“…The presentation of solitary plasmacytoma depends on the involved organ, and as extramedullary plasmacytoma doesn’t involve bone or bone marrow, the typical findings of multiple myeloma including anemia, hypercalcemia, bone pain, and renal insufficiency are typically absent, which makes the diagnosis more challenging [ 5 ]. The reported cases in the literature were for symptomatic patients who presented with abdominal pain, vomiting, and upper GI bleeding with imaging and endoscopic findings of duodenal mass [ 6 , 7 ]. To our knowledge, only two cases of plasmacytoma presented with a duodenal ulcer were reported in the literature [ 8 , 9 ], which implies the extremely rare presentation of our patient.…”