Relation between aortic knob width and subclinical left ventricular dysfunction in hypertensive patients

Gürbak, İsmail; Yıldız, İbrahim; Panç, Cafer

doi:10.1080/10641963.2017.1411496

Cited by 4 publications

(8 citation statements)

References 13 publications

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“…Gurbak et al sought to determine whether AKW has a predictive value to detect subclinical left ventricular function in patients with known hypertension. The authors reported that AKW ( β = 0.617, P = 0.001) and posterior wall thickness ( β = 1.189, P = 0.021) were independently associated with subclinical left ventricular dysfunction.…”

Section: Discussionmentioning

confidence: 99%

“…It not only represents the extent of aortic dilatation, but it may also indicate aortic atherosclerosis or tortuosity. There have been several studies suggesting a positive correlation with increased AKW and presence of coronary atherosclerosis, left ventricular dysfunction, metabolic syndrome and arrhythmias . Although the association of both OSA and AKW with cardiovascular diseases has been demonstrated, there is no study showing whether AKW has an association with OSA and whether AKW can be used as a marker of OSA.…”

Section: Introductionmentioning

confidence: 99%

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The association between aortic knob width on chest x‐ray and obstructive sleep apnoea syndrome in patients referred for sleep testing

Çetin

Casim

2019

Clinical Respiratory J

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Objective: Obstructive sleep apnoea (OSA) has been linked with many forms of cardiovascular diseases. Aortic knob width (AKW) has increasingly been presented as a marker of diagnosis and prognosis of atherosclerotic coronary artery disease. We sought to determine whether AKW has an association with sleep apnoea syndrome in patients referred to sleep testing in order to provide baseline information for future studies on general population. Methods: A total of 363 patients were included in this retrospective study. The capacity of AKW indexed by patients' height in predicting the presence of severe OSA was analysed using receiver operating characteristics curve analysis. The association of OSA severity with AKW indexed by height was tested with two separate models of ANCOVA (analysis of variance). Results: Area under the curve for estimating severe OSA with AKW was 0.67 (95% CI, 0.60 to 0.73, P < 0.001). A cut-off value of 21.42 mm/m provided a sensitivity of 62.6% and a specificity of 70.7% for severe OSA. In both ANCOVA models, the association of OSA severity on AKW indexed by height was significant and the effect size was moderate (P < 0.001, partial eta squared: 0.09 and 0.05). Conclusions: Aortic knob width indexed by height has a significant association with the severity of OSA; however, the association is significantly influenced by gender and age. K E Y W O R D Saortic knob width, apnoea-hypopnea index, chest, obstructive sleep apnoea

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The association between aortic knob width on chest x‐ray and obstructive sleep apnoea syndrome in patients referred for sleep testing

Çetin

Casim

2019

Clinical Respiratory J

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“…[ 22 ] Rayner et al found that the cardiothoracic ratio and AKW which of both can be measured on the chest radiography, were significant predictors of target organ damage. [ 23 ] In the study of Gürbak et al, [ 9 ] the relationship between AKW and left ventricular hypertrophy was evaluated in hypertensive patients, and AKW was found to be an essential indicator of subclinical left ventricular hypertrophy. ROC curve analysis demonstrated that aortic knob of 37 mm constitutes the cutoff value for the presence of subclinical LV dysfunction with 85.9% sensitivity and 86.4% specificity.…”

Section: Discussionmentioning

confidence: 99%

“…The close relationship between AKW and cardiovascular disease in hypertensive patients has been shown in many studies. [ 6 – 9 ] However, it is not clear whether there is a direct relationship between AKW and RI or not.…”

Section: Introductionmentioning

confidence: 99%

Renal resistive index and aortic knob width relationship as a predictor of renal prognosis in essential hypertension

Sevencan

Ozkan²

2018

Medicine

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The scientific studies that have been conducted so far highlight that renal resistive index (RI) and aortic knob width (AKW) indicate poor prognosis regarding renal and cardiovascular mortality. But the existence of a direct relationship RI and AKW is unclear. This study aims investigating the relationship between RI and the measured AKW in chest radiography of the patients with hypertensive nephropathy who do not require renal replacement therapy.This prospective study included 268 consecutive patients with essential hypertension. Patients were divided into 2 groups as RI ≥0.7 and RI <0.7. The ROC curve, sensitivity, and specificity ratios were evaluated to determine which AKW value is the best predictive one for the RI ≥0.7.The cutoff point of AKW was evaluated as ≥36 for the cases with RI ≥0.7: sensitivity was 71.22%; specificity was 71.32%; the positive predictive value (PPV) was 72.79; the negative predictive value (NPV) was 69.70, and the accuracy was 71.27. Area under the ROC curve ± standard error (AUC ± SE) = 0.729 ± 0.031 (P < .001).AKW can provide important predictive information about the subclinical renal dysfunction in hypertensive patients with RI ≥0.7. Moreover; AKW is a predictive factor for both the diagnostic and prognostic evaluation of renal pathologies.

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“…Aortic knob width (AKW) represents a measurement of the aortic arch and upper part of the descending aorta assessed in X-ray of the chest. Many studies of hypertensive patients showed intimate relation between AKW and cardiovascular diseases (3,4) . As AKW was found to be increased with age and atherosclerosis, so it was suggested to be a major predictor of organ damage occurring in hypertension (5) .…”

Section: Introductionmentioning

confidence: 99%

Renal Resistive Index as An Indicator of Atherosclerotic Changes and Renal Damage in Hypertension and Its Role in Therapeutic Intervention

Elshimy¹,

Shimy²,

Michael³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Renal resistive index (RRI) was suggested as an indicator of renal atherosclerotic changes in hypertensive patients with possible prognostic role in treatment.Objectives: This study aimed to assess RRI in hypertensive subjects, its relation to other predictors of target organ damage and prognostic usefulness in management, specifically, with different antihypertensive drugs. Patients and methods:The study included 100 newly diagnosed hypertensive adult subjects, who underwent abdominal ultrasound with Doppler to assess RRI, which was correlated with their clinical parameters including estimated glomerular filtration rate (eGFR) and other subclinical atherosclerosis markers as carotid intima-media thickness (IMT) and aortic knob width (AKW) calculated from chest radiograph. Another 50 non hypertensive subjects were assessed for their RRI as a control group. In addition, some of hypertensive patients were followed up one year after starting treatment was done and effects of different antihypertensive agents on their RRI were compared. Results:The mean baseline RRI in hypertensive patients (0.71 ± 0.04) was significantly higher compared to control group (0.60 ± 0.02) and was positively significantly correlated with their clinical parameters (age, systolic, diastolic, pulse pressure and eGFR) and with their atherosclerotic parameters (IMT and AKW). In addition, ACE/ARBs treatment was associated with significant decrease of RRI compared to other drugs [beta blocker (BB) and calcium channel blocker (CCB)], indicating their more renal protective effect. Conclusion: Assessment of RRI in patients with primary hypertension not only reflecting intrarenal perfusion changes, but it indicates systemic atherosclerotic changes, so it can be useful as prognostic parameter in addition to its possible therapeutic implications.

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Relation between aortic knob width and subclinical left ventricular dysfunction in hypertensive patients

Abstract: AKW may provide important predictive information on subclinical LV dysfunction in patients with hypertension.

Cited by 4 publications

References 13 publications

The association between aortic knob width on chest x‐ray and obstructive sleep apnoea syndrome in patients referred for sleep testing

The association between aortic knob width on chest x‐ray and obstructive sleep apnoea syndrome in patients referred for sleep testing

Renal resistive index and aortic knob width relationship as a predictor of renal prognosis in essential hypertension

Renal Resistive Index as An Indicator of Atherosclerotic Changes and Renal Damage in Hypertension and Its Role in Therapeutic Intervention

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