293 Different impacts of saturated and unsaturated free fatty acids on lipid synthesis and inflammatory response in sebocytes in culture

Flori, Enrica; Mastrofrancesco, Arianna; Ottaviani, Monica; Ludovici, Matteo; Zouboulis, C. C.; Picardo, Mauro; Camera, Emanuela

doi:10.1016/j.jid.2016.06.313

Cited by 1 publication

(8 citation statements)

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“…In addition, Flori et al. reported that exogenous FFA were incorporated into neutral lipids in SZ95 sebocytes . Similarly, in the present study, the increase in cytoplasmic lipids after PA treatment indicates that sebocytes took up exogenous FFAs.…”

Section: Resultssupporting

confidence: 81%

“…In conclusion, there are some studies regarding lipogenic activity of FFA, and there are few studies about the specific role of PA, a major saturated form of FFA, on lipogenesis in sebocyte . However, it is still not reported the involvement of TLR in the production of inflammatory cytokines, IL‐6 and IL‐8 by PA.…”

Section: Resultsmentioning

confidence: 89%

“…Similarly, in the present study, the increase in cytoplasmic lipids after PA treatment indicates that sebocytes took up exogenous FFAs. Based on the previous studies, we suggested that the exogenous FFA can change the sebaceous lipogenesis; however, further studies are needed to investigate whether sebocytes used exogenous FFA to synthesize sebaceous lipid and exogenous FFAs changed the lipogenic activity of sebocytes.…”

Section: Resultsmentioning

confidence: 96%

“…We used PA as the major constituent of saturated fatty acid. However, there are various kinds of saturated and unsaturated FFA and the effect of these FFAs on lipid synthesis and inflammatory response on sebocyte were reported to be different . In addition, sebocyte cell line, SZ95 were only used in this study to investigate the effect of PA on lipogenesis and inflammatory cytokine production, because SZ95 is a well‐established immortalized human sebaceous gland cell line showing the characteristics of normal human sebocytes .…”

Section: Resultsmentioning

confidence: 99%

“…Considering that FFAs are also a major component of sebum, it is likely that changes in FFA concentration can affect both the synthesis of sebum as well as the inflammatory response in sebaceous glands . To date, few studies have reported about the effects of FFAs on sebocytes and the role of FFAs in the production of proinflammatory cytokines by sebocytes . In this study, we examined the role of PA in the development and aggravation of acne by evaluating PA effects on the lipogenesis and inflammation in SZ95 sebocytes.…”

Section: Introductionmentioning

confidence: 99%

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Enhancement of lipid content and inflammatory cytokine secretion in SZ95 sebocytes by palmitic acid suggests a potential link between free fatty acids and acne aggravation

Choi

Kim

et al. 2019

Experimental Dermatology

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A relationship between acne and free fatty acids (FFAs) has been suggested recently. However, the effects of FFAs on sebaceous glands are still largely unknown. At the same time, the role of FFAs during chronic inflammation is well established. Considering that FFAs are also a major component of sebum, it is likely that changes in FFA affect both the synthesis of sebum and the inflammatory response in sebaceous glands. In this study, we examined a hypothesis that FFAs increase the production of sebum and induce inflammation in the sebaceous glands. We found that treatment of SZ95 sebocytes with exogenously applied palmitic acid (PA), a major saturated FFA, induced a significant increase in intracellular lipid levels. Moreover, PA treatment also increased the expression and secretion of the proinflammatory cytokines in SZ95 sebocytes. We also found that Toll‐like receptors were required for the inflammatory response triggered by PA. The results of our study strengthen the notion about the link between acne and FFAs and suggest the mechanism underlying this relationship. Our results serve as a foundation for future work that will explore the association between FFA and acne and pave way to the development of novel treatment options for acne.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 96%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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