Living with chronic pain: perceptions of breast cancer survivors

Bao, Ting; Seidman, Andrew D.; Li, Qing; Seluzicki, Christina; Blinder, Victoria S.; Meghani, Salimah H.; Farrar, John T.; Mao, Jun J.

doi:10.1007/s10549-018-4670-9

Cited by 24 publications

(15 citation statements)

References 30 publications

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“…Musculoskeletal pain was the most common indication associated with concomitant oral analgesics in our analysis. This is consistent with previous reports by Fenlon et al [23] and Bao et al [26], which also found high rates of musculoskeletal pain in patients with breast cancer following surgery but before adjuvant therapy and in breast cancer survivors with current or prior use of aromatase inhibitors.…”

Section: Discussionsupporting

confidence: 93%

Oral Analgesic Use in Postmenopausal Women After Curative Breast Cancer Treatment: Post Hoc Analysis of the ATAC Trial

Datto

Johansen

Leon‐Casasola

2020

Breast Cancer Manag.

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Aim: To evaluate analgesic use and associated conditions in postmenopausal women who had undergone curative breast cancer treatment. Materials & methods: This post hoc analysis used the Arimidex, Tamoxifen, Alone or in Combination (ATAC) trial database, which included patient reports of concomitant medications and associated indications during follow-up. Results: Of 3434 women with eligible concomitant medication data, 71.8% reported oral analgesic use. Of 2321 patients using analgesics ≥30 days, 47.9% reported opioid use. Musculoskeletal pain was the most common indication for oral analgesic use. Of patients using opioids, 28.1% reported concomitant laxative use. Conclusion: Approximately half of the patients reported opioid use, most commonly for noncancer (musculoskeletal) pain, suggesting that breast cancer survivors experience chronic pain that should be appropriately managed.

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Section: Discussionsupporting

confidence: 93%

Oral Analgesic Use in Postmenopausal Women After Curative Breast Cancer Treatment: Post Hoc Analysis of the ATAC Trial

Datto

Johansen

Leon‐Casasola

2020

Breast Cancer Manag.

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“…Individual characteristics (eg, age, income) and clinical factors (eg, cancer stage, time since diagnosis) contribute to survivors' QOL . A common complaint, chronic pain, is reported by up to 78% of survivors, and thought to be related to poor QOL outcomes . This highlights a need to expand access to evidence‐based QOL management tools that are capable of supporting a wide range of individual needs.…”

Section: Introductionmentioning

confidence: 99%

Quality of life among women diagnosed with breast Cancer: A randomized waitlist controlled trial of commercially available mobile app‐delivered mindfulness training

et al. 2018

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“…Intense pain during the first hours or days following surgery has been shown to be strongly associated with the emergence of persistent pain, defined as the presence of pain three or more months after surgery (Feizerfan & Sheh, 2015; Schneiderhan, Clauw, & Schwenk, 2017). In addition, for oncological patients undergoing a psychologically vulnerable period shortly after the diagnosis of breast cancer, avoidance of acute pain is central (Bao et al., 2018; Peuckmann et al., 2009).…”

Section: Introductionmentioning

confidence: 99%

Preventing pain after breast surgery: A systematic review with meta‐analyses and trial‐sequential analyses

Lepot

Elia

Tramèr

et al. 2020

European Journal of Pain

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Background and objective: The aim of this systematic review was to indirectly compare the efficacy of any intervention, administered perioperatively, on acute and persistent pain after breast surgery. Databases and data treatment: We searched for randomized trials comparing analgesic interventions with placebo or no treatment in patients undergoing breast surgery under general anaesthesia. Primary outcome was intensity of acute pain (up to 6 hr postoperatively). Secondary outcomes were cumulative 24-hr morphine consumption, incidence of postoperative nausea and vomiting (PONV), and chronic pain. We used an original three-step approach. First, meta-analyses were performed when data from at least three trials could be combined; secondly, trial sequential analyses were used to separate conclusive from unclear evidence. And thirdly, the quality of evidence was rated with GRADE. Results: Seventy-three trials (5,512 patients) tested loco-regional blocks (paravertebral, pectoralis), local anaesthetic infiltrations, oral gabapentinoids or intravenous administration of glucocorticoids, lidocaine, N-methyl-D-aspartate antagonists or alpha2 agonists. With paravertebral blocks, pectoralis blocks and glucocorticoids, there was conclusive evidence of a clinically relevant reduction in acute pain (visual analogue scale > 1.0 cm). With pectoralis blocks, and gabapentinoids, there was conclusive evidence of a reduction in the cumulative 24-hr morphine consumption (> 30%). With paravertebral blocks and glucocorticoids, there was conclusive evidence of a relative reduction in the incidence of PONV of 70%. For chronic pain, insufficient data were available. Conclusions: Mainly with loco-regional blocks, there is conclusive evidence of a reduction in acute pain intensity, morphine consumption and PONV incidence after breast surgery. For rational decision making, data on chronic pain are needed. Significance: This quantitative systematic review compares eight interventions, published across 73 trials, to prevent pain after breast surgery, and grades their degree of efficacy. The most efficient interventions are paravertebral blocks, pectoralis blocks and glucocorticoids, with moderate to low evidence for the blocks. Intravenous lidocaine and alpha2 agonists are efficacious to a lesser extent, but with a higher level of evidence. Data for chronic pain are lacking.

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Living with chronic pain: perceptions of breast cancer survivors

Abstract: One in three postmenopausal, HR+ BCS considered themselves to be living with chronic pain. Effective interventions to reduce chronic pain are needed.

Cited by 24 publications

References 30 publications

Oral Analgesic Use in Postmenopausal Women After Curative Breast Cancer Treatment: Post Hoc Analysis of the ATAC Trial

Oral Analgesic Use in Postmenopausal Women After Curative Breast Cancer Treatment: Post Hoc Analysis of the ATAC Trial

Quality of life among women diagnosed with breast Cancer: A randomized waitlist controlled trial of commercially available mobile app‐delivered mindfulness training

Preventing pain after breast surgery: A systematic review with meta‐analyses and trial‐sequential analyses

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