence is limited, requiring further investigation. Although experiments show many compounds have biological activity, further investigation of their therapeutic potential is needed. Copyright © 2016 John Wiley & Sons, Ltd.

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Optical clearing agent reduces scattering of light by the stratum corneum and modulates the physical properties of coenocytes via hydration

Cited by 7 publications

References 20 publications

Identification and validation of amino acid‐based mild exfoliating agents through a de novo screening method

Identification and validation of amino acid‐based mild exfoliating agents through a de novo screening method

Arginine–fructose–glucose from red ginseng extract reduces stiffness of keratin fiber in corneocyte of skin

A Pharmacological Review of Bioactive Constituents ofPaeonia lactifloraPallas andPaeonia veitchiiLynch

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