Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease

Savchenko, Ekaterina; Marote, Ana; Russ, Kaspar; Collin, Anna; Goldwurm, Stefano; Roybon, Laurent; Pomeshchik, Yuriy

doi:10.1016/j.scr.2018.01.002

Cited by 3 publications

References 2 publications

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Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

Yousefi

Abdollahii

Kouhbanani

et al. 2020

Journal Cellular Physiology

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Based on investigations, there exist tight correlations between neurodegenerative diseases' incidence and progression and aberrant protein aggregreferates in nervous tissue. However, the pathology of these diseases is not well known, leading to an inability to find an appropriate therapeutic approach to delay occurrence or slow many neurodegenerative diseases' development. The accessibility of induced pluripotent stem cells (iPSCs) in mimicking the phenotypes of various late‐onset neurodegenerative diseases presents a novel strategy for in vitro disease modeling. The iPSCs provide a valuable and well‐identified resource to clarify neurodegenerative disease mechanisms, as well as prepare a promising human stem cell platform for drug screening. Undoubtedly, neurodegenerative disease modeling using iPSCs has established innovative opportunities for both mechanistic types of research and recognition of novel disease treatments. Most important, the iPSCs have been considered as a novel autologous cell origin for cell‐based therapy of neurodegenerative diseases following differentiation to varied types of neural lineage cells (e.g. GABAergic neurons, dopamine neurons, cortical neurons, and motor neurons). In this review, we summarize iPSC‐based disease modeling in neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, and Huntington's disease. Moreover, we discuss the efficacy of cell‐replacement therapies for neurodegenerative disease.

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Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

Yousefi

Abdollahii

Kouhbanani

et al. 2020

Journal Cellular Physiology

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Glial cells in Parkinson´s disease: protective or deleterious?

Domingues

Pereira

Vilaça-Faria

et al. 2020

Cell. Mol. Life Sci.

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Parkinson's Disease Involving Glial Cell Dysfunction

Oukhrib,

Tamegart,

El Ghachi

et al. 2023

Physiology and Function of Glial Cells in Health and Disease

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It is well known that the decline in the viability of dopamine neurons slowly leads to the appearance of various symptoms characteristic of Parkinson's disease (PD). These symptoms depend mainly on dysfunction of nigrostriatal dopaminergic denervation. The cause of neuronal death has not yet been elucidated, although there are several hypotheses suggesting different factors that may trigger it. One possible mechanism of neurodegeneration is the establishment of chronic inflammation in the central nervous system, where glial cells are key regulators of inflammatory responses. They also play a phagocytic role, engulfing synapses, apoptotic cells, cellular debris and released toxic proteins. An imbalance in the activation of these cells can lead to an overproduction of cytotoxic factors, which contribute to the death of dopamine neurons. As PD involves not only the loss of dopamine neurons, but also the dysfunction of glial cells, whose loss or excessive activation can contribute to neuronal death, there is a need to better understand the role of these cells in PD in order to develop effective therapies.

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Generation of a human induced pluripotent stem cell line (CSC-42) from a patient with sporadic form of Parkinson's disease

Cited by 3 publications

References 2 publications

Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

Induced pluripotent stem cells (iPSCs) as game‐changing tools in the treatment of neurodegenerative disease: Mirage or reality?

Glial cells in Parkinson´s disease: protective or deleterious?

Parkinson's Disease Involving Glial Cell Dysfunction

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