Realizing highly chemoselective detection of H2S in vitro and in vivo with fluorescent probes inside core-shell silica nanoparticles

H2S-activatable near-infrared afterglow luminescent probes for sensitive molecular imaging in vivo

“…H 2 S is recognized as the third signaling gasotransmitter, participating in many essential physiological and pathological processes [36][37][38][39] . Throughout the past few years, many colorimetric and fluorescent probes have been developed for H 2 S measurement [52][53][54][55][56][57] . However, due to the low concentration and transient nature of H 2 S in biology 58 , the detection of endogenous H 2 S with these probes has been compromised by insufficient sensitivity, selectivity, or reaction kinetics.…”

Fluorescent probes based on nucleophilic aromatic substitution reactions for reactive sulfur and selenium species: Recent progress, applications, and design strategies

“…However, when the phenyl-S bond is strong, it is not only not less likely to react with RSS, but also less likely to be oxidized by ROS. Fortunately, because the valence state of S increases after oxidation, it is easily reduced by S with a lower valence state, so it readily reacts with RSS with lower p K a values [178] , [179] .…”

“…Zhao et al have studied thiol probes for a long time, and recently functionalized the BODIPY fluorophore with sulfoxide ( Fig. 14 , panel 43 ) [179] . Their probe was encapsulated in core–shell silica nanoparticles to improve chemical selectivity.…”

Recent progress in H2S activated diagnosis and treatment agents

“…61 H 2 Sactivated uorescent probes are mainly based on the difference of emission wavelength before and aer response. 62 Although a lot of effort has been expended, uorescence imaging is limited by problems such as the low concentration of endogenous H 2 S and the presence of a large number of interfering molecules, including reduced glutathione, cysteine (Cys) and thiol-containing proteins, in complex living systems. Therefore, it is still a signicant challenge to develop highly sensitive and selective uorescent probes.…”