Long-term neurodevelopmental outcome following low grade intraventricular hemorrhage in premature infants

Short-term feeding outcomes after neonatal brain injury

“…It is interesting to note the trend towards higher risk of feeding disorders in infants with milder forms of brain injury. This is in keeping with an increasing body of literature suggesting that milder forms of intraventricular haemorrhage and hypoxic ischaemic encephalopathy may not be as benign as previously thought, with studies demonstrating increased rates of cerebral palsy, neurosensory impairment, neuromotor impairment, cognitive impairment, behavioural difficulties, and other neurodevelopmental disabilities in these groups (Bolisetty et al, 2014;Finder et al, 2020;Hayes et al, 2018;Hollebrandse et al, 2020;Mukerji et al, 2015;Pfahl et al, 2018;Reiss et al, 2019). Potential mechanisms for the influence of lower grade IVH on neurodevelopmental outcomes include their negative impact on neural migration, injuries to the caudate nucleus and the destruction of cells destined for the subcortical structures, white matter injury and hypomyelination, and impaired cerebellar development (Bolisetty et al, 2014;Briana & Malamitsi-Puchner, 2019;Jeong et al, 2016;Volpe, 2019).…”

Decreased Incidence of Intraventricular Hemorrhage in Extremely Low Birth Weight Infants Using Customized Circulatory Management to Evaluate the Hemodynamic Change of Patent Ductus Arteriosus

“…A previous study reported grade II IVH in pre-term infants still leads to post-hemorrhagic hydrocephalus ( 39 ). The low-grade IVH may also affect brain tissue structure and long-term neurodevelopmental outcomes ( 40 – 42 ). It is for this reason we recognized IVH greater than grade II as one of primary outcomes in our study.…”