Association between bacteria occurring in the apical canal system and expression of bone‐resorbing mediators and matrix metalloproteinases in apical periodontitis

Takahama, Ademar; Rôças, Isabela N.; Faustino, Isabel Schausltz Pereira; Alves, Flávio R.F.; Azevedo, Rebeca Souza; Gomes, Cinthya Cristina; Araújo‐Filho, W. R.; Siqueira, José F.

doi:10.1111/iej.12895

Cited by 32 publications

(38 citation statements)

References 53 publications

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“…There is a clear evidence that microbial interaction plays an important role for the pathogenesis of AP [25,26]. Microorganisms may cause direct tissue damage and modulate the immunological response by secretion of products, including enzymes, exotoxins and metabolic end-products [27][28][29]. Based on the variation in root-canal infection with different virulence factors, the immunological response causing AP will vary over time.…”

Section: Infection and Inflammatory Responsementioning

confidence: 99%

Inflammatory profile of chronic apical periodontitis: a literature review

Braz‐Silva

Bergamini

Mardegan

et al. 2018

Acta Odontologica Scandinavica

149

129

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Apical periodontitis caused by root canal infection is the most frequent pathological lesion in the jaws, mainly manifested as periapical granulomas and cysts. Understanding of the formation and progression of apical periodontitis as well as the identification of inflammatory biomarkers can help increase the knowledge of pathogenic mechanisms, improve the diagnosis and provide support for different therapeutic strategies. The objective of the present article is to review inflammatory biomarkers such as cytokines, chemokines, inflammatory cells, neuropeptides, RANK/RANKL/OPG system and other inflammatory markers and to relate these systems to the development and progression of pathological conditions related to apical periodontitis.

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Section: Infection and Inflammatory Responsementioning

confidence: 99%

Inflammatory profile of chronic apical periodontitis: a literature review

Braz‐Silva

Bergamini

Mardegan

et al. 2018

Acta Odontologica Scandinavica

149

129

View full text Add to dashboard Cite

show abstract

“…Studies examining the microflora in traumatic injuries using these methodologies are underway, 48 as this area has not been sufficiently explored. 53 In this study, it was found that increased matrix metalloproteinase-2 and −9, receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and decreased osteoprotegerin were correlated with the phylum Actinobacteria, which contains the genus Actinomyces (53%) and the genus Streptococcus (35%). 49 This was an important finding because this microorganism commonly forms periapical microbial colonies that persist despite nonsurgical root canal treatment.…”

Section: Crob I Ology Of Tr Auma-rel Ated Endodonti C Infec Ti On Smentioning

confidence: 75%

“…[50][51][52] In addition, a comprehensive analysis of bacteria in the apical third of infected root canals and their correlation with bone-resorbing inflammatory mediators and matrix metalloproteinases was recently reported. 53 In this study, it was found that increased matrix metalloproteinase-2 and −9, receptor activator of nuclear factor kappa B, receptor activator of nuclear factor kappa B ligand, and decreased osteoprotegerin were correlated with the phylum Actinobacteria, which contains the genus Actinomyces (53%) and the genus Streptococcus (35%).…”

Section: Fouadmentioning

confidence: 75%

Microbiological aspects of traumatic injuries

Fouad

2019

Dental Traumatology

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After traumatic injuries to teeth, microorganisms may invade the compromised pulp tissue and initiate pulp infection and periapical inflammation. In addition to bone resorption that typically accompanies pulp necrosis, root resorption frequently occurs.Root resorption has several variants that may occur shortly after the trauma or at a later stage. The pathological changes seen after traumatic injuries to teeth are invariably linked to the presence of microbial irritants. The presence of bacterial biofilms in the dental pulp space can be treated with regenerative or therapeutic endodontic procedures. However, necrosis of periodontal ligament is usually terminal for the tooth involved. In this review, the sources of bacteria after traumatic injuries are discussed. The types and role of microorganisms involved in the pathogenesis of endodontic pathosis after traumatic injuries are presented, and contemporary approaches for the management of these conditions are reviewed. Contemporary antimicrobial strategies are discussed. The rationale for the use of systemic and topical antimicrobials is presented. Finally, novel approaches to the use of antimicrobial therapies, particularly in regenerative procedures, are reviewed.

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“…Since dental caries and severe periodontitis contribute to most cases of tooth loss, it is important to study the histopathological features of both cementum and pulp in cases of severe periodontitis. Pathological changes in teeth (including cementum and dental pulp) with chronic periapical periodontitis have been reported earlier and their interrelationship had been clearly verified . ‒ However, the interrelationship between severe chronic periodontitis and histopathological conditions of the pulp/cementum is seldom reported and, if at all, is mainly focused on the histological features …”

Section: Introductionmentioning

confidence: 99%

“…Pathological changes in teeth (including cementum and dental pulp) with chronic periapical periodontitis have been reported earlier and their interrelationship had been clearly verified. [5][6][7] However, the interrelationship between severe chronic periodontitis and histopathological conditions of the pulp/cementum is seldom reported and, if at all, is mainly focused on the histological features. 8,9 Studies on the impact of periodontitis on dental pulp have been contradictory, possibly because of the lack of explicit inclusion and exclusion criteria for clinical cases, and lack of systemic records of patients.…”

Section: Introductionmentioning

confidence: 99%

Severe periodontitis may influence cementum and dental pulp through inflammation, oxidative stress, and apoptosis

et al. 2019

Journal of Periodontology

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Background The relationship between chronic periodontitis and pulpal/cemental changes is seldom reported. This study aimed to report on the microstructural changes of cementum and histopathological features of the dental pulp in teeth with severe chronic periodontitis. Methods Eighty molar teeth with severe chronic periodontitis and 50 extracted third molars (as normal controls) were collected. The microstructure of cementum was evaluated by scanning electron microscopy, and the pulp was stained with hematoxylin and eosin. Interleukin (IL)‐17 and IL‐1β levels were examined by immunohistochemistry/western blotting. Reactive oxygen species (ROS) and superoxide dismutase 1 (SOD 1) levels were also checked. Caspase 3 expression and terminal‐deoxynucleotidyl transferase dUTP nick‐end labeling (TUNEL) staining were used as apoptotic indices, and LC3B and P62 were detected to demonstrate the level of autophagy. Results The surface of cementum showed irregularities; the dental pulp was inflamed and under oxidative stress. IL‐17 and IL‐1β levels were increased in the pulp of teeth with periodontitis. ROS and apoptosis levels were higher than in normal dental pulp, while SOD 1 level was reduced. Intriguingly, autophagy markers LC3B and P62 were upregulated in the pulp obtained from teeth with periodontitis. Conclusions Severe chronic periodontitis influenced the microstructure of both cementum and dental pulp. The dental pulp collected from teeth with periodontitis was inflamed, under oxidative stress, and presented increased levels of apoptosis and autophagy relative to normal dental pulp.

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Association between bacteria occurring in the apical canal system and expression of bone‐resorbing mediators and matrix metalloproteinases in apical periodontitis

Abstract: Actinobacteria may play an important role in the active phase of soft and bone tissue destruction in apical periodontitis.

Cited by 32 publications

References 53 publications

Inflammatory profile of chronic apical periodontitis: a literature review

Inflammatory profile of chronic apical periodontitis: a literature review

Microbiological aspects of traumatic injuries

Severe periodontitis may influence cementum and dental pulp through inflammation, oxidative stress, and apoptosis

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