Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances affects leukocyte telomere length in female newborns

Liu, Han; Chen, Qian; Lei, Lei; Zhou, Wei; Huang, Lisu; Zhang, Jun; Chen, Dan

doi:10.1016/j.envpol.2017.12.095

Cited by 40 publications

(21 citation statements)

References 35 publications

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“…Maternal smoking during pregnancy is the most prevalent preventable cause of low birthweight, neonatal morbidity and premature delivery 12 . It has been well established that maternal smoking is a significant risk factor for attention deficit hyperactivity disorder (ADHD), which has an almost 50% overlap with DCD 13 , but the association of maternal smoking during pregnancy and DCD among children is equivocal 14,15 . A study with 122 children from Canada indicated that children exposed to secondhand smoke in utero have 3 times increased risk of DCD 16 , while another study with 744 children in Auckland, New Zealand, demonstrated that children whose mothers smoke during pregnancy have an increased risk of DCD in comparison with children whose mothers are non-smokers 17 .…”

Section: Introductionmentioning

confidence: 99%

Mothers’ prenatal tobacco smoke exposure is positively associated with the occurrence of developmental coordination disorder among children aged 3–6 years: A cross-sectional study in a rural area of Shanghai, China

Yang¹,

Pan²,

Shen³

et al. 2020

Tob. Induc. Dis.

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INTRODUCTION Prenatal tobacco smoke exposure is a potential risk factor for developmental coordination disorder (DCD) in children, but evidence on the relationship between DCD in children and tobacco smoke exposure in women is limited in China. We conducted a cross-sectional study to understand the prevalence of prenatal tobacco smoke exposure among mothers and the prevalence of DCD among children and to explore if mothers' prenatal tobacco smoke exposure is positively associated with the occurrence of DCD among children. METHODS During 2018, we sampled 8586 children aged 3-6 years and their mothers in Songjiang district, Shanghai. DCD in children was identified by MABC-2 screening combined with pediatrician confirmation. Prenatal tobacco smoke exposure among mothers was classified into firsthand smoke (FHS) and secondhand smoke (SHS) exposure. SAS 9.2 software was applied to calculate the prevalence of DCD in children, the prevalence of prenatal FHS and SHS exposure in mothers and to analyze the differences by chi-squared test and logistic regression. RESULTS Among the 8586 women, the prevalence of prenatal FHS and SHS exposure was 0.94% and 20.79%, respectively. The prevalence of DCD in children was 6.65%, which was significantly higher in boys (7.64%) than in girls (5.51%), and children aged 3 years (9.77%) had a higher prevalence of DCD than children aged 4, 5 or 6 years (7.44%, 5.27% and 4.28%, respectively). In comparison with children whose mother was not exposed to prenatal FHS or SHS, the odds of having DCD was higher in children whose mother was exposed to prenatal FHS (OR=4.42; 95% CI: 2.62-7.44) and SHS (OR=1.77; 95% CI: 1.47-2.14), even after adjustment for potential confounders. CONCLUSIONS The occurrence of DCD among children is positively associated with prenatal tobacco smoke exposure among the mothers. It is crucial to implement tobacco control measures to decrease the prevalence of smoking among pregnant women and SHS exposure at home as well as in the work environment.

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Section: Introductionmentioning

confidence: 99%

Mothers’ prenatal tobacco smoke exposure is positively associated with the occurrence of developmental coordination disorder among children aged 3–6 years: A cross-sectional study in a rural area of Shanghai, China

Yang¹,

Pan²,

Shen³

et al. 2020

Tob. Induc. Dis.

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“…To date, only a few studies have examined the influence of PFAS on endpoints related to DNA stability and immortalization. Leukocyte telomere length was inversely associated with elevated PFOS and PFDA levels in female but not male newborns [197] and with serum PFOA levels in adults 50-65 years old [198]. In the same adult study, serum PFOS and PFHxS levels were positively and negatively associated with mitochondrial DNA content respectively [198].…”

Section: Causes Immortalizationmentioning

confidence: 79%

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

Temkin

Hocevar

Andrews

et al. 2020

IJERPH

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Per- and polyfluoroalkyl substances (PFAS) constitute a large class of environmentally persistent chemicals used in industrial and consumer products. Human exposure to PFAS is extensive, and PFAS contamination has been reported in drinking water and food supplies as well as in the serum of nearly all people. The most well-studied member of the PFAS class, perfluorooctanoic acid (PFOA), induces tumors in animal bioassays and has been associated with elevated risk of cancer in human populations. GenX, one of the PFOA replacement chemicals, induces tumors in animal bioassays as well. Using the Key Characteristics of Carcinogens framework for cancer hazard identification, we considered the existing epidemiological, toxicological and mechanistic data for 26 different PFAS. We found strong evidence that multiple PFAS induce oxidative stress, are immunosuppressive, and modulate receptor-mediated effects. We also found suggestive evidence indicating that some PFAS can induce epigenetic alterations and influence cell proliferation. Experimental data indicate that PFAS are not genotoxic and generally do not undergo metabolic activation. Data are currently insufficient to assess whether any PFAS promote chronic inflammation, cellular immortalization or alter DNA repair. While more research is needed to address data gaps, evidence exists that several PFAS exhibit one or more of the key characteristics of carcinogens.

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“…Intracellular ROS level is elevated by many xenobiotic substances, underlying the mechanism of caused cellular toxicity, including some PFASs . However, 6:2 FTOH and 8:2 FTOH did not cause oxidative DNA damage in rat testicular cells .…”

Section: Discussionmentioning

confidence: 94%

8:2 Fluorotelomer alcohol causes G1 cell cycle arrest and blocks granulocytic differentiation in HL‐60 cells

Wang

Zhou

et al. 2019

Environmental Toxicology

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Fluorotelomer alcohols (FTOHs) are fluorinated intermediates used in manufacturing specialty polymer and surfactants, with 8:2 FTOH the homologue of largest production. FTOHs were found to pose acute toxicity, hepatotoxicity, nephrotoxicity, developmental toxicity and endocrine-disrupting risks, whereas research regarding immunotoxicity and its underlying mechanism, especially on specific immune cells is limited. Here, we investigated the immunotoxicity of 8:2 FTOH on immature immune cells in an in vitro system. We observed that exposure of HL-60 cells, a human promyelocytic leukemic cell line, to 8:2 FTOH reduced cell viability in a dose-and time-dependent manner. In addition, 8:2 FTOH exposure caused G1 cell cycle arrest in HL-60 cells, while it showed no effect on apoptosis. Exposure to 8:2 FTOH inhibited the mRNA expression of cell cycle-related genes, including CCNA1, CCNA2, CCND1, and CCNE2. Moreover, exposure to 8:2 FTOH inhibited the mRNA expression of granulocytic differentiation-related genes of CD11b, CSF3R, PU.1, and C/EPBε in HL-60 cells . Furthermore, 8:2 FTOH exhibited no effect on intracellular ROS level, while hydralazine hydrochloride (Hyd), one reactive carbonyl species (RCS) scavenger, partially blocked 8:2 FTOH-caused cytotoxicity in HL-60 cells. Overall, the results obtained in the study show that 8:2 FTOH poses immunotoxicity in immature immune cells and RCS may partially underline its mechanism. K E Y W O R D S 8:2 FTOH, cell cycle arrest, differentiation block, immature immune cells, immunotoxicity, reactive carbonyl species

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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances affects leukocyte telomere length in female newborns

Cited by 40 publications

References 35 publications

Mothers’ prenatal tobacco smoke exposure is positively associated with the occurrence of developmental coordination disorder among children aged 3–6 years: A cross-sectional study in a rural area of Shanghai, China

Mothers’ prenatal tobacco smoke exposure is positively associated with the occurrence of developmental coordination disorder among children aged 3–6 years: A cross-sectional study in a rural area of Shanghai, China

Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances

8:2 Fluorotelomer alcohol causes G1 cell cycle arrest and blocks granulocytic differentiation in HL‐60 cells

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