Association of Hyperthyroidism and Thyroid Autoantibodies with Moyamoya Disease and Its Stroke Event: A Population-based Case-control Study and Meta-analysis

Ahn, Jun Hyong; Jeon, Jin Pyeong; Kim, Jeong Eun; Ha, Eun Jin; Cho, Won Sang; Park, Young Joo; Cho, Nam Han; Choi, Hoon; Kang, Hyun Seung; Son, Young Hoon; Bang, Jae Seung; Oh, Chang Wan

doi:10.2176/nmc.oa.2017-0198

Cited by 13 publications

(16 citation statements)

References 31 publications

(54 reference statements)

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“…HLA-DRB1*04 : 10 -positive patients account for ~10% of Japanese MMD patients; therefore, its involvement should be investigated in a larger population or other institutions. In addition, association between thyroid dysfunction and MMD is different between Asians and Caucasians: GD is more prevalent among Japanese MMD patients, whereas HT is more prevalent among Caucasian MMD patients [5–10]. The patients and controls in this study were residents of Tohoku and Kanto districts.…”

Section: Discussionmentioning

confidence: 99%

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Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

et al. 2019

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Background and purpose Moyamoya disease (MMD) is a progressive cerebrovascular disease with unknown etiology. Growing evidence suggest its involvement of autoimmune and genetic mechanisms in the pathogenesis of MMD. This study aims to clarify the association between HLA allele and MMD. Methods Case-control study: the DNA of 136 MMD patients in Japan was extracted and the genotype of human leukocyte antigen ( HLA ) from this DNA was determined by super-high-resolution single-molecule sequence-based typing using next-generation sequencing. Next, the frequency of each HLA allele ( HLA-A , HLA-B , HLA-C , HLA-DRB1 , HLA-DQB1 , and HLA-DPB1 ) was compared with those in the Japanese control database. In addition, haplotype estimation was performed using the expectation maximization algorithm. Results The frequencies of the HLA-DRB1*04 : 10 allele (4.77% vs. 1.47% in the control group; P = 1.7 × 10 −3 ; odds ratio [OR] = 3.35) and of the HLA-DRB1*04 : 10–HLA-DQB1*04 : 02 haplotype (haplotype frequency 4.41% vs. 1.35% in the control group; P = 2.0 × 10 −3 ; OR = 3.37) significantly increased. The frequency of thyroid diseases, such as Graves’ disease and Hashimoto thyroiditis, increased in HLA-DRB1*04 : 10 -positive MMD patients compared with that in HLA-DRB1*04 : 10 -negative MMD patients. Conclusions HLA-DRB1*04 : 10 is a risk allele and HLA-DRB1*04 : 10–HLA-DQB1*04 : 02 a risk haplotype for MMD. In addition, HLA-DRB1*04 : 10 is associated with thyroid disease in MMD patients.

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Section: Discussionmentioning

confidence: 99%

“…Thus, it is expected to unveil the pathogenesis of MMD and diagnose MMD before onset of stroke. Although the etiology of MMD remains undetermined, previous studies showed an association between autoimmunity and MMD [4–11], such as the high frequencies of thyroid dysfunction and type 1 diabetes among MMD patients [4–10].…”

Section: Introductionmentioning

confidence: 99%

Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

et al. 2019

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“… 10 Thyrotoxicosis will also aggravate the ischemic situation in MMD. 11 The underlying reason for this is unknown, but several pathological mechanisms have been proposed. First, thyrotoxicosis tends to induce hypermetabolism and increases oxygen consumption in the brain.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with MMD but without GD, elevation of thyroid autoantibodies is frequently encountered; additionally, thyrotoxicosis can worsen the ischemic condition of MMD. 10 , 11 This indicates a complicated interaction between GD and MMD.…”

Section: Introductionmentioning

confidence: 99%

Aneurysmal bone cyst of the proximal femur concomitant with Graves’ disease and Moyamoya disease: report of a rare case

2022

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Aneurysmal bone cyst is a type of benign bone pathology with expansile and osteolytic features whose etiology remains unclear. Graves’ disease is an autoimmune disease characterized by diffuse goiter and hyperthyroidism. Moyamoya disease is a progressive cerebral vasculopathy. It has been reported that Graves’ disease and Moyamoya disease share a similar etiology involving cytokines and autoimmune and genetic factors. There are no previous reports regarding the relationship between aneurysmal bone cyst and Graves’ disease. Here, we present the rare case of a 25-year-old woman with suspected aneurysmal bone cyst of the left proximal femur and a definite preoperative diagnosis of Graves’ disease, in whom lesion resection combined with left total hip replacement was indicated. Biopsy confirmed the diagnosis of aneurysmal bone cyst. Three days postoperatively, the patient developed acute ischemic cerebral infarction owing to Moyamoya disease, which was subsequently confirmed. This case elucidates the potential interaction among aneurysmal bone cysts, Graves’ disease, and Moyamoya disease and provides lessons regarding appropriate perioperative preparation for patients with Graves’ disease who require surgery to avoid potential severe complications.

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“…The relationship between specific thyroid condition and moyamoya disease has been reported for some time, and it has also been reported to be related to clinical manifestation. Specifically, hyperthyroidism and elevated anti-thyroperoxidase antibody are likely to be associated with ischemic stroke in adult moyamoya disease [30].…”

Section: Clinical Factors Associated With Ischemic Onset Moyamoya Diseasementioning

confidence: 99%

Differences in Clinical Features among Different Onset Patterns in Moyamoya Disease

Hirano

Miyawaki

Imai

et al. 2021

JCM

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Moyamoya disease is characterized by severe stenosis at the ends of the bilateral internal carotid arteries and the development of collateral circulation. The disease is very diverse in terms of age at onset, onset patterns, radiological findings, and genetic phenotypes. The pattern of onset is mainly divided into ischemic and hemorrhagic onsets. Recently, the opportunity to identify asymptomatic moyamoya disease, which sometimes manifests as nonspecific symptoms such as headache and dizziness, through screening with magnetic resonance imaging has been increasing. Various recent reports have investigated the associations between the clinical features of different onset patterns of moyamoya disease and the corresponding imaging characteristics. In this article, we have reviewed the natural history, clinical features, and imaging features of each onset pattern of moyamoya disease.

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Association of Hyperthyroidism and Thyroid Autoantibodies with Moyamoya Disease and Its Stroke Event: A Population-based Case-control Study and Meta-analysis

Cited by 13 publications

References 31 publications

Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its association with autoimmune thyroid disease: A case-control study

Aneurysmal bone cyst of the proximal femur concomitant with Graves’ disease and Moyamoya disease: report of a rare case

Differences in Clinical Features among Different Onset Patterns in Moyamoya Disease

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